Objective To observe the application efficacy of comprehensive Chinese medicine（TCM） therapy in post-traumatic stress disorder（PTSD） of breast cancer based on self-healing WeChat applet. Method A total of 120 breast cancer patients with PTSD were randomized into a test group and a control group

with 60 patients in each group. The control group was treated with Xihuang Jiedu Capsule（西黄解毒胶囊） 0.5 g orally once

3 times a day. On the basis of intervention control group

the test group added with comprehensive TCM interventions based on self-healing WeChat applet including TCM psychotherapy

five-tone therapy

relaxation training

diet adjustment

and magnetic ear acupunctur

and self-rehabilitation training 3 times a week. Both groups intervened for 12 weeks. The post-traumatic stress disorder self-rating scale（PCL-C）

quality of life scale（FACT-B）

Pittsburgh Sleep Quality Index（PSQI）

and Hamilton Depression Scale（HAMD） scores

patient′s sleep quality

bad mood and quality of life improvement were evaluated before and after intervention. Results Compared with those before intervention

PCL-C

FACT-B

PSQI

and HAMD scores of both groups of improved after intervention（P<0.05）; compared with the control group

PCL-C

PSQI

and HAMD scores of the test group after the intervention decreased

while the FACT-B score increased（P<0.05）. Conclusion Comprehensive TCM therapy combined with Xihuang Jiedu Capsules based on self-healing WeChat applet can help improving depression and other negative emotions of patients with breast cancer PSTD

and improving the quality of life.