Patients with Coronavirus Disease 2019 （COVID-19） and Type 2 Diabetes Treated by <italic style="font-style: italic">Qingfei Paidu Decoction</italic> （清肺排毒汤） in Combination with Western Medicine Routine Method：A Retrospective Study of 49 Cases

Liwen JIAO; Yuna GUO; Xingyu ZONG; Zhaoyuan GONG; Jingya WANG; Huizhen LI; Ning LIANG; Haili ZHANG; Yaxin CHEN; Xiaoling LI; Guoxiu LIU; Yan MA; Nannan SHI; Yanping WANG; Youwen GE

doi:10.13288/j.11-2166/r.2021.19.010

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Patients with Coronavirus Disease 2019 （COVID-19） and Type 2 Diabetes Treated by Qingfei Paidu Decoction （清肺排毒汤） in Combination with Western Medicine Routine Method：A Retrospective Study of 49 Cases

更新时间：2021-10-12

- Patients with Coronavirus Disease 2019 （COVID-19） and Type 2 Diabetes Treated by Qingfei Paidu Decoction （清肺排毒汤） in Combination with Western Medicine Routine Method：A Retrospective Study of 49 Cases
- Journal of Traditional Chinese Medicine Vol. 62, Issue 19, Pages: 1709-1714(2021)
- 作者机构：
  
  1.中国中医科学院中医临床基础医学研究所，北京市东城区东直门内南小街16号，100700
  2.中国中医科学院广安门医院
  3.北京中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2021.19.010
  CLC：
- Received：21 June 2021，
  
  Revised：2021-07-26，
  
  Published：02 October 2021
- 稿件说明：
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焦丽雯,郭玉娜,宗星煜等.清肺排毒汤联合西医常规疗法治疗新型冠状病毒肺炎合并2型糖尿病患者49例回顾性临床研究[J].中医杂志,2021,62(19):1709-1714.

JIAO Liwen,GUO Yuna,ZONG Xingyu,et al.Patients with Coronavirus Disease 2019 （COVID-19） and Type 2 Diabetes Treated by Qingfei Paidu Decoction （清肺排毒汤） in Combination with Western Medicine Routine Method：A Retrospective Study of 49 Cases[J].Journal of Traditional Chinese Medicine,2021,62(19):1709-1714.
焦丽雯,郭玉娜,宗星煜等.清肺排毒汤联合西医常规疗法治疗新型冠状病毒肺炎合并2型糖尿病患者49例回顾性临床研究[J].中医杂志,2021,62(19):1709-1714. DOI： 10.13288/j.11-2166/r.2021.19.010.

JIAO Liwen,GUO Yuna,ZONG Xingyu,et al.Patients with Coronavirus Disease 2019 （COVID-19） and Type 2 Diabetes Treated by Qingfei Paidu Decoction （清肺排毒汤） in Combination with Western Medicine Routine Method：A Retrospective Study of 49 Cases[J].Journal of Traditional Chinese Medicine,2021,62(19):1709-1714. DOI： 10.13288/j.11-2166/r.2021.19.010.

摘要

目的

探讨清肺排毒汤治疗新型冠状病毒肺炎（简称新冠肺炎）合并2型糖尿病的疗效。

方法

回顾性收集2020年1月24日至3月17日8个省、自治区、直辖市17家医院确诊的新冠肺炎合并2型糖尿病患者的临床资料，所有患者均服用清肺排毒汤至少6天。比较治疗前及治疗第3天、第6天患者主要临床症状（包括发热、咳嗽、干咳、乏力、厌食、气喘）分布，治疗前及治疗第6天实验室异常指标病例数及肺部病灶分布情况，新型冠状病毒核酸转阴时间及住院时间，记录不良反应发生情况及治疗转归。

结果

共纳入新冠肺炎合并2型糖尿病患者49例。与治疗前比较，治疗第3天、第6天有发热、咳嗽、乏力症状的病例数明显减少，差异具有统计学意义（

＜0.05）。治疗前肺部CT影像结果显示47例患者呈现不同程度的肺部病变，治疗第6天有41例患者呈现不同程度肺部病变，治疗前后肺部病灶分布差异无统计学意义（

＞0.05）。与治疗前比较，治疗第6天患者C反应蛋白升高、血沉升高、丙氨酸氨基转移酶升高、门冬氨酸氨基转移酶升高、淋巴细胞计数减少、白细胞计数升高的病例数差异均无统计学意义（

＞0.05）。患者新型冠状病毒核酸转阴时间平均为11（8，15）天，住院时间平均为18（14，23）天，治疗期间未发生严重不良反应，全部患者均痊愈出院。

结论

在西医常规治疗基础上联合使用清肺排毒汤可有效缓解新冠肺炎合并2型糖尿病患者发热、咳嗽、乏力等症状，可加快新型冠状病毒核酸转阴，且无严重不良反应，具有较好的预后。

Abstract

Objective

To explore the effect of

Qingfei Paidu Decoction

(清肺排毒汤

QPD) in the treatment of coronavirus disease 2019 (COVID-19) concomitant with type 2 diabetes (T2D).

Methods

Clinical data was retrospectively collected from patients confirmed with COVID-19 with T2D and admitted to 17 hospitals in eight provinces/autonomous regions/municipalities from January 24 to March 17

2020. Patients were included if they had taken QPD for at least 6 days. The clinical symptoms (fever

cough

dry cough

fatigue

anorexia

and asthma) were assessed before treatment and at day 3 and day 6 after treatment; the improvement of laboratory abnormal indicators were recorded before treatment and at day 6 after treatment; the time to negative conversion of nucleic acid test result

the duration of hospital stay

adverse reactions

and end-point outcomes were assessed.

Results

A total of 49 patients of COVID-19 with T2D were included. Compared to those before treatment

the number of fever

cough and fatigue were significantly reduced at day 3 and day 6 during treatment

and the difference was statistically significant (

＜0.05). The results of lung CT images showed that 47 patients had different degrees of lung lesions before treatment

and the number decreased to 41 at day 6 during treatment

with no significant difference (

＞0.05). Compared to those before treatment

the number of patients with elevated C-reactive protein

elevated erythrocyte sedimentation rate

elevated alanine aminotransferase

elevated aspartate aminotransferase

decreased lymphocyte count

and elevated white blood cell count showed no statistically changes at day 6 during treatment (

＞0.05). The medium time to negative conversion of nucleic acid test result was 11 (8

15) days

and the medium duration of hospital stay was 18 (14

23) days. No serious adverse events occurred during treatment. All patients were cured and discharged from hospitals.

Conclusion

The use of QPD in addition to conventional western medicine routine method can effectively alleviate the symptoms of fever

cough

fatigue and other symptoms and promote the negative conversion of nucleic acid test result in COVID-19 patients concomitant with T2D

with no serious adverse reactions and having preferred prognosis.

关键词

Keywords

references

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Patients with Coronavirus Disease 2019 （COVID-19） and Type 2 Diabetes Treated by Qingfei Paidu Decoction （清肺排毒汤） in Combination with Western Medicine Routine Method：A Retrospective Study of 49 Cases

DOI：10.13288/j.11-2166/r.2021.19.010

摘要

Abstract

关键词

Keywords

references