Characteristics of Traditional Chinese Medicine Syndromes in Multiple System Atrophy and Its Correlation with the Level of Hemoglobin-binding α-synuclein

Xinning ZHANG; Weizheng RAN; Wenyang TIAN; Sushi WANG; Shun YU; Yao WANG; Bingyu GUO; Xianke LUO; Zhigang CHEN

doi:10.13288/j.11-2166/r.2022.13.013

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Characteristics of Traditional Chinese Medicine Syndromes in Multiple System Atrophy and Its Correlation with the Level of Hemoglobin-binding α-synuclein

更新时间：2022-06-24

- Characteristics of Traditional Chinese Medicine Syndromes in Multiple System Atrophy and Its Correlation with the Level of Hemoglobin-binding α-synuclein
- Journal of Traditional Chinese Medicine Vol. 63, Issue 13, Pages: 1265-1270(2022)
- 作者机构：
  
  1.北京中医药大学，北京市朝阳区北三环东路11号，100029
  2.北京中医药大学东方医院
  3.中国人民解放军总医院第一医学中心
  4.中国中医科学院广安门医院
  5.首都医科大学附属北京中医医院
  6.首都医科大学附属宣武医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2022.13.013
  CLC：
- Received：09 October 2021，
  
  Revised：2022-03-22，
  
  Published：02 July 2022
- 稿件说明：
移动端阅览
张新宁,冉维正,田文杨等.多系统萎缩患者中医证候特点及其与血红蛋白结合α-突触核蛋白的相关性分析[J].中医杂志,2022,63(13):1265-1270.

ZHANG Xinning,RAN Weizheng,TIAN Wenyang,et al.Characteristics of Traditional Chinese Medicine Syndromes in Multiple System Atrophy and Its Correlation with the Level of Hemoglobin-binding α-synuclein[J].Journal of Traditional Chinese Medicine,2022,63(13):1265-1270.
张新宁,冉维正,田文杨等.多系统萎缩患者中医证候特点及其与血红蛋白结合α-突触核蛋白的相关性分析[J].中医杂志,2022,63(13):1265-1270. DOI： 10.13288/j.11-2166/r.2022.13.013.

ZHANG Xinning,RAN Weizheng,TIAN Wenyang,et al.Characteristics of Traditional Chinese Medicine Syndromes in Multiple System Atrophy and Its Correlation with the Level of Hemoglobin-binding α-synuclein[J].Journal of Traditional Chinese Medicine,2022,63(13):1265-1270. DOI： 10.13288/j.11-2166/r.2022.13.013.

摘要

目的

探索多系统萎缩（MSA）患者中医证候特点及中医证候与红细胞中血红蛋白结合α-突触核蛋白（Hb-α-syn）含量的相关性。

方法

纳入MSA患者作为MSA组，另选取同时期性别分布及年龄情况匹配的健康体检者作为健康对照组，各149例。收集患者临床资料，并进行中医证候评分、统一多系统萎缩评定量表（UMSARS）评分，检测MSA组及健康对照组外周血红细胞Hb-α-syn含量。采用Spearman相关性分析探讨MSA组患者中医证候主证积分与发病年龄、病程、UMSARS评分的相关性，Hb-α-syn含量与MSA患者发病年龄、病程、UMSARS评分、中医证候积分的相关性。

结果

MSA组红细胞中Hb-α-syn含量平均为（194.01±58.27）µg/ml，健康对照组为（143.12±44.01）µg/ml，MSA组Hb-α-syn含量较健康对照组显著升高（

＜0.01）。143例MSA组患者完成了中医证候信息采集，主证中肾虚证患者140例，其中肾气虚94例、肾阳虚33例、肾阴虚13例；兼证中痰湿证56例，瘀血证54例。140例肾虚主证患者中医证候积分平均（23.02±6.33）分，痰湿证平均（5.99±3.45）分，瘀血证平均（4.92±2.35）分。149例MSA患者UMSARS总分平均（43.95±16.71）分。MSA肾虚主证积分与病程、UMSARS总分正相关（

＜0.01），Hb-α-syn含量与发病年龄、病程、UMSARS评分、中医证候积分均无明显相关（

＞0.05）。

结论

MSA患者中医证候以肾气虚为主，红细胞中Hb-α-syn含量较健康人显著升高，但目前尚不能证实中医证候与Hb-α-syn含量具有相关性。

Abstract

Objective

To explore the traditional Chinese medicine （TCM） syndrome characteristics of multiple system atrophy （MSA） and its correlation with the level of hemoglobin-binding α-synuclein （Hb-α-syn） in erythrocytes.

Methods

The MSA patients were collected and set as the MSA group， and the healthy subjects matched with gender and age were selected as the control group， with 149 cases in each group. TCM syndrome score and the Unified Multiple System Atrophy Rating Scale （UMSARS） score were assessed， and the levels of Hb-α-syn in erythrocytes of the peripheral blood were detected. Spearman correlation analysis was used to explore the correlation between the score of the main TCM syndrome and the age of onset， course of disease， and UMSARS score in MSA patients， as well as the correlation between Hb-α-syn level and the age of onset， course of disease， UMSARS score， and TCM syndrome score.

Results

The average level of Hb-α-syn in erythrocytes of MSA group was 194.01±58.27 μg/ml， significantly higher than 143.12±44.01 μg/ml of the control group （

＜0.01）. Among the 143 MSA patients whose TCM syndrome information were collected， there were 140 cases of kidney deficiency as the main syndrome including 94 cases of kidney-

deficiency， 33 cases of kidney-

yang

deficiency， and 13 cases of kidney-

yin

deficiency； in terms of the combined syndrome， there were 56 cases of phlegm-dampness syndrome and 54 cases of blood stasis syndrome. The average TCM syndrome score of the 140 patients with the main syndrome of kidney deficiency was 23.02±6.33， while that of phlegm-dampness syndrome and blood stasis syndrome was 5.99±3.45 and 4.92±2.35， respectively. The average UMSARS total score of the 149 MSA patients was 43.95±16.71. The main syndrome score of kidney deficiency was positively correlated with the course of disease and the total score of UMSARS （

＜0.01）， while the level of Hb-α-syn had no significant correlation with the age of onset， course of disease， UMSARS score， and TCM syndrome score （

＞0.05）.

Conclusion

The kidney

deficiency syndrome is most commonly seen in MSA patients， and the level of Hb-α-syn in MSA patients is significantly higher than that of healthy people. However， the correlation between TCM syndromes and the Hb-α-syn level has not yet been determined.

关键词

Keywords

references

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