Effects of Qiwei Baizhu Powder （七味白术散） on Glucose and Lipid Metabolism and Intestinal Flora in Obesity Patients of Spleen Deficiency and Dampness Disturbing Type

LIU Ling; LU Xiyuan; HE Ke; ZHU Lihua

doi:10.13288/j.11-2166/r.2020.23.013

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Effects of Qiwei Baizhu Powder （七味白术散） on Glucose and Lipid Metabolism and Intestinal Flora in Obesity Patients of Spleen Deficiency and Dampness Disturbing Type

更新时间：2021-11-10

- Effects of Qiwei Baizhu Powder （七味白术散） on Glucose and Lipid Metabolism and Intestinal Flora in Obesity Patients of Spleen Deficiency and Dampness Disturbing Type
- Journal of Traditional Chinese Medicine Vol. 61, Issue 23, Pages: 2082-2086(2020)
- 作者机构：
  
  无锡市中医医院/南京中医药大学无锡附属医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2020.23.013
  CLC： R259
- Published：2020
- 稿件说明：
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[1]刘玲,陆西宛,何珂,朱丽华.七味白术散对脾虚湿困型肥胖症患者糖脂代谢及肠道菌群的影响[J].中医杂志,2020,61(23):2082-2086.

LIU Ling, LU Xiyuan, HE Ke, et al. Effects of Qiwei Baizhu Powder （七味白术散） on Glucose and Lipid Metabolism and Intestinal Flora in Obesity Patients of Spleen Deficiency and Dampness Disturbing Type[J]. Journal of Traditional Chinese Medicine2020, 61(23): 2082-2086.
[1]刘玲,陆西宛,何珂,朱丽华.七味白术散对脾虚湿困型肥胖症患者糖脂代谢及肠道菌群的影响[J].中医杂志,2020,61(23):2082-2086. DOI： 10.13288/j.11-2166/r.2020.23.013.

LIU Ling, LU Xiyuan, HE Ke, et al. Effects of Qiwei Baizhu Powder （七味白术散） on Glucose and Lipid Metabolism and Intestinal Flora in Obesity Patients of Spleen Deficiency and Dampness Disturbing Type[J]. Journal of Traditional Chinese Medicine2020, 61(23): 2082-2086. DOI： 10.13288/j.11-2166/r.2020.23.013.

摘要

目的评价七味白术散治疗脾虚湿困型肥胖症的临床疗效。方法 34例脾虚湿困型肥胖症患者随机分为治疗组（24例）与对照组（10例）。对照组患者给予指导生活方式、控制并规律饮食、适当运动锻炼干预;治疗组患者在对照组治疗基础上给予七味白术散口服

每日1剂。两组疗程均为3个月。比较两组治疗前后中医证候积分、体重指数（BMI）、血脂[包括甘油三酯（TG）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）]、糖代谢指标[包括空腹血糖（FBG）、空腹胰岛素（FINS）、糖化血红蛋白（HbA1c）、胰岛素抵抗指数（HOMA-IR）]以及肠道菌群分布变化。结果治疗组治疗后中医证候积分、BMI、FINS、HOMA-IR、FBG、TG均较治疗前明显降低

HDL明显升高（P<0.05或P<0.01）

而对照组治疗前后各指标差异均无统计学意义（P>0.05）。肠道菌群结果显示

在门水平

治疗组治疗前后拟杆菌门增幅高于对照组拟杆菌门增幅（P<0.05）

而厚壁菌门、变形杆菌门、放线菌门和梭形杆菌门两组间差异均无统计学意义（P>0.05）。在属水平

治疗组拟杆菌属、普雷沃菌属治疗后较治疗前有明显上升

拟普雷沃菌属较治疗前显著下降（P<0.05）。结论七味白术散可有效调节脾虚湿困型肥胖症患者肠道菌群分布

改善血糖、血脂代谢。

Abstract

Objective To evaluate the clinical efficacy of Qiwei Baizhu Powder（七味白术散） in the treatment of obesity of spleen deficiency and dampness disturbing. Methods A total of 34 obese patients with spleen deficiency and dampness disturbing were randomly divided into a treatment group（24 cases） and a control group（10 cases）. Patients in the control group were given guidance on lifestyle

controlled and regular diet

and appropriate exercise intervention; patients in the treatment group were additionally given Qiwei Baizhu Powder orally

1 dose per day. The course of treatment for both groups was 3 months. The scores of traditional Chinese medicine（TCM） syndromes

body mass index（BMI）

blood lipids including triglycerides（TG）

low-density lipoprotein（LDL） and high-density lipoprotein（HDL）

glucose metabolism indicators including fasting blood glucose（FBG）

fasting insulin（FINS）

glycosylated hemoglobin A1 c（HbA1 c）

insulin resistance index（HOMA-IR） and changes in the distribution of intestinal flora before and after treatment were compared. Results The scores of TCM syndromes

BMI

FINS

HOMA-IR

FBG

and TG in the treatment group were significantly lower than before treatment

and HDL was significantly increased（P<0.05 or P<0.01）. There was no statistical difference in all indicators in the control group before and after treatment（P>0.05）. The results of intestinal flora showed that at the phylum level

the increase of Bacteroides in the treatment group after treatment was higher than the that in the control group（P<0.05）. There was no statistically significant difference between groups in Bacillus phylum Firmicutes

Proteobacteria

Actinomycetes and Fusiform（P>0.05）. At the genus level

the Bacteroides and Prevotella in the treatment group increased significantly after treatment. Prevotella spp. was significantly decreased after treatment（P<0.05）. Conclusion Qiwei Baizhu Powder can effectively regulate the distribution of intestinal flora in obese patients with spleen deficiency and dampness disturbing

and can improve blood sugar and blood lipid metabolism.

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