Research Ideas of Traditional Chinese Medicine in Improving Revascularization of Hepatitis B Cirrhosis

ZHAO Zhimin; LI Zhengxin; ZHU Tingting; LIU Chenghai

doi:10.13288/j.11-2166/r.2020.15.008

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Research Ideas of Traditional Chinese Medicine in Improving Revascularization of Hepatitis B Cirrhosis

更新时间：2021-11-10

- Research Ideas of Traditional Chinese Medicine in Improving Revascularization of Hepatitis B Cirrhosis
- Journal of Traditional Chinese Medicine Vol. 61, Issue 15, Pages: 1318-1321(2020)
- 作者机构：
  
  1. 上海中医药大学附属曙光医院
  2. 上海市中医临床重点实验室
  3. 上海中医健康服务协同创新中心
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2020.15.008
  CLC： R259
- Published：2020
- 稿件说明：
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[1]赵志敏,李正鑫,朱亭亭,刘成海.中医药改善乙型肝炎肝硬化血管重塑研究思路[J].中医杂志,2020,61(15):1318-1321.

ZHAO Zhimin, LI Zhengxin, ZHU Tingting, et al. Research Ideas of Traditional Chinese Medicine in Improving Revascularization of Hepatitis B Cirrhosis[J]. Journal of Traditional Chinese Medicine2020, 61(15): 1318-1321.
[1]赵志敏,李正鑫,朱亭亭,刘成海.中医药改善乙型肝炎肝硬化血管重塑研究思路[J].中医杂志,2020,61(15):1318-1321. DOI： 10.13288/j.11-2166/r.2020.15.008.

ZHAO Zhimin, LI Zhengxin, ZHU Tingting, et al. Research Ideas of Traditional Chinese Medicine in Improving Revascularization of Hepatitis B Cirrhosis[J]. Journal of Traditional Chinese Medicine2020, 61(15): 1318-1321. DOI： 10.13288/j.11-2166/r.2020.15.008.

摘要

乙型肝炎肝硬化发展过程中肝脏血管稳态失衡、血管重塑是影响疾病进展和逆转的重要病理改变

且血管重塑分子机制复杂。乙型肝炎肝硬化是中医药治疗优势病种

中药具有多层次、多靶点综合治疗的特点适合血管重塑的整体调节。因此

需利用多学科交叉及系统生物学的方法和策略来探讨中医药改善乙型肝炎肝硬化血管重塑的可能作用机制

从而发现药物治疗的关键靶点。

Abstract

In the development of hepatitis B cirrhosis

unbalanced liver blood vessel and vascular remodeling are important pathological changes that affect disease progression and reversal

and the molecular mechanism of hepatitis B cirrhosis vascular remodeling is complex. Traditional Chinese Medicine（TCM） has dominant position in treatment of hepatitis B cirrhosis

TCM has the characteristics of multi-level and multi-target comprehensive treatment

and is suitable for the overall regulation of vascular remodeling. Therefore

it is necessary to use multidisciplinary cross-cutting and systems biology methods and strategies to explore the possible mechanism of action of TCM to improve the vascular remodeling of hepatitis B cirrhosis

so as to discover the key targets of the therapy.

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