"Inflammation-cancer transformation" may explain the mechanism in the pathogenesis and progre-ssion of precancerous lesions of gastric cancer（PLGC）. Spleen and stomach damp-heat and PLGC "inflammation-cancer transformation" are similar in terms of etiology

and both have the pathogenic characteristics of inducing cancer

easily damaging healthy qi and flowing into other Zang（脏） organs. If spleen and stomach damp-heat and inflammatory microenvironment continue to exist

the internal environment of the body will be affected

thereby reducing the body′s ability to resist pathogens

and ultimately leading to the malignant progression of PLGC. The pathogenesis of spleen and stomach damp-heat is an important internal mechanism for the "inflammation-cancer transformation" of PLGC

which can be induced either by external contraction of damp-heat damaging the stomach collaterals

or by internal damage of the spleen and stomach leading to pathogen predominance and healthy qi depletion

or by pathogenic toxin of static heat constraint in the late stage of the disease bringing about progressions.