By summarising Professor WANG Xianbo's clinical experience in treating hepatitis B virus associated acute-on-chronic liver failure （HBV-ACLF）， it is believed that HBV-ACLF is a syndrome of root-cause deficiency and manifestation excess， with spleen deficiency as the root cause and dampness-heat-toxicity-blood stasis as the manifestation， and the therapeutic methods proposed as “detoxification and cooling of the blood to promote circulation of the internal organs， and strengthening spleen and resolving dampness to take care of the middle energizer”. In the treatment of HBV-ACLF， for syndrome of stasis-heat-toxicity mass， it was common to use the

Jiedu Liangxue Formula

（解毒凉血方） by detoxifying and cooling blood； For syndrome of dampness-heat-toxicity mass， it was common to use in the

Jiedu Liangxue Lishi Formula

（解毒凉血利湿方） by detoxifying and cooling the blood， strengthening the spleen and resolving dampness； For syndrome of spleen-deficiency and dampness-heat， it was common to use in the

Jiedu Liangxue Jianpi Formula

（解毒凉血健脾方， also known as

Zhonggan No.2 Formula

） by strengthening the spleen and reple-nishing

qi

， clearing heat and resolving dampness.