Based on the clinical characteristics of chidlren tic disorder

this paper discussed the traditional Chinese medicine（TCM） pathogenesis of tic disorder from the axis of "liver-qi and blood-sinew membranes"

that is

"the functions of zang-fu（脏腑） organs-substance essence-disease location of five body constituents". With reference to the classic theories of "tough sinews" and "liver governing sinew-membranes"

it is proposed that the core pathogenesis of tic disorder is the dysfunction of liver in governing sinew-membranes

leading to apraxia of sinews. The pathogenic process is as follows: owing to externally-contracted six pathogenic factor

irregular diet

internal emotional damage

genetic and congenital factors

the function of the five zang organs are damaged; deficiency may cause insufficiency of qi

blood

essence and body fluids

making sinews loss of moisture or warmth; excess will disturb the transportation and distribution of cereal essence and induce constraints which can be transformed into wind

phlegm and fire

and the contention among them will obstruct the channel passages

thereby making the sinews loss of nourishing and leading twitch. The core disease location of zang-fu organs lies in liver

in close interaction with spleen

lung

heart and kidney; the disease location of five body constituents is sinews

which is most closely related to muscles.