CAO Luchang,WANG Xinmiao,ZHU Xiaoyu,et al.Exploring the Pathomechanism and Treatment of Cancer-related Insomnia based on the Law of Ying-wei (营卫) Circulation[J].Journal of Traditional Chinese Medicine,2023,64(01):27-31.
CAO Luchang,WANG Xinmiao,ZHU Xiaoyu,et al.Exploring the Pathomechanism and Treatment of Cancer-related Insomnia based on the Law of Ying-wei (营卫) Circulation[J].Journal of Traditional Chinese Medicine,2023,64(01):27-31.DOI: 10.13288/j.11-2166/r.2023.01.006.
Exploring the Pathomechanism and Treatment of Cancer-related Insomnia based on the Law of Ying-wei (营卫) Circulation
Cancer related insomnia (CRI) often occurs in cancer patients, and is related to onset, development and treatment of cancer. CRI has a negative promoting effect on cancer evolution and may become one of the risk factors for cancer development. Based on the law of
ying
-
wei
(营卫) circulation recorded in
Inner Canon of Yellow Emperor
(《黄帝内经》), this paper puts forward the diurnal cycle of “fleshy exterior-muscle surface (pleurodiaphragmatic interspace)” in
ying
-
wei
to explore the mechanism of sleep, and divide the cancer-related insomnia into sleep qua-lity, sleep time, and sleep period abnormalities based on manifestations. The core pathomechanism of difficulty in falling asleep (sleep time abnormality) is loss of the governing in
qi
flow due to liver constraint, which could be treated by softening the liver form and soothing the liver
yin
. Early awakening (sleep time abnormality) is mainly due to deficiency of spleen-
qi
failing to constrain, and can be treated by fortifying the spleen and soothing the liver with appropriate therapy at different time. In terms of sleep quality abnormalities, shallow sleep and easy awakening is mainly due to restless corporeal soul of lung, and the method of nourishing blood and directing lung
qi
downward is suggested; insomnia and dreaminess is mainly caused by phlegm and blood stasis disturbing the heart, and can be treated by unblocking and venting the membrane-source. Sleep stage abnormality is mainly manifested as lack of spirit during the day and sleeplessness at night, with the pathomechanism of kidney-yang deficiency, for which the method of lesser fire generating yang is advised. By discussing the pathomechanism, differentiation and treatment of cancer-related insomnia from the law of
ying
-
wei
circulation, this paper can enrich the theoretical connotation and the clinical treatment ideas of cancer-related insomnia by TCM.
ALMAQBALI M , ALSINANI M , ALSAYED A , et al . Prevalence of sleep disturbance in patients with cancer: a systematic review and meta-analysis [J]. Clin Nurs Res , 2022 , 31 ( 6 ): 1107 - 1123 .
PALESH O , ALDRIDGE-GERRY A , ULUSAKARYA A , et al . Sleep disruption in breast cancer patients and survivors [J]. J Natl Compr Canc Netw , 2013 , 11 ( 12 ): 1523 - 1530 .
BLASK DE . Melatonin, sleep disturbance and cancer risk [J]. Sleep Med Rev , 2008 , 13 ( 4 ): 257 - 264 .
MIASKOWSKI C , LEE K , DUNN L , et al . Sleep-wake circadian activity rhythm para-meters and fatigue in onco-logy patients before the initiation of radiation therapy [J]. Cancer Nurs , 2011 , 34 ( 4 ): 255 - 268 .
GARLAND SN , IRWIN MR , POSNER D , et al . Are sleep continuity disturbance and fatigue prodromal symptoms of cancer development? [J]. Med Hypotheses , 2018 , 120 : 72 - 75 . doi: org/10.1016/j.mehy. 2018. 08.019 http://dx.doi.org/org/10.1016/j.mehy.2018.08.019 .
MAASS SW , ROORDA C , BERENDSEN AJ , et al . The prevalence of long-term symptoms of depression and anxiety after breast cancer treatment: a systematic review [J]. Maturitas , 2015 , 82 ( 1 ): 100 - 108 .
Diagnostic and Therapeutic Strategies for Cancer-Related Insomnia from the Perspective of "Constraint" Based on the Five Viewpoints of Diagnosis and Treatment System
Discussion on Differentiation and Treatment of Food Allergy in Children from the Perspective of Ying-wei (营卫) Theory
Construction and Application of a Real-World Cohort of Community-Acquired Pneumonia Based on a Multimodal Large-Scale Traditional Chinese Medicine Big Data Platform
Research on the Correlation Between "Tiangui (天癸)" and Female Reproductive Genetic Diseases
LI Guolie's Experience in Treating Orthostatic Hypotension from the Perspective of "Raising the Clear and Directing the Turbid Downward"
Related Author
WANG Zilin
GE Yuansha
LI Jie
ZHOU Yao
QIN Wen
LI Yongjun
LIU Lujia
WANG Youpeng
Related Institution
Beijing University of Chinese Medicine
Guang'anmen Hospital,China Academy of Chinese Medical Sciences
Heilongjiang University of Chinese Medicine
Second Affiliated Hospital of Heilongjiang University of Chinese Medicine