Objective To explore the effects of acupuncture at acupoint "Jiangya Formula（降压方）" on myocardial hypertrophy in spontaneously hypertensive rats（SHR） and its possible mechanism. Method A total of 10 male WKY rats were selected as the blank group

and 30 SHR rats were randomly divided into a model group

a minimization acupuncture group and a Jiangya Formula group

with 10 rats in each group. Rats in the Jiangya Formula group were given acupuncture on both sides of "Renying（ST 9）"

"Quchi（LI11）" and "Zusanli（S36）" points

once a day

for 6 consecutive days

with 1 day rest; the minimization acupuncture group was only shallowly punctured each point

without manupulation

and rats in each group were intervened for 8 weeks. The systolic blood pressure of the tail artery was measured before the intervention and on the end of the 2 nd

4 th

6 th

and 8 th week; after the intervention

cardiac ultrasound was used to detect the diastolic thickness of the ventricular septum（IVSS）

the left ventricular end diastolic diameter（LVIDd）

diastolic thickness of the posterior wall of the left ventricle（LVPWd）

and to calculate the heart weight index（HWI）; the myocardial tissue structure of rats in each group was observed by WGA staining method

and the expression of atrial natriuretic peptide（ANP） mRNA and β-myosin heavy chain（β-MHC） mRNA in myocardial tissue were detected by RT-qPCR method. Results Before the intervention and at the end of the 2 th

4 th

6 th

8 th week intervention

the systolic blood pressure of the tail artery in the model group was significantly higher than that of the blank group（P<0.05）; at the 4 th

6 th

8 th week

the systolic blood pressure of rats in the Jiangya Formula group was significantly lower than that in the model group and the minimization acupuncture group（P<0.05）. Compared with the blank group

the expression of IVSS

LVPWd

HWI

myocardial tissue ANP and β-MHC mRNA in the model group increased

the diameter and cross-sectional area of myocardial cells increased

and the LVIDd decreased（P<0.05）; compared with the model group

the above-mentioned indexes of the rats in the Jiangya Formula group were improved（P<0.05）; while the indexes of the rats in the minimization acupuncture group were not significantly different from the model group（P>0.05）. Conclusion Acupuncture at acupoint "Jiangya Formula（降压方）" can effectively improve the blood pressure and myocardial hypertrophy state of SHR

which may be achieved by inhibiting the expression of ANP and β-MHC mRNA in myocardial tissue.