To summarize Professor TU Jinwen's clinical experience in the treatment of severe influenza based on the “heat toxin theory”. He believed that “heat toxin” is the main disease mechanism of severe influenza， emphasized the pathogenesis process that toxin enters with the pathogenic

qi

， heat generates by the toxin， and changes initiate from the toxin， and proposed simultaneous treatment of warmth and toxin and combination of multiple methods as the treatment principles. Syndrome differentiation in clinic should combine with

wei

-

qi

-

ying

-blood. The disease in the early stage located in

wei

（defensive） and

qi

level， treated by clearing heat and resolving toxins， releasing the exterior and expelling pathogen， harmonizing the exterior and interior， dredging the bowels with diarrhea， and combining other methods to get rid of the heat and toxin， and modified

Self

-

Prescribed Tuire No. 1 Formula

（自拟退热1号方） is recommended； the disease in progression stage located in

ying

-blood， treated by relieving heat and resolving toxins， and clearing the

ying

level and cool the blood， with prescriptions as modified

Self

-

Prescribed Tuire No. 1 Formula

plus

Qingying Decoction

（清营汤）， or

Xijiao Dihuang Decoction

（犀角地黄汤）； the disease in the late stage with of

yin

fluid consumption， and heat toxin in the blood level， treated by eliminating heat and resolving toxins， and enriching

yin

and cooling the blood， with prescriptions as modified

Shashen Maidong Decoction

（沙参麦冬汤） and

Zhuye Shigao Decoction

（竹叶石膏汤）. At the same time， it is emphasised that heat-clearing and fire-draining method and harmonising methods are important， and that dispelling pathogen should not injure healthy

qi

， and that the selection of prescriptions and medicines need consider syndrome differentiation and treatment.