The concept of "stasis and toxins causing diseases" is a major theory to explain the incidence and progression of coronary heart disease（CHD）. Moreover

improper emotions and minds（constraints） can also cause CHD

especially those with anxiety and depression. Pathogenic stasis

toxins and constraints often combine together

making the condition worse and refractory to the treatment. This paper explained the connotation of stasis

toxins and constraints

and their roles in the pathogenesis of CHD with anxiety and depression. The relationship between stasis-toxins

stasis-constraints

toxins-constraints were analyzed

and the pathogenesis of the binding of them were discussed. It was found that the binding and mutual influence of stasis

toxins and constraints was the core pathogenesis of CHD with anxiety and depression. Therefore

blood-invigorating

toxins-resolving

and constraints-discharging methods should be used simultaneously

and adjusted based on the different degree of stasis

toxins and constraints

in the treatment of CHD with anxiety and depression.