By combing relevant study results on syndrome essential elements and syndrome elements

it is proposed that substantial research should be conducted from the generating process of a syndrome rather than its existing outcome. By analyzing treatment aiming at its root causes

discussion on syndrome aiming at its root causes and the generating origin of syndrome

a system of three-basis syndrome differentiation is proposed and demonstrated in detail

which meets the needs of big data era and is suitable for intelligent diagnosis. It contains three aspects: basic material of syndrome

basic space of syndrome and basic movement of syndrome. Among them

basic material of syndrome is divided into 3 categories: physiological material

tangible pathological material and intangible pathogenic qi; basic space of syndrome is divided into 4 categories: five zang-viscera

six fu-viscera

extraordinary fu-viscera and body tissue; basic movement of syndrome is divided into 5 categories: deficiency

excess

too fast

too slow and reversion. The system of three-basis syndrome differentiation is different from syndrome elements and syndrome essential elements. It has advantages of realization on data sharing and performing normalized three-dimensional decomposition for syndromes through objectively expressing standard and decomposing independent modeling. It can provide reference for study on syndrome standardization and construction of traditional Chinese medicine intelligent auxiliary diagnosis and treatment system.