Contribution of Traditional Chinese Medicine Combined with Conventional Medicine Treatment for a Long-Term Survivor of Heart Transplant with Severe COVID-19： A Case Report

XUE Chongxiang; ZHANG Yanjiao; CHEN Ying; ZHOU Dannini; WANG Bing; SUN Jun; ZHOU Ling; TIAN Chuanxi; ZHAO Xuefei; CHENG Jinbo; LI Xiuyang; XIAO Dong

doi:10.13288/j.11-2166/r.2023.22.016

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Contribution of Traditional Chinese Medicine Combined with Conventional Medicine Treatment for a Long-Term Survivor of Heart Transplant with Severe COVID-19： A Case Report

更新时间：2023-11-10

- Contribution of Traditional Chinese Medicine Combined with Conventional Medicine Treatment for a Long-Term Survivor of Heart Transplant with Severe COVID-19： A Case Report
  增强出版
- Journal of Traditional Chinese Medicine Vol. 64, Issue 22, Pages: 2359-2362(2023)
- 作者机构：
  
  1.北京中医药大学，北京市朝阳区北三环东路11号，100029
  2.中国中医科学院广安门医院
  3.甘肃中医药大学
  4.新疆医科大学附属中医医院
  5.长春中医药大学附属医院
  6.陆军军医大学附属第二医院
  7.新疆维吾尔自治区人民医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2023.22.016
  CLC：
- Received：25 March 2023，
  
  Revised：2023-06-26，
  
  Published：17 November 2023
- 稿件说明：
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薛崇祥,张艳娇,陈颖等.中西医结合治疗长期生存心脏移植患者合并新型冠状病毒感染（重型）1例[J].中医杂志,2023,64(22):2359-2362.

XUE Chongxiang,ZHANG Yanjiao,CHEN Ying,et al.Contribution of Traditional Chinese Medicine Combined with Conventional Medicine Treatment for a Long-Term Survivor of Heart Transplant with Severe COVID-19： A Case Report[J].Journal of Traditional Chinese Medicine,2023,64(22):2359-2362.
薛崇祥,张艳娇,陈颖等.中西医结合治疗长期生存心脏移植患者合并新型冠状病毒感染（重型）1例[J].中医杂志,2023,64(22):2359-2362. DOI： 10.13288/j.11-2166/r.2023.22.016.

XUE Chongxiang,ZHANG Yanjiao,CHEN Ying,et al.Contribution of Traditional Chinese Medicine Combined with Conventional Medicine Treatment for a Long-Term Survivor of Heart Transplant with Severe COVID-19： A Case Report[J].Journal of Traditional Chinese Medicine,2023,64(22):2359-2362. DOI： 10.13288/j.11-2166/r.2023.22.016.

摘要

报告1例长期生存心脏移植患者合并新型冠状病毒感染（重型）的中西医结合治疗过程。患者治疗中始终予西医积极对症治疗，中医药治疗历经益气补中、健脾化痰，通阳散结、祛湿化痰、活血化瘀，最终以回阳救逆、化痰利水、活血通络为主要治则，予破格子龙宣白承气汤加减收功。总结治疗经验，免疫抗排斥方案的及时调整、以抗新型冠状病毒为主导的多种抗感染药物联合运用、心肾功能保护以及中医药的联合使用，在整个治疗过程中发挥了重要作用。因病例罕见，其中医辨证诊治及中医药使用、免疫抑制剂的启动时机及后续监测思路值得借鉴。

Abstract

We report a case of a long-term survivor of heart transplant who developed severe COVID-19 and was treated with a traditional Chinese medicine combined with conventional medicine. Throughout the treatment， the patient received active conventional medical treatment， and traditional Chinese medicine interventions included tonifying

， invigorating the spleen and transforming phlegm， promoting

yang

and eliminating stagnation， resolving dampness and dissipating phlegm， and promoting blood circulation and eliminating stasis. The main therapeutic principles adopted were to recuperating depleted

yang

and rescuing the patient from collapse and to resolve phlegm and promote water.

Pogezilong Xuanbai Chengqi Decoction

（破格子龙宣白承气汤） with modifications was administered. In summary， it is crucial to the timely adjust the immunosuppressive regimen， combine use of various anti-infective agents with a focus on COVID-19， to protect of cardiac and renal function， and to integrate traditional Chinese medicine in the entire treatment process. As this case is rare， the diagnostic and therapeutic methods in traditional Chinese medicine， the use of immunosuppressive agents， and follow-up monitoring strategies can be a valuable reference.

关键词

Keywords

references

KHUSH KK ， CHERIKH WS ， CHAMBERS DC ， et al . The international thoracic organ transplant registry of the international society for heart and lung transplantation： thirty-sixth adult heart transplantation report-2019； focus theme： donor and recipient size match ［J］. J Heart Lung Transplant ， 2019 ， 38 （ 10 ）： 1056 - 1066 .

RAJA MA ， MENDOZA MA ， VILLAVICENCIO A ， et al . COVID-19 in solid organ transplant recipients： a systematic review and meta-analysis of current literature ［J］. Transplant Rev （Orlando）， 2021 ， 35 （ 1 ）： 100588 . doi： 10. 1016/j.trre.2020.100588 http://dx.doi.org/10.1016/j.trre.2020.100588 .

AZZI Y ， BARTASH R ， SCALEA J ， et al . COVID-19 and solid organ transplantation： a review article ［J］. Transplantation ， 2021 ， 105 （ 1 ）： 37 - 55 .

RIVINIUS R ， KAYA Z ， SCHRAMM R ， et al . COVID-19 among heart transplant recipients in Germany： a multicenter survey ［J］. Clin Res Cardiol ， 2020 ， 109 （ 12 ）： 1531 - 1539 .

IMMOHR MB ， BALLAZS C ， HETTLICH V ， et al . Heart transplantation in the era of corona virus disease 2019： impact of the pandemic on donors， recipients and outcome ［J］. Clin Transplant ， 2023 ： e14887 . doi： 10.1111/ctr. 14887 http://dx.doi.org/10.1111/ctr.14887 .

SANDOVAL Y ， JANUZZI JL ， JAFFE AS . Cardiac troponin for assessment of myocardial Injury in COVID-19： JACC review topic of the week ［J］. J Am Coll Cardiol ， 2020 ， 76 （ 10 ）： 1244 - 1258 .

CHEN G ， WU D ， GUO W ， et al . Clinical and immunological features of severe and moderate coronavirus disease 2019 ［J］. J Clin Invest ， 2020 ， 130 （ 5 ）： 2620 - 2629 .

仝小林，李修洋，赵林华，等 . 从“寒湿疫”角度探讨新型冠状病毒肺炎的中医药防治策略［J］. 中医杂志， 2020 ， 61 （ 6 ）： 465 - 470，553 .

王文洁，王敏，王蕾，等 . 运用态靶辨治理论治疗特发性间质性肺病经验［J］. 中医杂志， 2022 ， 63 （ 22 ）： 2110 - 2113 .

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