XING Yaxuan,ZHANG Jingchun,AI Yuzhen,et al.XING Yaxuan1, ZHANG Jingchun2, AI Yuzhen2, ZHANG Shan1, YAN Longmei1[J].Journal of Traditional Chinese Medicine,2021,62(23):2092-2097. DOI: 10.13288/j.11-2166/r.2021.23.013.
XING Yaxuan,ZHANG Jingchun,AI Yuzhen,et al.XING Yaxuan1, ZHANG Jingchun2, AI Yuzhen2, ZHANG Shan1, YAN Longmei1[J].Journal of Traditional Chinese Medicine,2021,62(23):2092-2097. DOI: 10.13288/j.11-2166/r.2021.23.013.DOI:
Analysis on the Medication Rules of Formulas for Universal Relief(《普济方》)in Treating Chest Bì(痹)and Heartache through Data Mining
(《普济方》), and to analyze its medication rules based on the data mining technology.
Methods
2
The prescriptions for treating chest
bì
and heartache in the
Formulas for Universal Relief
were screened, and the corresponding database was built. Based on the V2.5.0 software of Traditional Chinese Medicine (TCM) Inheritance System,the collected prescriptions were analyzed through frequency analysis, association rule analysis and entropy clustering analysis.
Results
2
Totally 126 prescriptions were included, involving 127 medicinal herbs. The most frequently used herbs were Rougui (
Cortex Cinnamomi,
69 times), Gancao (
Radix et Rhizoma Glycyrrhizae,
39 times), Ganjiang (
Rhizoma Zingiberis,
33 times), Wuzhuyu (
Fructus Evodiae,
31 times). In terms of the medicinal nature, the drugs were mainly warm (51.3%) and hot (22.7%); the medicinal flavor was mainly acrid (41.2%); most herbs entered into the spleen meridian (23.2%). According to the association rules analysis, 15 drug pairs with support degree≥15 were obtained, among which the top three were Ganjiang-Rougui, Gancao-Rougui, and Rougui-Wuzhuyu. According to the association rules, 11 drug pairs with confidence ≥ 0.6 were obtained, and the top three were Xixin (
Radix et Rhizoma Asari
)-Rougui, Renshen (
Radix et Rhizoma Ginseng
)-Rougui, and Baizhu (
Rhizoma Atractylodis Macrocephalae
)-Rougui. Six groups of core herbs and three new prescriptions were obtained by entropy clustering algorithm, and most of the herbs used in new prescriptions have the effects of warming
Yang
, strengthening the center, rectifying
qi
and invigorating blood.
Conclusion
2
The Medicaton rules for treating chest
bi
and heartache in the
Formulas for Universal Relief
are focusing on warming methods, treating the heart and spleen, and the
World Health Organization . The top 10 causes of death [R/OL].( 2020-12-09 ) [ 2020-12-15 ]. https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death .
LI W , ZHI W , LIU F , et al . Atractylenolide I restores HO-1 expression and inhibits Ox-LDL-induced VSMCs proliferation, migration and inflammatory responses in vitro [J]. Exp Cell Res , 2017 , 353 ( 1 ): 26 - 34 .