Clinical Observation on Modified Guizhi Decoction （桂枝汤） for the Treatment of 30 Cases of Cold Type Urticaria with Syndrome of Superficies Tightened By Wind-cold

WU Min; GUO Jing; ZHANG Hongya; LIU Taofeng; LIU Xiaoping; SUN Hongbo; WANG Jianfeng; CAO Yu; ZHANG Wei

doi:10.13288/j.11-2166/r.2020.19.013

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Clinical Observation on Modified Guizhi Decoction （桂枝汤） for the Treatment of 30 Cases of Cold Type Urticaria with Syndrome of Superficies Tightened By Wind-cold

更新时间：2021-11-10

- Clinical Observation on Modified Guizhi Decoction （桂枝汤） for the Treatment of 30 Cases of Cold Type Urticaria with Syndrome of Superficies Tightened By Wind-cold
- Journal of Traditional Chinese Medicine Vol. 61, Issue 19, Pages: 1717-1720(2020)
- 作者机构：
  
  1. 安徽中医药大学第一附属医院
  2. 成都中医药大学附属医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2020.19.013
  CLC： R275.9
- Published：2020
- 稿件说明：
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[1]吴敏,郭静,张虹亚,刘涛峰,刘小平,孙洪波,王建锋,曹宇,章纬.加味桂枝汤治疗寒冷型荨麻疹风寒束表证30例临床观察[J].中医杂志,2020,61(19):1717-1720.

WU Min, GUO Jing, ZHANG Hongya, et al. Clinical Observation on Modified Guizhi Decoction （桂枝汤） for the Treatment of 30 Cases of Cold Type Urticaria with Syndrome of Superficies Tightened By Wind-cold[J]. Journal of Traditional Chinese Medicine2020, 61(19): 1717-1720.
[1]吴敏,郭静,张虹亚,刘涛峰,刘小平,孙洪波,王建锋,曹宇,章纬.加味桂枝汤治疗寒冷型荨麻疹风寒束表证30例临床观察[J].中医杂志,2020,61(19):1717-1720. DOI： 10.13288/j.11-2166/r.2020.19.013.

WU Min, GUO Jing, ZHANG Hongya, et al. Clinical Observation on Modified Guizhi Decoction （桂枝汤） for the Treatment of 30 Cases of Cold Type Urticaria with Syndrome of Superficies Tightened By Wind-cold[J]. Journal of Traditional Chinese Medicine2020, 61(19): 1717-1720. DOI： 10.13288/j.11-2166/r.2020.19.013.

摘要

目的观察加味桂枝汤治疗寒冷型荨麻疹风寒束表证的临床疗效和安全性。方法 60例寒冷型荨麻疹风寒束表证患者随机分为治疗组和对照组各30例。治疗组采用加味桂枝汤治疗

每日1剂。对照组采用口服盐酸西替利嗪片治疗

每次10mg

每日1次。两组均治疗28天。分别于治疗前及治疗7、14、28天时对患者瘙痒程度、风团数目、风团直径、持续时间、发作频率进行评分

并判定临床疗效。结果治疗组及对照组治疗愈显率分别为96.67%和80.00%

两组比较差异无统计学意义（P>0.05）。与本组治疗前比较

两组瘙痒程度、风团数目、风团直径、持续时间在治疗7天、14天、28天时均降低（P<0.05）;发作频率治疗组在治疗7天、14天、28天时

对照组在治疗14天、28天时降低（P<0.05）。治疗14天时治疗组瘙痒程度、风团数目、发作持续时间、发作频率

对照组瘙痒程度、风团直径、持续时间、发作频率

比治疗7天时降低（P<0.05）;治疗28天时治疗组瘙痒、风团直径

对照组发作频率

比治疗14天时降低（P<0.05）。与对照组同时间比较

治疗组治疗7天时风团直径、持续时间、发作频率

14天时瘙痒程度、风团数目、发作频率

28天时瘙痒程度、风团数目、风团直径、持续时间、发作频率的差异均有统计学意义（P<0.05）。结论加味桂枝汤可安全有效治疗寒冷型荨麻疹风寒束表证

改善临床症状。

Abstract

Objective To observe the clinical effect and safety of modified Guizhi Decoction（桂枝汤） on cold type urticaria of superficies tightened by wind-cold. Methods A total of 60 cases of patients with cold type urticaria of superficies tightened by wind-cold were randomly divided into a treatment group and a control group

with 30 cases in each group. The treatment group received modified Guizhi Decoction for treatment

one dose per day

while the control group was orally given cetirizine hydrochloride tablets

10 mg each time

once a day. Both groups were treated for 28 days. Before treatment and on the 7 th

14 th

and 28 th day of treatment

patients were scored on the degree of itching

number of wheal

diameter of wheal

duration

and frequency of attacks

and the clinical efficacy was determined. Results The markedly effective rate was 96.67% in the treatment group and 80.00% in the control group

and the difference was not statistically significant（P>0.05）. Compared within group before treatment

the degree of pruritus

the number of wheal

the diameter of wheal

and the duration of both groups were reduced on the 7 th

14 th

and 28 th day of treatment（P<0.05）. Frequency of attacks was reduced on the 7 th

14 th and 28 th day in the treatment group and on the 14 th and 28 th day in the control group（P<0.05）. The degree of pruritus

the number of wheal

the duration of attacks

and the frequency of attacks in the treatment group on the 14 th day were lower than those on the 7 th day（P<0.05）; while the degree of pruritus

diameter of wheal

duration and frequency of attacks on the 14 th day were lower than those on the 7 th day（P<0.05）. On the 28 th day

degree of pruritus

diameter of wheal in the treatment group

frequency of attacks in the control group was lower than those on the 14 th day（P<0.05）. Compared with the control group at the same time

the differences were statistically significant in wheal diameter

duration

attack frequency on the 7 th day

degree of pruritus

the number of wheal

attack frequency on the 14 th day

and itching degree

the number of wheal

wheal diameter

duration

frequency of attack on the 28 th day（P<0.05）. Conclusion Modified Guizhi Decoction is safe and effective for cold type urticaria of tightened by wind-cold and can improve clinical symptoms.

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Related Institution

The First Affiliated Hospital of Guiyang College of Traditional Chinese Medicine

First Affiliated Hospital of Chengdu Medical College

School of Basic Medical Sciences,Guiyang College of Traditional Chinese Medicine

Affiliated Hospital of Chengdu University

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