To treat of severe coronavirus disease 2019（COVID-19） is crucial

patient of severe type will easily develop into critical type or even eventually death without timely and effective treatment. Traditional Chinese medicine（TCM） pathogenesis of severe COVID-19 is complex

involving many factors such as toxin

dampness

cold

heat

dryness

stasis and deficiency. Based on the disease development rule analyzed and clinical experience we summarized

we adopt removing toxicity

clearing dampness

clearing heat and preventing asthma as the core therapies

with Huashi Baidu Fomula（化湿败毒方） as the basic prescription

with treatment based on syndrome differentiation according to different conditions. Meanwhile

TCM injections were combined to exert TCM characteristics of strengthening the body resistance to eliminate evil factors and multiple target effects

effectively alleviate the patients′ clinical conditions

and finally achieve the goal of cure.