Objective To evaluate the effects of Tiaochang Xiaoliu Formula（调肠消瘤方） in the prevention of colorectal adenoma recurrence one year after colorectal polypectomy. Methods A total of 410 patients who underwent colorectal adenoma resection in the Endoscopy Center of the Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine were randomly divided into a treatment group and a control group with 205 patients in each group. Both groups of patients were given routine support therapy for 3-5 days after operation

and health education including reasonable diet such as increasing dietary fiber

reducing red meat intake

quitting smoking and alcohol

insisting on exercise

weight control

regular rest and mood adjustment. The treatment group was additionally treated with Tiaochang Xiaoliu Formula decoction

once a day

for 3 months. Patients in both groups were required to review for colonoscopy 1 year after colorectal adenoma resection. The adenomas recurrence rate

the number of recurrent adenomas

pathological condition and location

were compared between groups. The patient′s symptom score before and after treatment was recorded

the adverse reactions was observed

and the risk of recurrence factor was analyzed. Results A total of 359 patients completed the test including 176 in the treatment group and 183 in the control group.（1）One year after polypectomy

the recurrence rate of adenoma was 45.5%（80/176） in treatment group

lower than that in the control group（61.7%

113/183）

the difference was statistically significant（P<0.05）. The advanced adenoma rate in treatment group was 1.3%（1/80）

lower than that of the control group（5.3%

6/113）. The difference was not significant（P>0.05）. The number

location and pathology of recurrent adenomas in both groups had no significant difference（P>0.05）.（2）One year after operation

the symptom scores of both groups were lower than those before treatment（P<0.05）. The scores of the treatment group [（0.62±1.343） points] was lower than that of the control group [（1.22±2.062） points]（P<0.05）.（3）Multivariate Logistic regression analysis suggested the intervention of Tiaochang Xiaoliu Formula reduced the risk of adenoma recurrence（OR=0.517

95%CI: 0.326-0.821）. The number

location and pathology of adenoma were independent risk factors for adenoma recurrence.（4）During the treatment

no adverse reactions were found in treatment group. Conclusion Tiaochang Xiaoliu Formula shows certain effects in reducing the recurrence rate of colorectal adenoma of patients one year after colorectal polypectomy and improveing the syndrome of patients.