Syndrome is one of the core contents of the theoretical system of traditional Chinese medicine（TCM）. Based on the objective evidence of modern TCM syndrome research and combined with TCM classic theories

the "three causes" theory of syndrome formation is proposed. That is

pathogenic factors

genetic constitution

and disease stage are the main factors that determine syndromes. From the "three causes" identification of syndromes

the preparation of animal models with the three-dimensional disease-syndrome combination

and the basic research of three-dimensional syndrome biology

the application results and prospects were explained.