Clinical Observation on Anterior Chamber Puncture Combined with Orifices-unblocking and Vision-improving Method for the Treatment of Retinal Artery Occlusion for More than 12 Hours with <italic style="font-style: italic">Qi</italic> Stagnation and Blood Stasis Syndrome： An analysis of 51 Cases

YUAN Hang; XIE Like; LUO Jie; HAO Xiaofeng; ZHANG Cangxia; ZHONG Shuyang; WU Lie; WU Gaiping; CHEN Ziyang

doi:10.13288/j.11-2166/r.2022.22.009

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Clinical Observation on Anterior Chamber Puncture Combined with Orifices-unblocking and Vision-improving Method for the Treatment of Retinal Artery Occlusion for More than 12 Hours with Qi Stagnation and Blood Stasis Syndrome： An analysis of 51 Cases

更新时间：2022-11-11

- Clinical Observation on Anterior Chamber Puncture Combined with Orifices-unblocking and Vision-improving Method for the Treatment of Retinal Artery Occlusion for More than 12 Hours with Qi Stagnation and Blood Stasis Syndrome： An analysis of 51 Cases
- Journal of Traditional Chinese Medicine Vol. 63, Issue 22, Pages: 2135-2140(2022)
- 作者机构：
  
  1.中国中医科学院眼科医院，北京市石景山区鲁谷路33号，100040
  2.河北省沧州中西医结合医院
  3.广西中医药大学第一附属医院
  4.中国中医科学院广安门医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2022.22.009
  CLC：
- Received：08 May 2022，
  
  Revised：2022-08-30，
  
  Published：17 November 2022
- 稿件说明：
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袁航,谢立科,罗傑等.前房穿刺联合通窍明目法治疗超过12小时视网膜动脉阻塞气滞血瘀型患者51例临床观察[J].中医杂志,2022,63(22):2135-2140.

YUAN Hang,XIE Like,LUO Jie,et al.Clinical Observation on Anterior Chamber Puncture Combined with Orifices-unblocking and Vision-improving Method for the Treatment of Retinal Artery Occlusion for More than 12 Hours with Qi Stagnation and Blood Stasis Syndrome： An analysis of 51 Cases[J].Journal of Traditional Chinese Medicine,2022,63(22):2135-2140.
袁航,谢立科,罗傑等.前房穿刺联合通窍明目法治疗超过12小时视网膜动脉阻塞气滞血瘀型患者51例临床观察[J].中医杂志,2022,63(22):2135-2140. DOI： 10.13288/j.11-2166/r.2022.22.009.

YUAN Hang,XIE Like,LUO Jie,et al.Clinical Observation on Anterior Chamber Puncture Combined with Orifices-unblocking and Vision-improving Method for the Treatment of Retinal Artery Occlusion for More than 12 Hours with Qi Stagnation and Blood Stasis Syndrome： An analysis of 51 Cases[J].Journal of Traditional Chinese Medicine,2022,63(22):2135-2140. DOI： 10.13288/j.11-2166/r.2022.22.009.

摘要

目的

探讨前房穿刺联合通窍明目法治疗超过12 h视网膜动脉阻塞气滞血瘀证的临床疗效及安全性。

方法

纳入病程超过12 h的视网膜动脉阻塞气滞血瘀证的患者52例（51眼），其中视网膜中央动脉阻塞36眼，视网膜分支动脉阻塞16眼，急行前房穿刺术，后予通窍明目法治疗，包括口服通窍活血明目方、针刺、静脉滴注丹参多酚酸盐注射液联合血栓通注射液、肌肉注射注射用腺苷钴胺，共治疗21天。观察治疗前、穿刺后、治疗7天、治疗21天的最佳矫正视力；比较治疗前与前房穿刺后眼压的变化，并评价临床疗效及安全性，分析年龄、性别、疾病类型、病程与治疗效果的相关性。

结果

52眼中显效23眼（44.2%），好转22眼（42.3%），无效7眼（13.5%），总有效率为86.5%。患者治疗前、穿刺后、治疗7天、治疗21天最佳矫正视力分别为1.80（0.55，2.43）、1.65（0.30，2.18）、1.10（0.20，2.00）、0.85（0.20，1.70）。治疗7天、21天最佳矫正视力较治疗前提高，治疗7天、21天最佳矫正视力较穿刺后提高，治疗21天较治疗7天最佳矫正视力提高（

＜0.01）。治疗前与穿刺后最佳矫正视力差值、眼压差值与治疗有效性间无相关性（

＞0.05）。患者的性别、年龄、疾病分类、病程与治疗有效性间无相关性（

＞0.05）。治疗过程中患者均未出现不良反应。

结论

前房穿刺联合通窍明目法治疗超过12 h视网膜动脉阻塞气滞血瘀证能够提高患者的最佳矫正视力，具有较好的临床疗效及安全性，且不受性别、年龄、疾病类型及病程的影响。

Abstract

Objective

To explore the clinical efficacy and safety of anterior chamber puncture combined with orifices-unblocking and vision-improving method in the treatment of retinal artery occlusion （RAO） for more than 12 hours with

stagnation and blood stasis syndrome.

Methods

Fifty-one patients （52 eyes） with RAO for more than 12 hours and

stagnation and blood stasis syndrome were included， involving 36 eyes of central retinal artery occlusion and 16 eyes of branch retinal artery occlusion. Anterior chamber puncture was performed in emergency. After that， rifices-unblocking and vision-improving treatment was given， including oral

Tongqiao Huoxue Mingmu Formula

（通窍活血明目方）， acupuncture， intravenous drip of salvia polyphenolate injection and

Xueshuantong injection

（血栓通注射液）， and intramuscular injection of adenosylcobalamin， totally for 21 days. The best corrected visual acuity （BCVA） before treatment， after puncture， 7 days after treatment， and 21 days after treatment was measured； the change of the intraocular pressure （IOP） before and after the anterior chamber puncture was evaluated， and the clinical efficacy and safety were assessed. The associations of age， gender， disease type， disease duration with treatment efficacy were analyzed.

Result

After the treatment， 23 eyes （44.2%） were markedly effective， and 22 eyes （42.3%） were improved， while 7 eyes （13.5%） were ineffective， with an overall clinical efficacy of 86.5%. The BCVA before treatment， after anterior chamber puncture， after 7- and 21-day treatment was 1.80 （0.55， 2.43）， 1.65 （0.30， 2.18）， 1.10 （0.20， 2.00）， and 0.85 （0.20， 1.70）， respectively. The BCVA after 7- and 21-day treatment significantly increased compared to that before treatment and that after puncture， and more increase was found with 21-day treatment than 7-day treatment （

＜0.01）. The changes of BCVA and IOA before treatment and after puncture were not significantly correlated to clinical efficacy （

＞0.05）. Sex， gender， disease type， and disease course were not significantly correlated to clinical efficacy （

＞0.05）. There were no adverse reactions in all the patients during the treatment.

Conclusion

Anterior chamber puncture plus orifices-unblocking and vision-improving treatment can improve the BCVA of patients with RAO for more than 12 hours and

stagnation and blood stasis syndrome， with sound clinical efficacy and safety， and is not affected by gender， age， disease type and course.

关键词

Keywords

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Clinical Observation on Anterior Chamber Puncture Combined with Orifices-unblocking and Vision-improving Method for the Treatment of Retinal Artery Occlusion for More than 12 Hours with Qi Stagnation and Blood Stasis Syndrome： An analysis of 51 Cases

DOI：10.13288/j.11-2166/r.2022.22.009

摘要

Abstract

关键词

Keywords

references