Objective

2

To evaluate the clinical effectiveness and safety of sequential triple therapy of Chinese herbal medicine for type 2 diabetes (T2D) based on real-world data.

Methods

2

Two hundred and five patients admitted to the five national hospitals from August 2018 to August 2020 were included

who met the diagnostic criteria of T2D and were given 12-week “sequential triple therapy” of Chinese herbal medicine (specific formula to specific syndrome based on fasting blood glucose (FBG) and 2-hour postprandial glucose (2hPG); specific medicine to specific disease for different stages; specific medicated tea to specific disease used alone or in combination as a circle and in a dynamic treatment way). FBG

2hPG

fructosamine (FMN)

glycosidated hemoglobin (HbA1c)

total cholesterol (TC)

triglyceride (TG)

low density lipoprotein cholesterol (LDL-C)

high density lipoprotein cholesterol (HDL-C)

insulin resistance index (IRI)

insulin sensitivity index (IRI)

and safety indicators were assessed before and after treatment.

Results

2

There were three drop-outs

and finally 252 patients were included. The levels of FBG

2hPG

FMN

HbA1c TC

TG and IRI decreased significantly (

P

＜ 0.05

P

＜ 0.01)

while the levels of HDL-C and ISI increased significantly after treatment than before treatment (

P

＜ 0.05). Eight mild gastrointestinal reactions occurred during treatment and were improved when the medication dose was reduced.

Conclusion

2

Sequential triple therapy of Chinese herbal medicine can regulate the blood glucose and lipid simultaneously by improving insulin resistance and increasing insulin sensitivity

and it has good safety.