Objective To observe the clinical efficacy of Fufang Huangbai Fluid（复方黄柏液） continuous infusion combined with vaccum sealing drainage（VSD） in the treatment of refractory poisonous snakebite ulcer. Method A total of 72 patients with refractory poisonous snakebite ulcer were randomly divided into a treatment group and a control group

with 36 cases in each group. Both groups were treated routinely after admission. After thorough debridement and decompression

VSD continuous negative pressure drainage was used. The treatment group was perfused and washed with Fufang Huangbai Fluid

and the control group was perfused and washed with the same volume of normal saline. VSD was removed after 6 days of treatment. Wound bacteriology and the expression amount of basic fibroblast growth factor（bFGF） and epidermal growth factor（EGF） in wound tissue were observed before and after treatment.Wound area and healing rate were calculated. Wound TCM syndrome scores were compared

and clinical efficacy was evaluated. Results After treatment

the number of patients infected with Gram-positive and Gram-negative bacteria decreased

and the infection rate of Gram-positive and Gram-negative bacteria was lower than that before treatment（P>0.05）; after treatment

the infection rate of Gram-positive bacteria and Gram-negative bacteria and the number of infected cases in the treatment group were significantly lower than those in the control group（P<0.05）; the expression of bFGF and FGF in both groups was significantly increased after treatment（P<0.05）); after treatment

the expression of bFGF and EGF in the treatment group was higher than that in the control group（P>0.05）. After treatment

the wound area of both groups was significantly reduced（P<0.01）

and the wound healing rate was significantly improved（P<0.01）. After treatment

the scores of TCM syndromes in both groups were significantly lower than those before treatment（P<0.05）

and the scores of TCM syndromes in the treatment group were significantly lower than those in the control group（P<0.01）. The total effective rate of the treatment group was 94.44%

and that of the control group was 86.11%. The difference was statistically significantly（P<0.05）. Conclusion Fufang Huangbai Fluid continuous infusion combined with VSD in the treatment of refractory snake-wound ulcer

can effectively reduce the swelling and pain of the bite ulcer

control the bacterial infection of the wound

and promote the expression of related growth factors

thereby promoting wound healing.