Objective To analyze the clinical characteristics of patients with Coronavirus Disease 2019（COVID-19） that have continued to have positive nucleic acid result for more than 4 weeks. Methods A retrospective analysis method was used to enroll a total of 30 patients with COVID-19 who were admitted to the South First Ward of Wuhan Jinyintan Hospital from January 28 to March 30

2020

who had a positive duration of nucleic acid test of the novel coronavirus and lasted more than 4 weeks. General information

clinical data were collected and distribution of clinical characteristics and physical types of patients were analyzed. Results Among the 30 patients with COVID-19

10 patients were continuously positive and failed to be discharged

and 20 patients were rechecked after discharge or isolation therapy. Age of the patients were 34-86 years old

average（60.40±14.46） years old

19 cases（63.3%） ≥60 years old; clinical classification: 8 cases（26.7%） were of ordinary type

22 cases（73.3%） of severe type; main underlying diseases: 14 cases were of hypertension（46.6%）

6 cases of diabetes（20.0%）

5 cases of coronary heart disease（16.7%）; the main symptoms at the initial onset including fever（20 cases

66.7%）

wheezing（10 cases

33.3%）

cough（7 cases

23.3%）; throat swab nucleic acid repeated positive 24 times（80.0%）

sputum nucleic acid repeated positive 16 times（53.3%）; 24 cases received antibiotic treatment（80.0%）

16 cases（53.4%） received antiviral drug treatment

25 cases（83.3%） received traditional Chinese medicine treatment; 19 cases（63.3%） had dull tongue

11 cases（36.7%） had red tongue; 21 cases（70.0%） with greasy tongue coating

5 cases（16.7%） with less tongue coating

4 cases（13.3%） with thin and white coating; 12 cases（40.0%） were of phlegm constitution

8 cases of qi depression constitution（26.7%）

5 cases（16.6%） of qi deficiency constitution

3 cases（10.0%） of damp-heat constitution

2 cases（6.7%） of yin deficiency constitution. Conclusion There are relatively more patients with persistently positive nucleic acid of the novel coronavirus in the elderly and those with underlying diseases. Hypertension is the most common combined underlying disease

and repeated positive throat swabs are the most common; those with dull tongue and greasy tongue coating

as well as phlegm and dampness were most common. There are many patients with qi stagnation physique

so it is the direction of its treatment to invigorate qi and reinforce the vitality

dispel dampness and exorcise evil

regulate the qi machine.