PAN Li,JING Hailiang,REN Yifeng,et al.Discussion on Treatment of Liver Metastasis of Colon Cancer with Traditional Chinese Medicine Based on the Theory of Liver and the Spleen Comorbidity[J].Journal of Traditional Chinese Medicine,2022,63(17):1638-1643.
PAN Li,JING Hailiang,REN Yifeng,et al.Discussion on Treatment of Liver Metastasis of Colon Cancer with Traditional Chinese Medicine Based on the Theory of Liver and the Spleen Comorbidity[J].Journal of Traditional Chinese Medicine,2022,63(17):1638-1643.DOI: 10.13288/j.11-2166/r.2022.17.008.
Discussion on Treatment of Liver Metastasis of Colon Cancer with Traditional Chinese Medicine Based on the Theory of Liver and the Spleen Comorbidity
Liver metastasis of colon cancer is a typical representative of the pathogenesis of liver and the spleen comorbidity. This paper expounded the pathogenesis of liver and the spleen comorbidity in liver metastasis of colon cancer from the perspectives of enterohepatic circulation, intestinal microecology and pre-metastatic mircroenviroment. It is further pointed out that the method of “simultaneous regulation of liver and the spleen” should run through the whole process of prevention and treatment of liver metastasis of colon cancer, mainly by fortifying and rectifying the spleen supplemented with soothing and softening the liver; the methods of dissolving phlegm, unblocking collate-rals, dissipating stasis, and resolving toxins and eliminating concretions can be combined.
Xiaoyao Powder
(逍遥散) and
Chaishao Liujunzi Decoction
(柴芍六君子汤) can be used. The core of the theory “liver and the spleen comorbidity” in guiding the treatment of liver metastasis of colon cancer is to regulate both the liver and spleen, and its mechanism may be delaying the development of the disease by restoring intestinal flora homeostasis, regulating immune imbalance and chronic inflammation.
TRIPATHI A , DEBELIUS J , BRENNER DA , et al . The gut-liver axis and the intersection with the microbiome [J]. Nat Rev Gastroenterol Hepatol , 2018 , 15 ( 7 ): 397 - 411 .
TERRY S , SAVAGNER P , ORTIZ-CUARAN S , et al . New insights into the role of EMT in tumor immune escape [J]. Mol Oncol , 2017 , 11 ( 7 ): 824 - 846 .
HU CT , GUO LL , FENG N , et al . MIF, secreted by human hepatic sinusoidal endothelial cells, promotes chemotaxis and outgrowth of colorectal cancer in liver prometastasis [J]. Oncotarget , 2015 , 6 ( 26 ): 22410 - 22423 .
ZHAO S , MI Y , GUAN B , et al . Correction to: tumor-derived exosomal miR-934 induces macrophage M2 pola-rization to promote liver metastasis of colorectal cancer [J]. J Hematol Oncol , 2021 , 14 ( 1 ): 33 .
SONG W , TIRUTHANI K , WANG Y , et al . Trapping of lipopolysaccharide to promote immunotherapy against colorectal cancer and attenuate liver metastasis [J]. Adv Mater , 2018 , 30 ( 52 ): e1805007 .
LU YT , LI J , QI X , et al . Effects of Shugan Jianpi Formula on myeloid-derived suppression cells-mediated depression breast cancer mice [J]. Chin J Integr Med , 2017 , 23 ( 6 ): 453 - 460 .
SCHEINMAN EJ , ROSTOKER R , LEROITH D . Cholesterol affects gene expression of the Jun family in colon carcinoma cells using different signaling pathways [J]. Mol Cell Endocrinol , 2013 , 374 ( 1/2 ): 101 - 107 .
Clinical Efficacy and Economic Evaluation of 1293 Non-Severe Adult Patients with Community-Acquired Pneumonia Treated by the Jiangsu Traditional Chinese Medicine Diagnosis and Treatment Protocol for Dominant Diseases:A Multicenter,Retrospective Real-World Cohort Study
Current Status and Strategic Recommendations for Randomized Controlled Trials on Functional Dyspepsia-Irritable Bowel Syndrome Comorbidity:from a Real-World Research Perspective
Challenges and Recommendations for Implementing Key Technologies in Decentralized Clinical Trials of Traditional Chinese Medicine
The Philosophy and Practical Pathway of "Dao (道)-Shen (神)-Formula" in Traditional Chinese Medicine
Effect of Xiaoqinglong Decoction (小青龙汤) on Th2 Immune Responses and Nasal Mucosal TSLP/OX40L Pathway in Allergic Rhinitis Model Rats