Objective

2

To explore the clinical effectiveness and safety of

Longmu Jiawei Decoction

(龙牡加味汤

LJD) in the treatment of moderate to severe atopic dermatitis (AD) with heat accumulation due to wind-damp (HAW) syndrome.

Methods

2

Sixty-four moderate to severe AD patients with HAW syndrome were randomly divided into treatment group and control group

each with 32 cases. The treatment group was given oral administration and hydropathic cold compress of LJD

while the control group was treated with oral loratadine and external application of glucocorticoid; the course of treatment was 8 weeks. The scoring atopic dermatitis (SCORAD) tool was used to assess the rash area

severity

itching index and sleep disturbance

and the clinical effect was evaluated; the cured and markedly effective cases were followed up for 2 months to assess the recurrence rate; adverse reactions of both groups were recorded.

Results

2

There was one drop-off in the treatment group and two in the control group. Of the 31 cases in the treatment group

one case was cured; 12 cases were markedly effective; 15 cases were effective; and 3 cases were ineffective; the total effective rate was 90.32%. Of the 30 cases in the control group

no cases were cured

9 cases were markedly effective; 14 cases were effective

and 7 cases were ineffective

with a effective rate of 76.67%. There was significant difference between groups in the total effective rate (

P

＜0.05). The scores of rash area

rash severity

itching index

sleep disturbance and the total SCORDA score significantly decreased after treatment in both groups (

P

＜0.05)

and more decreases were seen in the treatment group than in the control group in terms of total SCORAD and the scores of rash area and rash severity (

P

＜0.05). Two out of 13 (15.38%) cured and markedly effective cases in the treatment group recurred

and there were five out of nine (55.56%) recurrence in the control group

with significant differences between groups (

P

＜0.05). No significant adverse reactions were found in both groups.

Conclusion

2

LJD has effects on moderate to severe AD

can significantly reduce the recurrence rate

and is safe.