Objective To summarize the medication rule of traditional Chinese medicine（TCM） in treating coronary heart disease（CHD） with depression. Methods Clinical research literatures on CHD with depression from January 1

1999 to January 1

2019 were searched in Chinese National Knowledge Infrastructure（CNKI）

Wanfang Database

China Journal Fulltext Database（CJFD）

China Biology Medicine（CBM）. The prescriptions and drug information included in the literature were used to establish a database. The drug frequency and drug efficacy classification was counted. The commonly used drugs were analyzed

and the complex network analysis was performed. Results A total of 43 prescriptions were obtained and 102 Chinese herbal medicines were obtained

with a total frequency of 482

involving 19 kinds of drugs for tonifying deficiency

regulating qi

tranquilizing mind and eliminating phlegm

etc. The top 10 most frequently used Chinese medicines were Gancao（Radix Glycyrrhizae

29）

Chaihu（Radix Bupleuri

28）

Fuling（Poria

23）

Danshen（Radix Salviae Miltiorrhizae

20）

Chuanxiong（Rhizoma Ligustici Chuanxiong

10）

Yujin（Radix Curcumae

17）

Baishao（Radix Paeoniae Alba

17）

Zhiqiao（Fructus Aurantii

16）

Danggui（Radix Angelicae Sinensis

15）

Suanzaoren（Semen Ziziphi Spinosae

14）. Complex network analysis showed that the common drug pairs were Radix Bupleuri with Radix Glycyrrhizae（19）

Radix Bupleuri with Rhizoma Ligustici Chuanxiong（16）

Radix Bupleuri with Radix Curcumae（15）

Poria with Radix Glycyrrhizae（15）

Radix Bupleuri with Radix Paeoniae Alba（15）. The core prescriptions included Radix Bupleuri

Radix Paeoniae Alba

Fructus Aurantii

Radix Glycyrrhizae

Radix Angelicae Sinensis

Radix Curcumae

Ligustici Chuanxiong and Poria. Conclusion TCM treatment of CHD complicated with depression mainly relies on dispersing stagnated liver qi for relieving qi stagnation

promoting qi for activating blood circulation

and often uses Radix Bupleuri

Radix Paeoniae Alba

Fructus Aurantii

Radix Glycyrrhizae

Radix Angelicae Sinensis

Radix Curcumae

Ligustici Chuanxiong and other drugs. And herbs of invigorating spleen and replenishing qi

or tonifying and replenishing liver and kidney

or nourishing heart tranquillization were often used.