LI Shaohong, WANG Yuguang, HE Liyun, et al. Analysis of Registered Clinical Trials of Coronavirus Disease 2019: Existing Problems and Suggestions[J]. Journal of Traditional Chinese Medicine2020, 61(23): 2025-2030.
LI Shaohong, WANG Yuguang, HE Liyun, et al. Analysis of Registered Clinical Trials of Coronavirus Disease 2019: Existing Problems and Suggestions[J]. Journal of Traditional Chinese Medicine2020, 61(23): 2025-2030.DOI: 10.13288/j.11-2166/r.2020.23.001.
Analysis of Registered Clinical Trials of Coronavirus Disease 2019: Existing Problems and Suggestions
Objective To analyze the registered clinical trials of coronavirus disease 2019(COVID-19) in China and abroad and to summarize existing problems and make suggestions. Methods The COVID-19 clinical trials registered at the Chinese Clinical Trial Registry and clinical trial resitration in the United States(clinicaltrials.gov) from December 1 st 2019 to February 17 th
2020 were retrieved
and the key information was extracted and evaluated to analyze problems. Results A total of 164 registered studies were enrolled including 140 at Chinese clinical trial registration centers and 24 at clinicaltrials.gov. Hubei had the largest number of registrations(53)
followed by Zhejiang(21); 108(65.85%) interventional studies
46(28.05%) observational studies
10(6.10%) preventive and diagnostic studies; 117(71.34%) Western medicine related studies
35(21.34%) Chinese medicine related studies
12(7.32%) integrated traditional Chinese and Western medicine related studies. Among the intervention measures of TCM
the comprehensive treatment of traditional Chinese medicine(TCM)
integrated traditional Chinese and Western medicine treatment and the treatment based on syndrome differentiation were the main ones. The total sample size of the study was from 10 cases to 400 cases; 128 trials took mild and common types as the research objects. In interventional clinical studies
52 studies took time or rate of negative conversion of the virus as the outcome
followed by 41 studies on clinical recovery/clinical remission
32 studies on lung function
lung imaging indicators
and 23 studies on mortality rate and the critically ill or critically ill conversion rate. Conclusion The currently registered clinical studies on COVID-19 show diversified characteristics. It is recommended to further explore the advantages of TCM in treatment of severe and critical illness
pay attention to TCM treatment in the recovery period
and strengthen the epidemiological investigation and stuides on syndromes related to the etiology and pathogenesis of TCM.
Registration Status of Clinical Trials Exploring Acupuncture and Moxibustion for Treatment of Pain on the WHO International Clinical Trial Registry Platform
Clinical Diagnosis and Treatment Strategies for Severe Cases of Coronavirus Disease 2019
Characteristics of Traditional Chinese Medicine Syndromes in Mild COVID-19 Cases of Omicron Variant in Shanghai
The Value of “Epidemic Pathogen Tropism” in the Diagnosis and Treatment of Epidemic Diseases
Retrospective Analysis of Correlation between Traditional Chinese Medicine Treatment and Liver Injury in Coronavirus Disease 2019 (COVID-19)
Related Author
CUI Tangming
ZHANG Yiying
XU Ji
Fengwen YANG
Kai WANG
Ling LYU
Shujie ZAN
Wei ZHANG
Related Institution
Science and Technology Information Center, Shanghai University of Traditional Chinese Medicine
Tianjin University of Traditional Chinese Medicine
The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine
Shunyi Hospital, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine