Survey on the Differences in Disease Activity between Kidney Deficiency Obstruction Syndrome and Damp-heat Obstruction Syndrome of Ankylosing Spondylitis Patients

ZHANG Xinlu; LIU Hongxiao; JIANG Quan; FENG Xinghua; WEN Tiancai; XU Xiaohan; MA Xiaoxia; FANG Hui

doi:10.13288/j.11-2166/r.2023.12.009

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Survey on the Differences in Disease Activity between Kidney Deficiency Obstruction Syndrome and Damp-heat Obstruction Syndrome of Ankylosing Spondylitis Patients

更新时间：2023-06-19

- Survey on the Differences in Disease Activity between Kidney Deficiency Obstruction Syndrome and Damp-heat Obstruction Syndrome of Ankylosing Spondylitis Patients
- Journal of Traditional Chinese Medicine Vol. 64, Issue 12, Pages: 1235-1239(2023)
- 作者机构：
  
  1.中国中医科学院广安门医院，北京市西城区北线阁5号，100053
  2.北京中医药大学
  3.中国中医科学院中医药数据中心
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2023.12.009
  CLC：
- Received：18 December 2022，
  
  Revised：2023-04-15，
  
  Published：17 June 2023
- 稿件说明：
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张新路,刘宏潇,姜泉等.强直性脊柱炎肾虚瘀阻证和湿热瘀阻证患者疾病活动度特征差异调查[J].中医杂志,2023,64(12):1235-1239.

ZHANG Xinlu,LIU Hongxiao,JIANG Quan,et al.Survey on the Differences in Disease Activity between Kidney Deficiency Obstruction Syndrome and Damp-heat Obstruction Syndrome of Ankylosing Spondylitis Patients[J].Journal of Traditional Chinese Medicine,2023,64(12):1235-1239.
张新路,刘宏潇,姜泉等.强直性脊柱炎肾虚瘀阻证和湿热瘀阻证患者疾病活动度特征差异调查[J].中医杂志,2023,64(12):1235-1239. DOI： 10.13288/j.11-2166/r.2023.12.009.

ZHANG Xinlu,LIU Hongxiao,JIANG Quan,et al.Survey on the Differences in Disease Activity between Kidney Deficiency Obstruction Syndrome and Damp-heat Obstruction Syndrome of Ankylosing Spondylitis Patients[J].Journal of Traditional Chinese Medicine,2023,64(12):1235-1239. DOI： 10.13288/j.11-2166/r.2023.12.009.

摘要

目的

探讨强直性脊柱炎（AS）肾虚瘀阻证与湿热瘀阻证患者的疾病活动度特征的差异。

方法

制定“强直性脊柱炎证候信息采集量表”，从全国7个中心纳入肾虚瘀阻证与湿热瘀阻证AS患者。观察肾虚瘀阻证与湿热瘀阻证患者AS疾病活动度评分-C反应蛋白（ASDAS-CRP）、AS疾病活动度评分-血沉（ASDAS-ESR）、Bath强直性脊柱炎病情活动指数（BASDAI）评分、患者整体评估（PGA）评分、单一症状（腰背痛、外周关节疼痛/肿胀、晨僵时间、晨僵程度、触痛/压痛和疲乏）评分，检测C反应蛋白（CRP）和红细胞沉降率（ESR）水平。按照ASDAS-CRP评估两组患者疾病活动情况。

结果

纳入强直性脊柱炎肾虚瘀阻证患者684例，湿热瘀阻证患者558例。两组患者PGA评分以及CRP、ESR水平比较，差异均无统计学意义（

＞0.05）。单一症状评分中，腰背痛、外周关节疼痛/肿胀、晨僵时间及触痛/压痛评分，湿热瘀阻证均高于肾虚瘀阻证（

＜0.05或

＜0.01）。湿热瘀阻证患者ASDAS-CRP、ASDAS-ESR及BASDAI评分均高于肾虚瘀阻证患者（

＜0.01）。肾虚瘀阻证患者临床缓解79例（11.55%）、低疾病活动度178例（26.02%）、高疾病活动度338例（49.42%）、极高疾病活动度89例（13.01%）；湿热瘀阻证患者临床缓解53例（9.50%）、低疾病活动度126例（22.58%）、高疾病活动度295例（52.87%）、极高疾病活动度84例（15.05%）；两组患者疾病活动度等级分布差异具有统计学意义（

＜0.05）。

结论

强直性脊柱炎湿热瘀阻证患者的疾病活动度高于肾虚瘀阻证患者，且湿热瘀阻证患者处于高疾病活动及极高疾病活动状态的比例更高。

Abstract

Objective

To compare the characteristics of disease activity between kidney deficiency obstruction syndrome and damp-heat obstruction syndrome in patients with ankylosing spondylitis （AS）.

Methods

A survey was conducted in seven centers nationwide to collect data on AS patients with kidney deficiency obstruction syndrome and damp-heat obstruction syndrome using

Ankylosing Spondylitis Syndrome Information Collection Scale

. The AS di-sease activity score with C-reactive protein （ASDAS-CRP）， AS disease activity score-erythrocyte sedimentation rate （ASDAS-ESR）， Bath ankylosing spondylitis disease activity index （BASDAI） score， patient global assessment （PGA） score， single symptom （low back pain， peripheral joint pain/swelling， duration of morning stiffness， degree of morning stiffness， tenderness/pressing pain and fatigue） scores， C-reactive protein （CRP） and erythrocyte sedimentation rate （ESR） levels were assessed in the two groups. The disease activity of patients in the two groups was evaluated according to ASDAS-CRP.

Results

Totally， 684 AS patients with kidney deficiency obstruction syndrome and 558 AS patients with damp-heat obstruction syndrome were included. There was no significant difference in PGA score， CRP and ESR levels between the two groups （

＞0.05）. In terms of the single symptom， the scores of low back pain， peripheral joint pain/swelling， duration of morning stiffness and tenderness/pressing pain were higher in damp-heat obstruction syndrome patients than in kidney deficiency obstruction syndrome patients （

＜0.05 or

＜0.01）. The ASDAS-CRP， ASDAS-ESR and BASDAI scores were much higher in patients with damp-heat obstruction syndrome （

＜0.01）. There were 79 （11.55%） clinical remission cases， 178 （26.02%） low disease activity cases， 338 （49.42%） high disease activity cases， and 89 （13.01%） very high disease activity cases in patients with kidney deficiency obstruction syndrome， while the proportion was 53 （9.50%）， 126 （22.58%）， 295 （52.87%） and 84 （15.05%） in patients with damp-heat obstruction syndrome， with significantly differences in the distribution of disease activity levels between groups （

＜0.05）.

Conclusion

AS patients with damp-heat obstruction syndrome have higher disease activity and higher proportion of high and very high disease activity status than those with kidney deficiency obstruction syndrome.

关键词

Keywords

references

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