Action Mechanism of Dahuang （Rhubarb）-Huanglian （Coptis） Drug Pair in the Treatment of Hypertension: Based on Network Pharmacology

YANG Shuangjie; LIU Junjie; WU Yan; ZHANG Yili; LIU Qi; TAN Nannan; WANG Zhiyin; ZHAO Huihui; WANG Wei

doi:10.13288/j.11-2166/r.2020.20.016

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Action Mechanism of Dahuang （Rhubarb）-Huanglian （Coptis） Drug Pair in the Treatment of Hypertension: Based on Network Pharmacology

更新时间：2021-11-10

- Action Mechanism of Dahuang （Rhubarb）-Huanglian （Coptis） Drug Pair in the Treatment of Hypertension: Based on Network Pharmacology
- Journal of Traditional Chinese Medicine Vol. 61, Issue 20, Pages: 1827-1832(2020)
- 作者机构：
  
  北京中医药大学中医学院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2020.20.016
  CLC： R285
- Published：2020
- 稿件说明：
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[1]杨双杰,刘俊杰,吴晏,章轶立,刘齐,谭楠楠,王旨引,赵慧辉,王伟.基于网络药理学探讨大黄黄连药对治疗高血压病的作用机制[J].中医杂志,2020,61(20):1827-1832.

YANG Shuangjie, LIU Junjie, WU Yan, et al. Action Mechanism of Dahuang （Rhubarb）-Huanglian （Coptis） Drug Pair in the Treatment of Hypertension: Based on Network Pharmacology[J]. Journal of Traditional Chinese Medicine2020, 61(20): 1827-1832.
[1]杨双杰,刘俊杰,吴晏,章轶立,刘齐,谭楠楠,王旨引,赵慧辉,王伟.基于网络药理学探讨大黄黄连药对治疗高血压病的作用机制[J].中医杂志,2020,61(20):1827-1832. DOI： 10.13288/j.11-2166/r.2020.20.016.

YANG Shuangjie, LIU Junjie, WU Yan, et al. Action Mechanism of Dahuang （Rhubarb）-Huanglian （Coptis） Drug Pair in the Treatment of Hypertension: Based on Network Pharmacology[J]. Journal of Traditional Chinese Medicine2020, 61(20): 1827-1832. DOI： 10.13288/j.11-2166/r.2020.20.016.

摘要

目的基于网络药理学探讨大黄-黄连药对治疗高血压病的作用机制。方法利用TCMSP数据库

挖掘大黄、黄连的活性成分。利用UniProt数据库校正靶点的官方基因名称。通过OMIM、TTD、Pharmgkb及Disgenet-Gene数据库得到高血压病的相关靶点

并与大黄-黄连药对作用靶点取交集

得到其治疗高血压病的有效靶点。将上述靶点输入到String数据库进行蛋白质-蛋白质相互作用（PPI）网络预测

最后利用DAVID数据库进行GO和KEGG富集分析

揭示大黄-黄连药对治疗高血压病的潜在信号通路。结果共筛选出大黄-黄连药对21个药物活性成分以及67个治疗高血压病的靶点。通过PPI网络分析

大黄-黄连药对治疗高血压病可能与IL6、VEGFA、JUN、TNF、TP53、PTGS2、IL1β、EGF、EGFR、NOS3等蛋白有关。GO和KEGG分析结果显示

大黄-黄连药对治疗高血压病的靶点显著富集于HIF-1信号通路、TNF信号通路、钙信号通路、cGMP-PKG信号等通路。结论大黄-黄连药对治疗高血压病具有多靶点、多途径、多通路的特点

HIF-1信号通路、TNF信号通路、钙信号通路是其降压作用的主要通路。

Abstract

Objective To explore the mechanism of Dahuang（Rhubarb）-Huanglian（Coptis）

a drug pair in the treatment of hypertension based on network pharmacology. Methods TCMSP database was used to mine the active components of Radix et Rhizoma Rhei and Rhizoma Coptidis. UniProt database was used to correct the official gene name of the target. Through OMIM

TTD

Pharmgkb and Disgenet-Gene database

the relevant targets of hypertension were obtained. We took the intersection of rhubarb-Coptis

a drug pair on the target points

obtaining its effective target for the treatment of hypertension. The above targets were input into the String database for protein-protein interaction（PPI） network prediction

and finally the DAVID database was used for GO and KEGG enrichment analysis to reveal the potential signal pathways of rhubarb-Coptis

a drug pair for the treatment of hypertension. Results A total of 21 active ingredients of Rhubarb-Coptis

a drug pair and 67 targets for the treatment of hypertension were screened out. Through PPI network analysis

rhubarb-Coptis

a drug pair may be related to IL6

VEGFA

JUN

TNF

TP53

PTGS2

IL1β

EGF

EGFR

NOS3 and other proteins for the treatment of hypertension. GO and KEGG analysis results showed that the targets of rhubarb-Coptis

a drug pair for the treatment of hypertension were significantly enriched in HIF-1 signaling pathway

TNF signaling pathway

calcium signaling pathway

cGMP-PKG signaling and other pathways. Conclusion Rhubarb-Coptis

a drug pair has the characteristics of multiple targets

multiple pathways and multiple pathways for the treatment of hypertension. HIF-1 signaling pathway

TNF signaling pathway

and calcium signaling pathway are the main pathways for its antihypertensive effect.

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