Pathogenesis，Differentiation and Treatment of Mild Cognitive Impairment based on the Theory of“Turbid Pathogen Affecting Clearness”

LI Nana; ZHANG Ruiming; SHA Zhongwei; LI Ou; WANG Yuxia; XU Jian

doi:10.13288/j.11-2166/r.2023.04.006

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Pathogenesis，Differentiation and Treatment of Mild Cognitive Impairment based on the Theory of“Turbid Pathogen Affecting Clearness”

更新时间：2023-02-14

- Pathogenesis，Differentiation and Treatment of Mild Cognitive Impairment based on the Theory of“Turbid Pathogen Affecting Clearness”
- Journal of Traditional Chinese Medicine Vol. 64, Issue 4, Pages: 346-349(2023)
- 作者机构：
  
  1.上海中医药大学附属市中医医院，上海市静安区芷江中路274号，200071
  2.山东省临沂市中医医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2023.04.006
  CLC：
- Received：11 July 2022，
  
  Revised：2022-08-04，
  
  Published：17 February 2023
- 稿件说明：
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李娜娜,张芮铭,沙中玮等.基于“浊邪害清”理论探讨轻度认知障碍的病机与辨治[J].中医杂志,2023,64(04):346-349.

LI Nana,ZHANG Ruiming,SHA Zhongwei,et al.Pathogenesis，Differentiation and Treatment of Mild Cognitive Impairment based on the Theory of“Turbid Pathogen Affecting Clearness”[J].Journal of Traditional Chinese Medicine,2023,64(04):346-349.
李娜娜,张芮铭,沙中玮等.基于“浊邪害清”理论探讨轻度认知障碍的病机与辨治[J].中医杂志,2023,64(04):346-349. DOI： 10.13288/j.11-2166/r.2023.04.006.

LI Nana,ZHANG Ruiming,SHA Zhongwei,et al.Pathogenesis，Differentiation and Treatment of Mild Cognitive Impairment based on the Theory of“Turbid Pathogen Affecting Clearness”[J].Journal of Traditional Chinese Medicine,2023,64(04):346-349. DOI： 10.13288/j.11-2166/r.2023.04.006.

摘要

认为“浊邪害清”理论挈合轻度认知障碍的病理特点。结合基础研究与临床实践观察，从多层次阐释轻度认知障碍的病机演变过程，认为“浊邪害清”为其核心病机，提出清气虚衰、精微不化乃轻度认知障碍的发病基础，内生浊邪为病理产物，浊毒内蕴败坏清窍。基于此病机，将补虚化浊作为基本治疗思路，补虚培本、祛除浊邪、升清降浊、解毒通络为核心治法。

Abstract

It is believed that the theory of “turbid pathogen affecting clearness” fits the pathological characteristics of mild cognitive impairment （MCI）. Based on laboratory research and clinical practice， this paper explains the pathogenic evolution of MCI from multiple levels， and takes “turbid pathogen affecting clearness” as the core pathogenesis. It is proposed that the depletion of clear

and the failure to transform into essence is the pathogenic basis of MCI， while internal generated turbid pathogen is the pathological product. When the disease is progressed， turbidity toxin is accumulated in the internal， thereby damaging the clearing orifices. According to this pathogenesis， the basic principle of treatment is supplementing deficiency and removing turbidity， and the core methods of supplementing deficiency and banking up the root， dispelling turbid pathogen， raising the clear and directing the turbid downward， resolving toxins and unblocking collaterals are recommended.

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references

CHEN YX ， LIANG N ， LI XL ， et al . Diagnosis and treatment for mild cognitive impairment： a systematic review of clinical practice guidelines and consensus statements ［J］. Front Neurol ， 2021 ， 12 ： 719849 . doi： 10.3389/fneur. 2021.719849 http://dx.doi.org/10.3389/fneur.2021.719849 .

史路平，姚水洪，王薇 . 中国老年人群轻度认知障碍患病率及发展趋势的Meta分析［J］. 中国全科医学， 2022 ， 25 （ 1 ）： 109 - 114 .

温雅，许永楷，孙美灵，等 . 从“浊邪害清”论“湿热致中” ［J］. 北京中医药大学学报， 2021 ， 44 （ 11 ）： 987 - 991 .

宫润珍 . 浊邪害清浅释［J］. 辽宁中医药大学学报， 2006 ， 8 （ 5 ）： 102 .

何伟 . 构建中医浊邪理论体系框架的初步探讨［J］. 中医杂志， 2015 ， 56 （ 21 ）： 1801 - 1803 .

王晋平，吴林，唐农，等 . 从阴阳本体结构探讨温阳化浊法对养生及抗衰老相关疾病的现实意义［J］. 中国中医基础医学杂志， 2017 ， 23 （ 2 ）： 210 - 212 .

季春林，郭蕾，佟志，等 . 气虚浊留与浊病［J］. 中国医药指南， 2009 ， 7 （ 18 ）： 38 - 39 .

MATTSON MP ， ARUMUGAM TV . Hallmarks of brain aging： adaptive and pathological modification by metabolic states ［J］. Cell Metab ， 2018 ， 27 （ 6 ）： 1176 - 1199 .

BAI T ， YU S ， FENG J . Advances in the role of endothelial cells in cerebral small vessel disease ［J］. Front Neurol ， 2022 ， 13 ： 861714 . doi： 10.3389/fneur. 2022. 861714 http://dx.doi.org/10.3389/fneur.2022.861714 .

LI J ， LI M ， GE Y ， et al . β-amyloid protein induces mitophagy-dependent ferroptosis through the CD36/PINK/PARKIN pathway leading to blood-brain barrier destruction in Alzheimer's disease ［J］. Cell Biosci ， 2022 ， 12 （ 1 ）： 69 .

WANG H ， ZHANG M ， LI J ， et al . Gut microbiota is causally associated with poststroke cognitive impairment through lipopolysaccharide and butyrate ［J］. J Neuroinflammation ， 2022 ， 19 （ 1 ）： 76 .

王永炎 . 关于提高脑血管疾病疗效难点的思考［J］. 中国中西医结合杂志， 1997 ， 17 （ 4 ）： 176 .

DEMPSEY RJ ， VEMUGANTI R ， VARGHESE T ， et al . A review of carotid atherosclerosis and vascular cognitive decline： a new understanding of the keys to symptomogy ［J］. Neurosurgery ， 2010 ， 67 （ 2 ）： 484 - 494 .

杨春，李强，李金波 . 中医药治疗轻度认知障碍临床用药规律分析［J］. 内蒙古中医药， 2018 ， 37 （ 2 ）： 87 - 88 .

侯锡鸿，张佩林，王斯娴，等 . 芳香开窍中药对中枢神经系统疾病的治疗作用研究进展［J］. 药学进展， 2021 ， 45 （ 5 ）： 372 - 381 .

秦中朋，詹向红 . “气郁体质致轻度认知功能障碍”和“疏肝解郁法调体干预气郁质轻度认知功能障碍”的认知心理学研究可行性［J］. 中华中医药学刊， 2021 ， 39 （ 5 ）： 133 - 136 .

刘宇，李斯，刘时乔，等 . 王彦刚教授运用虫类药治疗脾胃病经验采菁［J］. 福建中医药， 2020 ， 51 （ 6 ）： 61 - 63，75 .

李雯斌 . 虫类中药抗动脉粥样硬化的作用机制概述［J］. 浙江中医杂志， 2017 ， 52 （ 2 ）： 154 - 155 .

刘红喜，梁晓，申伟，等 . 升清降浊理论在脑病中的临床运用［J］. 上海中医药杂志， 2022 ， 56 （ 1 ）： 54 - 57，66 .

徐奚如，张彪，张静，等 . 基于数据挖掘的名老中医治疗健忘的用药规律探析［J］. 现代中西医结合杂志， 2020 ， 29 （ 20 ）： 2217 - 2221 .

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