Objective To investigate the influence of Wenxin Grannle（稳心颗粒） on the expression of circulating microRNA-1（miR-1）

ventricular arrhythmia incidence

survival rate and heart function. Methods A total of 98 patients with STEMI were randomly into a treatment group and a control group

with 49 cases in each group. Both groups of patients were treated with conventional treatment including emergency percutaneous coronary intervention（PCI）. The treatment group was added with Wenxin Grannle

9 g each time

3 times a day. The course of treatment in both groups was 3 months. The circulating miR-1 expression before and after treatment between two groups of patients

as well as the incidence of ventricular arrhythmia

mortality

cardiac function indexes including left ventricular ejection fraction（LVEF）

end-diastolic left ventricular anteroposterior diameter（LVd） and end-systolic left ventricle front and back diameter（LVs） were compared. Results After treatment

the expression level of circulating miR-1 was significantly reduced（P<0.05） in both groups

and the expression level of circulating miR-1 in the treatment group was significantly lower than that of the control group（P<0.05）. After treatment

the LVEF of the both groups of patients was significantly increased

and the LVd and LVs were significantly decreased（P<0.05）

and patients in the treatment group improved more significantly than the control group（P<0.05）. The incidence of ventricular arrhythmia in the treatment group after treatment was 16.33%

and that in the control group was 24.49%. The treatment group was significantly lower than the control group（P<0.05）. The mortality rate of the treatment group during the 3-month follow-up was 10.2%

and that of the control group was 18.4%. There was no statistically significant difference between groups（P>0.05）. Conclusion After PCI

Wenxin Grannle combine with conventional treatment can further reduce circulating miR-1 expression in STEMI patients

improving cardiac function

reducing the incidence of ventricular arrhythmia.