Analysis of Diabetes Mellitus-related TCM Research Projects Funded by National Natural Science Foundation of China from 2017 to 2021

Tianyuan LIU; Yage LIU; Xuan DAI; Meixi LU; Ruyuan ZHU; Shuzhen GUO; Lili WANG; Dongwei ZHANG

doi:10.13288/j.11-2166/r.2022.18.007

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Analysis of Diabetes Mellitus-related TCM Research Projects Funded by National Natural Science Foundation of China from 2017 to 2021

更新时间：2022-09-14

- Analysis of Diabetes Mellitus-related TCM Research Projects Funded by National Natural Science Foundation of China from 2017 to 2021
- Journal of Traditional Chinese Medicine Vol. 63, Issue 18, Pages: 1731-1739(2022)
- 作者机构：
  
  1.北京中医药大学中医学院，北京市朝阳区北三环东路11号，100029
  2.北京中医药大学中药学院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2022.18.007
  CLC：
- Received：21 January 2022，
  
  Revised：2022-07-11，
  
  Published：17 September 2022
- 稿件说明：
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刘田园,刘亚鸽,戴璇等.2017-2021年国家自然科学基金糖尿病相关中医药研究项目分析[J].中医杂志,2022,63(18):1731-1739.

LIU Tianyuan,LIU Yage,DAI Xuan,et al.Analysis of Diabetes Mellitus-related TCM Research Projects Funded by National Natural Science Foundation of China from 2017 to 2021[J].Journal of Traditional Chinese Medicine,2022,63(18):1731-1739.
刘田园,刘亚鸽,戴璇等.2017-2021年国家自然科学基金糖尿病相关中医药研究项目分析[J].中医杂志,2022,63(18):1731-1739. DOI： 10.13288/j.11-2166/r.2022.18.007.

LIU Tianyuan,LIU Yage,DAI Xuan,et al.Analysis of Diabetes Mellitus-related TCM Research Projects Funded by National Natural Science Foundation of China from 2017 to 2021[J].Journal of Traditional Chinese Medicine,2022,63(18):1731-1739. DOI： 10.13288/j.11-2166/r.2022.18.007.

摘要

目的

分析2017-2021年国家自然科学基金（NSFC）资助的糖尿病领域中医药相关项目情况，探讨中医药干预糖尿病的研究现状及发展趋势。

方法

利用国家自然科学基金委员会、梅斯医学、科研Z库的数据库，获得2017-2021年NSFC资助的糖尿病相关研究项目，提取其项目经费、中文关键词、用药与治则、相关机制和研究对象等信息并进行统计分析。

结果

近5年NSFC共资助糖尿病相关项目1546项；其中纳入研究的NSFC资助的糖尿病相关中医药研究项目324项。用药与治则分析结果显示探索补阳还五汤、糖肾方等抗糖尿病作用机制的项目相对较多；中（英）文关键词及项目研究对象分析结果均表明项目研究内容多集中在2型糖尿病及其并发症等方向，其中以糖尿病肾病（104项）、糖尿病溃疡创面愈合（17项）、糖尿病肠道菌群疾病（15项）、糖尿病周围神经病变（13项）、糖尿病心肌病（11项）、糖尿病性脑病（11项）较多。此外，研究项目多从自噬途径、炎症通路、内质网应激、线粒体途径、肠道菌群、氧化应激及外泌体等途径探索中医药防治糖尿病及其并发症的作用机制。

结论

近5年NSFC资助的糖尿病相关中医药项目多以探索临床有效的中药复方干预糖尿病及其并发症的作用机理为主。多学科、多技术交叉融合，将进一步为糖尿病及其并发症的中医药研究及临床应用提供依据。

Abstract

Objective

To analyze the diabetes mellitus （DM）-related traditional Chinese medicine （TCM） research projects funded by National Natural Science Foundation of China （NSFC） from 2017 to 2021， and to explore the research status and development trend of TCM interventions for DM.

Methods

The NSFC database， MedSci， and the Scientific Research Z Library were searched to obtain the DM-related projects funded by NSFC from 2017 to 2021. And the information including the project funding amount， Chinese keywords， medication and treatment principle， related mechanisms and research objects were collected for statistical analysis.

Results

In recent five years， NSFC has funded a total of 1546 DM-related projects， among which 324 projects were involved with TCM. The analysis of medication and treatment principles showed that many projects have explored the anti-diabetes mechanism of

Buyang Huanwu Decoction

（补阳还五汤） and

Tangshen Formula

（糖肾方）. Analysis of keywords in Chinese （English） and the research objects showed that type 2 diabetes mellitus and its complications were mostly studied， and the most common ones were diabetic nephropathy （104 projects）， diabetic ulcer wound healing （17 projects）， diabetic intestinal microbiota diseases （15 projects）， diabetic peripheral neuropathy （13 projects）， diabetic cardiomyopathy （11 projects）， and diabetic encephalopathy （11 projects）. In addition， autophagy pathway， inflammatory pathway， endoplasmic reticulum stress， mitochondrial pathway， gut microbiota， oxidative stress and exosome pathway were most commonly used to explore the mechanism of TCM in the prevention and treatment of DM and its complications.

Conclusion

In the past five years， most of the DM-related TCM projects funded by NSFC have been designed to explore the mechanism of clinically effective TCM compounds in intervening DM and its complications. The cross-integration of multi-disciplines and multi-technologies will also be beneficial to promoting the basic and clinical researches about TCM in the management of DM.

关键词

Keywords

references

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