Coronavirus disease（COVID-19） belongs to the category of "epidemic disease" in traditional Chinese medicine（TCM）. National Health Commission and National Administration of Traditional Chinese Medicine recommend that Qingfei Paidu Decoction（清肺排毒汤） could be used in the treatment of COVID-19 by integrated Chinese and western medicine. Qingfei Paidu Decoction comes from the optimized combination of Maxing Shigan Decoction（麻杏石甘汤）

Shegan Mahuang Decoction（射干麻黄汤）

Xiao Chaihu Decoction（小柴胡汤）

and Wuling Powder（五苓散） in Treatise on Cold Pathogenic and Miscellaneous Diseases（《伤寒杂病论》）. It has the effects of dispelling cold and dampness

clearing heat and turbidity

and ventilating lungs for invigorating spleen. Modern pharmacological studies have shown that the 4 main prescriptions of Qingfei Paidu Decoction have the anti-inflammatory and anti-viral effects. From the perspective of traditional Chinese medicine theory and modern pharmacology

the theoretical basis of Qingfei Paidu Decoction in the treatment of COVID-19 was studied.