Exploring the Comorbidity Mechanisms of Coronary Heart Disease and Depression Based on "Constraint Causing Disease" and "Disease Causing Constraint" Theories

HAN Huiying; LIU Zhaihua; ZHANG Huamin; CAO Hongxin

doi:10.13288/j.11-2166/r.2024.08.014

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Exploring the Comorbidity Mechanisms of Coronary Heart Disease and Depression Based on "Constraint Causing Disease" and "Disease Causing Constraint" Theories

更新时间：2024-04-11

- Exploring the Comorbidity Mechanisms of Coronary Heart Disease and Depression Based on "Constraint Causing Disease" and "Disease Causing Constraint" Theories
- Journal of Traditional Chinese Medicine Vol. 65, Issue 8, Pages: 858-861(2024)
- 作者机构：
  
  中国中医科学院中医基础理论研究所，北京市东直门内南小街16号，100700
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2024.08.014
  CLC：
- Received：08 September 2023，
  
  Revised：2023-11-22，
  
  Published：17 April 2024
- 稿件说明：
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韩慧莹,刘寨华,张华敏等.基于“因郁致病”“因病致郁”探讨冠心病与抑郁症的共病机理[J].中医杂志,2024,65(08):858-861.

HAN Huiying,LIU Zhaihua,ZHANG Huamin,et al.Exploring the Comorbidity Mechanisms of Coronary Heart Disease and Depression Based on "Constraint Causing Disease" and "Disease Causing Constraint" Theories[J].Journal of Traditional Chinese Medicine,2024,65(08):858-861.
韩慧莹,刘寨华,张华敏等.基于“因郁致病”“因病致郁”探讨冠心病与抑郁症的共病机理[J].中医杂志,2024,65(08):858-861. DOI： 10.13288/j.11-2166/r.2024.08.014.

HAN Huiying,LIU Zhaihua,ZHANG Huamin,et al.Exploring the Comorbidity Mechanisms of Coronary Heart Disease and Depression Based on "Constraint Causing Disease" and "Disease Causing Constraint" Theories[J].Journal of Traditional Chinese Medicine,2024,65(08):858-861. DOI： 10.13288/j.11-2166/r.2024.08.014.

摘要

从“因郁致病”“因病致郁”角度探析冠心病与抑郁症的共病机制，认为“因郁致病”与“因病致郁”之间的纽带是“郁”，气机阻滞是关键。中医学的心藏象涵盖了循环系统、精神神经系统的多数生理过程及部分内分泌系统功能，心脑血管疾病和心理疾病与心藏象密切相关。基于中医学认识提出，心阳郁阻导致“阳微”是冠心病即中医学胸痹的病机所在，情志拂郁导致阳气结聚不得发越则胸痹加重，反映了“因病致郁”过程；随着疾病发展，出现痰、瘀病邪，可进一步加重病情，反映了“因郁致病”过程。基于现代医学认识提出脂质、血小板、氧化产物、细胞因子等的异常聚集即“郁”的一种形式，也是冠心病与抑郁症双心共病的物质基础，这些物质促使情绪和认知区域的神经元损伤或凋亡，诱导抑郁症的发病，反映了“因病致郁”过程；而不良情绪导致交感神经兴奋，产生儿茶酚胺，促进血小板聚集，炎症标志物水平升高，增加了冠心病的致病风险，反映了“因病致郁”过程。

Abstract

This study explored the comorbidity mechanisms of coronary heart disease and depression from the perspectives of "constraint causing disease" and "disease causing constraint"， for which "constraint" is the link， and the key lies in the stagnation of

. The heart storing manifestations in traditional Chinese medicine （TCM） encompasses most physiological processes of the circulatory system， the mental nervous system， and some functions of the endocrine system， and cardiovascular diseases and psychological disorders are closely related to it. In TCM， it is proposed that the stagnation of heart

yang

leading to "

yang

deficiency" is the pathogenesis of chest tightness， and emotional disturbance leading to the stagnation of

yang

aggravates the chest tightness， reflecting the process of "disease causing constraint". As the disease progresses， the appearance of phlegm and stasis further worsens the condition， reflecting the process of "constraint causing disease". Based on modern medical understanding， the abnormal accumulation of lipids， platelets， oxidative products， cytokines， and other substances constitute a form of "constraint"， which is also the material basis for the comorbidity of coronary heart disease and depression. These substances promote neuronal damage or apoptosis in the emotional and cognitive regions， inducing the onset of depression， reflecting the process of "disease causing constraint". Meanwhile， adverse emotions lead to sympathetic nerve excitement， resulting in the production of catecholamines， promoting platelet aggregation， elevating levels of inflammatory markers， and increasing the risk of coronary heart disease， reflecting the process of "disease causing constraint".

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references

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