Objective To observe the clinical efficacy of Liangxue Tongyu Formula（凉血通瘀方） in treating cerebral hemorrhage patients with excess syndrome

and to explore the possible mechanism. Methods A total of 85 patients were randomly divided into 42 cases in the control group and 43 cases in the treatment group. The control group was treated with internal medicine of western medicine. The treatment group received oral or nasal feeding Liangxue Tongyu Formula on the basis of the control group

1 dose per day

all courses for 14 days. The stroke diagnosis score

the National Institutes of Health Stroke Scale（NIHSS） score

serum brain-derived neurotrophic factor（BDNF）

nerve growth factor（NGF）

superoxide dismutase（SOD） and malondialdehyde（MDA） were observed in both groups before treatment and after 7 and 14 days of treatment. Clinical efficacy was evaluated after treatment. Results The total effective rate of clinical efficacy of the treatment group was 93.0%

which was higher than that in the control group

83.3%（P<0.05）. Compared with those before treatment in this group

after 7 and 14 days of treatment

stroke diagnostic score and NIHSS score decreased

serum BDNF and SOD levels increased

and MDA levels decreased（P<0.05 or P<0.01） in the treatment group; Compared with the same time of the control group

the stroke diagnosis score and NIHSS score decreased

serum BDNF

NGF

and SOD levels increased

and MDA levels decreased after 14 days of treatment in the treatment group（P<0.01）. Conclusion Liangxue Tongyu Formula can improve the symptoms and signs

promote the recovery of nerve function and improve the clinical efficacy of cerebral hemorrhage patients with excess syndrome. Its mechanism may be related to the improvement of neurotrophic factors and the reduction of oxidative stress.