ZHANG Hui, HE Qingyong, DAI Shuang, et al. Factor Analysis of the Distribution of Pattens Elements and Disease Location in 680 Patients with Coronary Heart Disease and Dyslipidemia[J]. Journal of Traditional Chinese Medicine2021, 62(3): 240-245.
ZHANG Hui, HE Qingyong, DAI Shuang, et al. Factor Analysis of the Distribution of Pattens Elements and Disease Location in 680 Patients with Coronary Heart Disease and Dyslipidemia[J]. Journal of Traditional Chinese Medicine2021, 62(3): 240-245.DOI: 10.13288/j.11-2166/r.2021.03.012.
Factor Analysis of the Distribution of Pattens Elements and Disease Location in 680 Patients with Coronary Heart Disease and Dyslipidemia
Objective To explore the distribution of patten elements and disease location in patients with coronary heart disease and dyslipidemia. Methods The clinical data on symptoms
signs
tongue and pulse manifestation of 680 patients with coronary heart disease and dyslipidemia were collected and dealt with as dichotomous variables. Thereafter
a database matrix was constructed through Excel 2019 software. Factor analysis was performed to investigate the distribution of patten elements and disease location of the patients. Results Eighty-four variables in close relationship with coronary heart disease and dyslipidemia were included
including 60 symptoms and signs
and 24 tongue and pulse manifestation variables. Chest tightness(461 times
67.79%)
insomnia(302 times
44.41%)
and dizziness(229 times
43.97%) were the most frequent symptoms and signs; purple dusky tongue was most commonly seen for the tongue body(408 times
60.00%); white(326 times
47.94%) and greasy(298 times
43.82%) were the most frequent color and texture of the tongue coating. Wiry pulse(345 times
50.74%) had the highest frequency of all pulse manifestations. The common factors with eigenvalue greater than 1.0 rule were retained
and varimax rotation method was used. Totally
36 common factors were extracted
accounting for 63.39% of the variance contribution rate; 13 patten elements and seven disease locations were inducted. According to the patients score of each common factor
the main patten elements were phlegm-turbidity(460 cases
67.65%)
essence deficiency(117 cases
17.21%)
internal heat(82 cases
12.06%)
and yang deficiency(65 cases
9.56%); the main disease locations were spleen(504 cases
74.12%)
lung(309 cases
45.44%)
and kidney(174 cases
25.29%). Conclusion The pathogenesis of coronary heart disease with dyslipidemia is root deficiency and branch excess
with deficiency-excess complex. The excess patten elements is phlegm
while the deficiency patten elements include yang deficiency
essence deficiency
and yin deficiency. The main disease locations are spleen
Analysis of Clinical and Phenomics Characteristics of Patients with Phlegm-Stasis Binding Syndrome and Its Accompanied Patterns in Stable Angina Pectoris of Coronary Heart Disease
Pathogenesis Evolution and Staged Differentiation and Treatment Strategy of Atherosclerotic Plaques:from the Perspective of "Constraint-Putrefaction-Ulceration"
Effects of Yangxin Tongmai Formula (养心通脉方) on Methylation Key Genes and the PERK/ATF4/CHOP Signaling Pathway in Myocardial Tissue of Coronary Heart Disease Model Rats with Blood Stasis Syndrome
Construction of a Diagnostic Model for Coronary Heart Disease with Blood Stasis Syndrome Based on Objective Multi-Modal Data Fusion
Pathogenesis Characteristics and Progression Patterns of Liver Fibrosis in 644 Patients with Chronic Hepatitis B
Related Author
LI Chongchai
LI Han
LI Zheng
LI Zeng
ZHOU Yushi
AO Yuhan
XU Shuang
WANG Xue
Related Institution
Liaoning University of Traditional Chinese Medicine
Shenyang Health Service Center
Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
Clinical Evaluation Center,China Academy of Chinese Medical Sciences
Dongfang Hospital,Beijing University of Chinese Medicine