In view of the complex process of human life and disease， this paper analyzed the disease process based on the pulse manifestations from the perspective of systemic traditional Chinese medicine （TCM）. It is believed that the disease process is a part of the human life system， and should be understood following the seven basic principles of systematic TCM， including non-additive principle， monism and holism principle， adaptation of humans to the natural environment principle， organic relationship principle， functionality principle， orderliness principle， and autonomy principle. It is proposed that disease is an overall disorder in human under the concept of holism， involving many elements such as human and natural environment，

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（脏腑） organs and tissues， the local and the whole， and psychology and body； among them， the hierarchy of each element constitutes the vertical network of the disease process， and the temporality of the hierarchy and the elements constitutes the horizontal relationship. Accordingly， the vertical hierarchy and horizontal temporality two-way framework of disease process can be constructed by analyzing the causation， evolution， parallelism and timing relationships of each element and hierarchy of the pus manifestations.