Objective To explore the characteristics of regional homogeneity（ReHo） of resting state brain function in patients with amnestic mild cognitive impairment（aMCI） and liver qi stagnation. Methods Questionnaires were used to screen normal subjects（normal group） aged from 46 to 65 years in communities in Zhengzhou City and patients with amnestic mild cognitive dysfunction and liver qi stagnation（liver qi stagnation aMCI group）. According to the same sex

same age（±2.5 years old）

and the same education level

1 ∶1 matching was applied to the 2 groups. Brain ReHo was analyzed by using resting state functional magnetic resonance imaging technique. Results Compared with the normal group

the ReHo values of the left inferior frontal gyrus

the left frontal gyrus and the left central anterior gyrus of the liver qi stagnation aMCI group were lower（t>0

P<0.001）

and the ReHo value in the left occipital gyrus of the liver qi stagnation aMCI group was increased（P<0.001）. Conclusion The ReHo values of the left inferior frontal gyrus

the left frontal gyrus

the central anterior gyrus and left occipital gyrus were changed in aMCI patients with liver qi stagnation.