Study on the Action Mechanisms of Traditional Chinese Medicine for the Intervention of Coronavirus Disease 2019 （COVID-19）: Based on the Literature

ZHANG Yan; TANG Dezhi; SHU Bing; LI Wenxiong; ZHANG Jiali; LI Yue; DING Fan; FENG Rui; HEMING Chao; CHEN Nan; SHI Qi; WANG Yongjun

doi:10.13288/j.11-2166/r.2020.13.002

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Study on the Action Mechanisms of Traditional Chinese Medicine for the Intervention of Coronavirus Disease 2019 （COVID-19）: Based on the Literature

更新时间：2021-11-10

- Study on the Action Mechanisms of Traditional Chinese Medicine for the Intervention of Coronavirus Disease 2019 （COVID-19）: Based on the Literature
- Journal of Traditional Chinese Medicine Vol. 61, Issue 13, Pages: 1110-1117(2020)
- 作者机构：
  
  上海中医药大学附属龙华医院/上海中医药大学脊柱病研究所
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2020.13.002
  CLC： R259
- Published：2020
- 稿件说明：
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[1]张岩,唐德志,舒冰,李文雄,张佳莉,李钺,丁凡,冯睿,赫明超,陈楠,施杞,王拥军.基于文献探讨中药干预新型冠状病毒肺炎的作用机制[J].中医杂志,2020,61(13):1110-1117.

ZHANG Yan, TANG Dezhi, SHU Bing, et al. Study on the Action Mechanisms of Traditional Chinese Medicine for the Intervention of Coronavirus Disease 2019 （COVID-19）: Based on the Literature[J]. Journal of Traditional Chinese Medicine2020, 61(13): 1110-1117.
[1]张岩,唐德志,舒冰,李文雄,张佳莉,李钺,丁凡,冯睿,赫明超,陈楠,施杞,王拥军.基于文献探讨中药干预新型冠状病毒肺炎的作用机制[J].中医杂志,2020,61(13):1110-1117. DOI： 10.13288/j.11-2166/r.2020.13.002.

ZHANG Yan, TANG Dezhi, SHU Bing, et al. Study on the Action Mechanisms of Traditional Chinese Medicine for the Intervention of Coronavirus Disease 2019 （COVID-19）: Based on the Literature[J]. Journal of Traditional Chinese Medicine2020, 61(13): 1110-1117. DOI： 10.13288/j.11-2166/r.2020.13.002.

摘要

国家卫生健康委员会和国家中医药管理局推荐中西医结合治疗新型冠状病毒肺炎。目前临床防治新型冠状病毒肺炎的中药及复方复杂多样

且对中药干预的疗效机制不甚清楚。通过分析应用于新型冠状病毒肺炎各期治疗的方药的文献

发现其可能机制是通过降低机体炎症因子表达、抑制细胞因子风暴、减少氧化应激-自由基堆积和细胞凋亡、改善机体免疫功能

从而发挥防治新型冠状病毒肺炎的作用。通过阐述中药干预新型冠状病毒肺炎的潜在机制

以期为后续临床治疗和药物研发提供参考。

Abstract

National Health Commission and National Administration of Traditional Chinese Medicine recommend integrated Chinese and western medicine for the treatment of coronavirus disease 2019（COVID-19）. At present

the traditional Chinese medicine（TCM） and its compounds for the clinical prevention and treatment of COVID-19 are complex and diverse

and the therapeutic mechanisms of TCM intervention are not clear. Through the analysis of the formulations applied in the treatment of COVID-19 in different stages

it is found that the possible mechanisms are to reduce the expression of inflammatory factors

inhibit cytokine storms

reduce the accumulation of oxidative stress free radicals and cell apoptosis

and improve the immune functions of the body

so that TCM play a role in the prevention and treatment of COVID-19. The potential mechanisms of TCM intervention in COVID-19 are discussed in order to provide references for subsequent clinical treatment and drug development.

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Related Institution

Dongzhimen Hospital，Beijing University of Chinese Medicine

School of Life Sciences， Beijing University of Chinese Medicine

School of Traditional Chinese Medicine，Beijing University of Chinese Medicine

Ministry of Education Hold Key Laboratory of Health Preservation of Chinese Medicine， Beijing University of Chinese Medicine

Science and Technology Office of Beijing University of Chinese Medicine/Ministry of Education Higher Education Institution Discipline Innovation and Talent Introduction Base， Beijing University of Chinese Medicine

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