Clinical Effect of Adjuvant <italic style="font-style: italic">Huoluo Yinao Formula</italic>（活络益脑方）on White Matter Hyperintensity of Presumed Vascular Origin with Gait Disorder in 52 Cases

HUANG Jingjing; ZHU Xinyi; WANG Yuqing; LI Nannan; CHEN Zhigang

doi:10.13288/j.11-2166/r.2022.23.009

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Clinical Effect of Adjuvant Huoluo Yinao Formula（活络益脑方）on White Matter Hyperintensity of Presumed Vascular Origin with Gait Disorder in 52 Cases

更新时间：2022-11-28

- Clinical Effect of Adjuvant Huoluo Yinao Formula（活络益脑方）on White Matter Hyperintensity of Presumed Vascular Origin with Gait Disorder in 52 Cases
- Journal of Traditional Chinese Medicine Vol. 63, Issue 23, Pages: 2246-2251(2022)
- 作者机构：
  
  1.北京中医药大学第二临床医学院，北京市朝阳区北三环东路11号，100029
  2.上海医大医院
  3.中国中医科学院针灸研究所
  4.北京中医药大学东方医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2022.23.009
  CLC：
- Received：09 May 2022，
  
  Revised：2022-09-25，
  
  Published：02 December 2022
- 稿件说明：
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黄晶晶,朱心怡,王雨晴等.活络益脑方辅助治疗血管源性脑白质高信号伴步态障碍患者52例临床观察[J].中医杂志,2022,63(23):2246-2251.

HUANG Jingjing,ZHU Xinyi,WANG Yuqing,et al.Clinical Effect of Adjuvant Huoluo Yinao Formula（活络益脑方）on White Matter Hyperintensity of Presumed Vascular Origin with Gait Disorder in 52 Cases[J].Journal of Traditional Chinese Medicine,2022,63(23):2246-2251.
黄晶晶,朱心怡,王雨晴等.活络益脑方辅助治疗血管源性脑白质高信号伴步态障碍患者52例临床观察[J].中医杂志,2022,63(23):2246-2251. DOI： 10.13288/j.11-2166/r.2022.23.009.

HUANG Jingjing,ZHU Xinyi,WANG Yuqing,et al.Clinical Effect of Adjuvant Huoluo Yinao Formula（活络益脑方）on White Matter Hyperintensity of Presumed Vascular Origin with Gait Disorder in 52 Cases[J].Journal of Traditional Chinese Medicine,2022,63(23):2246-2251. DOI： 10.13288/j.11-2166/r.2022.23.009.

摘要

目的

观察活络益脑方治疗血管源性脑白质高信号（WMH）伴步态障碍患者的临床疗效。

方法

将90例WMH伴步态障碍患者分为治疗组54例和对照组36例。对照组患者进行基础病的常规治疗（包括口服西药控制血压、血糖、血脂）和运动指导，治疗组在对照组的基础上加用活络益脑方免煎颗粒剂口服，每日1剂。两组疗程均为3个月。治疗前后比较两组单任务步行速度及双任务步行速度，采用Berg平衡量表（BBS）评分、Tinetti 步态和平衡测试量表评分、简易体能状况量表（SPPB）评分评价患者平衡功能和躯体功能。

结果

治疗组患者治疗后SPPB评分、BBS评分、Tinetti步态和平衡测试量表总分、Tinetti步态评分、单任务步行速度及双任务步行速度均较治疗前提高（

＜0.05）。对照组患者治疗后双任务步行速度较治疗前下降（

＜0.05）。两组患者治疗前后差值比较，治疗组SPPB评分、BBS评分、Tinetti步态和平衡测试量表总分、Tinetti平衡评分、Tinetti步态评分、单任务步行速度及双任务步行速度差值与对照组比较差异均具有统计学意义（

＜0.05）。

结论

活络益脑方可有效提高WMH伴步态障碍患者步行速度，可一定程度上改善患者的步态与平衡功能。

Abstract

Objective

To observe the clinical effect of

Huoluo Yinao Formula

（活络益脑方） on white matter hyperintensity of presumed vascular origin （WMH） with gait disorder.

Methods

Ninety patients of WMH with gait disorder were included and divided into treatment group （54 cases） and control group （36 cases）. Routine treatment including oral western medicine to control blood pressure， blood sugar and lipids plus exercise instruction was given to both groups， and granulated

Huoluo Yinao Formula， one dose daily，

was orally administered in addition in the treatment group. The course of treatment in both groups was 3 months. Walking speed under single-/dual-task walking conditions were compared between groups before and after treatment. Berg Balance Scale （BBS）， Tinetti Balance and Gait Assessment， and Short Physical Performance Battery （SPPB） were used to evaluate patients' balance function and physical function.

Results

In the treatment group， the SPPB score， the BBS score， Tinetti total balance and gait score， Tinetti gait score， single-task and dual-task walking speed were improved after treatment （

＜0.05）. In the control group， the dual-task walking speed decreased after treatment （

＜0.05）.As for the changes after treatment， there were significant differences between groups in SPPB score， BBS score， Tinetti total balance and gait score， Tinetti gait score， single-task and dual-task walking speed （

＜0.05）.

Conclusion

Huoluo Yinao Formula

can improve the walking speed effectively， and improve the gait and balance function to some extent for patients with WMH and gait disorder.

关键词

Keywords

references

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Clinical Effect of Adjuvant Huoluo Yinao Formula（活络益脑方）on White Matter Hyperintensity of Presumed Vascular Origin with Gait Disorder in 52 Cases

DOI：10.13288/j.11-2166/r.2022.23.009

摘要

Abstract

关键词

Keywords

references