Strategy for Addressing Heterogeneity in Systematic Reviews and Meta-analyses of Traditional Chinese Medicine： the Application of Meta-regression Approach

Shibing LIANG; Jianping LIU; Qianyun CHAI; Zihao HE; Kai GAO; Ying ZHANG

doi:10.13288/j.11-2166/r.2022.08.009

您当前的位置：

首页 >

文章列表页 >

Strategy for Addressing Heterogeneity in Systematic Reviews and Meta-analyses of Traditional Chinese Medicine： the Application of Meta-regression Approach

更新时间：2022-04-11

- Strategy for Addressing Heterogeneity in Systematic Reviews and Meta-analyses of Traditional Chinese Medicine： the Application of Meta-regression Approach
  增强出版
- Journal of Traditional Chinese Medicine Vol. 63, Issue 8, Pages: 739-744(2022)
- 作者机构：
  
  1.北京中医药大学循证医学中心，北京市朝阳区北三环东路11号，100029
  2.北京中医药大学中医学院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2022.08.009
  CLC：
- Received：04 July 2021，
  
  Revised：2021-12-29，
  
  Published：17 April 2022
- 稿件说明：
移动端阅览
梁士兵,刘建平,柴倩云等.中医药系统综述与Meta分析中异质性来源与处理——Meta回归在中医药领域的应用[J].中医杂志,2022,63(08):739-744.

LIANG Shibing,LIU Jianping,CHAI Qianyun,et al.Strategy for Addressing Heterogeneity in Systematic Reviews and Meta-analyses of Traditional Chinese Medicine： the Application of Meta-regression Approach[J].Journal of Traditional Chinese Medicine,2022,63(08):739-744.
梁士兵,刘建平,柴倩云等.中医药系统综述与Meta分析中异质性来源与处理——Meta回归在中医药领域的应用[J].中医杂志,2022,63(08):739-744. DOI： 10.13288/j.11-2166/r.2022.08.009.

LIANG Shibing,LIU Jianping,CHAI Qianyun,et al.Strategy for Addressing Heterogeneity in Systematic Reviews and Meta-analyses of Traditional Chinese Medicine： the Application of Meta-regression Approach[J].Journal of Traditional Chinese Medicine,2022,63(08):739-744. DOI： 10.13288/j.11-2166/r.2022.08.009.

摘要

中医药系统综述与Meta分析中的临床异质性来源于可能导致不同研究间干预效果差异的某些因素，包括受试者、干预措施以及对照措施等方面。在进行中医药疗效和安全性系统综述与Meta分析时，必须采取适当措施对不同研究间的异质性进行检验、处理及解释。Meta回归是用来探索不同研究间异质性大小及来源的常用定量分析方法，可以探索不同中医临床研究间异质性的大小及来源，并进一步阐释异质性对Meta分析中合并效应的影响。对中医药疗效和安全性系统综述与Meta分析中的异质性概念、分类、来源以及常用检验方法（包括图示法和定量统计分析方法），Meta回归（meta-regression）的概念、作用、优势及使用注意事项等进行了介绍，并以实例介绍了采用R语言的metafor包实现中医药疗效和安全性系统综述与Meta分析中异质性检验、Meta回归的具体操作过程和结果解读方法。

Abstract

The clinical heterogeneity in systematic reviews （SRs） and meta-analyses of traditional Chinese medicine （TCM） originates from certain factors， such as participants， intervention and control， that may lead to intervention effects being different among each study. When SRs and meta-analyses are conducted to explore the effectiveness and safety of TCM， it is necessary to explore and deal with the between-study heterogeneity with appropriate approaches. Meta-regression is a quantitative method commonly used to explore the extent and source of between-study heterogeneity， as well as its impact on pooled effects. This paper introduces the definition， categories， and sources of heterogeneity， and summarizes the common methods used to address heterogeneity including graphical and quantitative statistical analyses. Meta-regression approach including its definition， function， advantages and precautions is also introduced. Moreover， an example of using metafor package of R language to explore the heterogeneity in SRs and meta-analyses of TCM has been taken， by providing the procedure steps and the interpretation of the results.

关键词

Keywords

references

刘建平 . 循证中医药临床研究方法［M］. 2版 . 北京：人民卫生出版社， 2019 ： 179 .

HIGGINS JPT ， THOMAS J ， CHANDLER J ， et al . Cochrane Handbook for Systematic Reviews of Interventions version 6.2 ［EB/OL］. （ 2021-02-01 ）［ 2021-07-04 ］. www.training.cochrane.org/handbook www.training.cochrane.org/handbook .

HIGGINS JPT ， THOMPSON SG ， DEEKS JJ ， et al . Measuring inconsistency in meta-analyses ［J］. BMJ ， 2003 ， 327 （ 7414 ）： 557 - 560 .

SONG F ， SHELDON TA ， SUTTON AJ ， et al . Methods for exploring heterogeneity in meta-analysis ［J］. Eval Health Prof ， 2001 ， 24 （ 2 ）： 126 - 151 .

THOMPSON SG ， SHARP SJ . Explaining heterogeneity in meta-analysis： a comparison of methods ［J］. Stat Med ， 1999 ， 18 （ 20 ）： 2693 - 2708 .

IOANNIDIS J ， PATSOPOULOS N ， ROTHSTEIN H . Reasons or excuses for avoiding meta-analysis in forest plots ［J］. BMJ ， 2008 ， 336 （ 7658 ）： 1413 - 1415 .

SUTTON AJ ， HIGGINS JPT . Recent developments in meta-analysis ［J］. Stat Med ， 2008 ， 27 （ 5 ）： 625 - 650 .

BAKER WL ， WHITE CM ， CAPPELLERI JC ， et al . Understanding heterogeneity in meta-analysis： the role of meta-regression ［J］. Int J Clin Pract ， 2009 ， 63 （ 10 ）： 1426 - 1434 .

TIPTON E ， PUSTEJOVSKY JE ， AHMADI H . A history of meta-regression： technical， conceptual， and practical developments between 1974 and 2018 ［J］. Res Synth Methods ， 2019 ， 10 （ 2 ）： 161 - 179 .

VIECHTBAUER W . Conducting meta-analyses in R with the metafor package ［J］. J Statist Soft ， 2010 ， 36 （ 3 ）： 1 - 48 .

MANTEL N ， HAENSZEL W . Statistical aspects of the analysis of data from retrospective studies of disease ［J］. J Natl Cancer Inst ， 1959 ， 22 （ 4 ）： 719 - 748 .

YUSUF S ， PETO R ， LEWIS J ， et al . Beta blockade during and after myocardial infarction： an overview of the randomized trials ［J］. Prog Cardiovasc Dis ， 1985 ， 27 （ 5 ）： 335 - 371 .

L'ABBÉ KA ， KRISTAN A ， DETSKY ， et al . Meta-analysis in clinical research ［J］. Ann Intern Med ， 1987 ， 107 （ 2 ）： 224 - 233 .

张天嵩，刘江波，钟文昭 . Stata在探索异质性来源： Meta回归分析中的应用［J］. 循证医学， 2009 ， 9 （ 1 ）： 48 - 50 .

王家良 . 循证医学［M］. 北京：人民卫生出版社， 2005 ： 85 .

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effectiveness and Safety of Wangbi Preparations （尪痹制剂） Combined with Western Medicine for Rheumatoid Arthritis： A Systematic Review and Meta-analysis

Modified Mahuang Decoction （麻黄汤） Combined with Western Medicine Treatment for Acute Asthmatic Bronchitis: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Systematic Review and Meta-analysis of Efficacy and Safety of Massage in Treatment of Essential Hypertension

An AI-Driven Research Pathway for Upholding Fundamental Principles and Breaking New Ground of Traditional Chinese Medicine Under the Guidance of Complexity Science

Clinical Efficacy of Janus Kinase Inhibitors in Combination with Chinese Herbal Medicine for Rheumatoid Arthritis：A Retrospective Study and A Meta-analysis

Related Author

Xiangke QU

Jianrong SUN

Jing LUO

Huilan ZHENG

Jianming WANG

QIN Yiwen

LIU Ying

CHEN Ming

Related Institution

Graduate School，Beijing University of Chinese Medicine

Japan Friendship Hospital

School of Chinese Medicine, Beijing University of Chinese Medicine

Evidence Based Medicine Center,Beijing University of Chinese Medicine

College of Traditional Chinese Medicine,Beijing University of Chinese Medicine

Address：No.16, Nanxiao street, Dongzhimen, Dongcheng District, Beijing Postal code：100700
Tel：010-64035632 Email：jtcmcn@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010102007558号
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰