

浏览全部资源
扫码关注微信
成都中医药大学,四川省成都市温江区柳台大道1166号,611137
Received:20 November 2023,
Revised:2024-02-20,
Published:17 May 2024
移动端阅览
孙佳琦,蒋璐霞,于正等.从表型组学探讨经络稳态动态映射模型[J].中医杂志,2024,65(10):990-995.
SUN Jiaqi,JIANG Luxia,YU Zheng,et al.Construction of Meridian and Collateral Homeostasis Model from Phenomics[J].Journal of Traditional Chinese Medicine,2024,65(10):990-995.
孙佳琦,蒋璐霞,于正等.从表型组学探讨经络稳态动态映射模型[J].中医杂志,2024,65(10):990-995. DOI: 10.13288/j.11-2166/r.2024.10.002.
SUN Jiaqi,JIANG Luxia,YU Zheng,et al.Construction of Meridian and Collateral Homeostasis Model from Phenomics[J].Journal of Traditional Chinese Medicine,2024,65(10):990-995. DOI: 10.13288/j.11-2166/r.2024.10.002.
将“稳态”应用于经络系统的研究,提出经络系统保持平衡、平稳的状态为经络稳态。经络稳态对维持机体健康具有重要作用,可为疾病的诊断和治疗提供参考。表型组学实现了从基因组、蛋白组、代谢组等微观表型数据到生理状态、行为活动、外在表现等宏观表型数据的跨尺度关联。从表型组学的研究角度出发,提出“宏观征象-微观表达”的经络稳态动态映射模型,将中医四诊等宏观征象、穴位的生物物理指标以及基因、蛋白和代谢等微观表达信息结合,系统性地探究经络稳态与健康和疾病的关系,为中医未病状态识别以及精准化诊疗提供思路和参考。
By applying "homeostasis" to the study of the meridian and collateral system, the concept of meridian and collateral homeostasis has been proposed which refers to a balanced and stable state of meridian and collateral system, and plays an important role in maintaining body health and can provide a reference for the diagnosis and treatment of diseases. Phenomics realizes the cross-scale correlation from micro-phenotypic data, such as genome, proteome, and metabolome, to macro-phenotypic data, such as physiological state, behavioral activities, and external manifestations. From the perspective of phenomics, this paper proposes a meridian and collateral homeostasis dynamic mapping model of "macroscopic signs and microscopic expression". This model combines macro signs such as the four examinations of traditional Chinese medicine (TCM), biophysical indicators of acupoints, and micro expression information such as genes, proteins, and metabolism, and systematically investigates the relationship between meridian and collateral homeostasis and health and disease, thereby providing ideas and references for the identification of pre-disease states as well as precise diagnosis and treatment in TCM.
CANNON WB . Organization for physiological homeostasis [J]. Physiol Rev , 1929 , 9 ( 3 ): 399 - 574 .
ZHOU W , BENHARASH P . Effects and mechanisms of acupuncture based on the principle of meridians [J]. J Acupunct Meridian Stud , 2014 , 7 ( 4 ): 190 - 193 .
YE X , REN Y , CHEN Y , et al . A "4D" systemic view on meridian essence: substantial, functional, chronological and cultural attributes [J]. J Integr Med , 2022 , 20 ( 2 ): 96 - 103 .
仝小林 , 何莉莎 , 赵林华 . 助力精准医学:表型组学与中医学的借鉴与融合 [J]. 中国中西医结合杂志 , 2018 , 38 ( 3 ): 368 - 370 .
祝世讷 . 经络的结构是“超解剖”的功能性结构 [J]. 山东中医药大学学报 , 1997 , 21 ( 1 ): 3 - 7,81 .
宁容容 , 刘明 , 丁小姣 , 等 . 基于《黄帝内经》浅谈经络平衡与失衡在疾病方面的应用 [J]. 时珍国医国药 , 2022 , 33 ( 11 ): 2712 - 2714 .
臧云彩 , 谢秋利 , 刘江涛 , 等 . 基于洛书“圆平衡”之象探讨“巨刺”和“缪刺”的理论基础及应用 [J]. 河南中医 , 2023 , 43 ( 8 ): 1156 - 1160 .
CHANG S . The meridian system and mechanism of acupuncture:a comparative review. Part 1: the meridian system [J]. Taiwan J Obstet Gynecol , 2012 , 51 ( 4 ): 506 - 514 .
CHANG S . The meridian system and mechanism of acupuncture:a comparative review. Part 2: mechanism of acupuncture analgesia [J]. Taiwan J Obstet Gynecol , 2013 , 52 ( 1 ): 14 - 24 .
LU WA , TSUEI JJ , CHEN KG . Preferential direction and symmetry of electric conduction of human meridians. Bilaterally symmetrical acupoints provide better conductance for a better "connection" [J]. IEEE Eng Med Biol Mag , 1999 , 18 ( 1 ): 76 - 78 .
赵朋娜 , 王燕平 , 古菲菲 , 等 . 健康人十二经原穴血流量失衡度的初步观察 [J]. 针刺研究 , 2017 , 42 ( 5 ): 439 - 443 .
张舟南 . 人体十二经原穴的太赫兹波特征与经络平衡的相关性研究 [D]. 南昌 : 江西中医药大学 , 2021 .
ZHANG WB , TIAN YY , ZHU ZX , et al . The distribution of transcutaneous CO 2 emission and correlation with the points along the pericardium meridian [J]. J Acupunct Meridian Stud , 2009 , 2 ( 3 ): 197 - 201 .
韩兆亮 . 人体双侧对称经络电阻抗失衡与疾病的相关研究 [J]. 中国医学物理学杂志 , 1999 , 16 ( 2 ): 49 - 51 .
徐冬梅 , 曹立民 , 袁刚 , 等 . 心经穴阻抗值对冠心病的诊断价值 [J]. 山东医药 , 2012 , 52 ( 37 ): 51 - 52 .
WANG X , ZUO G , LIU J , et al . Skin temperature of acupoints in health and primary dysmenorrhea patients: a systematic review and meta-analysis [J]. Pain Res , 2023 , 16 : 2027 - 2046 . doi: 10.2147/JPR.S411923 http://dx.doi.org/10.2147/JPR.S411923 .
SHE YY , MA LX , ZHU J , et al . Comparative study on skin temperature response to menstruation at acupuncture points in healthy volunteers and primary dysmenorrhea patients [J]. J Tradit Chin Med , 2017 , 37 ( 2 ): 220 - 228 .
赵朋娜 , 古菲菲 , 李朝政 , 等 . 健康人十二经原穴经皮二氧化碳释放率失衡度的初步观察 [J]. 世界中医药 , 2022 , 17 ( 18 ): 2640 - 2645 .
古菲菲 , 赵朋娜 , 李朝政 , 等 . 健康人十二经细胞外液阻抗失衡度的初步观察 [J]. 中国针灸 , 2020 , 40 ( 1 ): 43 - 47 .
HOULE D , GOVINDARAJU DR , OMHOLT S . Pheno-mics: the next challenge [J]. Nat Rev Genet , 2010 , 11 ( 12 ): 855 - 866 .
YUAN C , ZHANG W , WANG J , et al . Chinese medicine phenomics (Chinmedphenomics): personalized, precise and promising [J]. Phenomics , 2022 , 2 ( 6 ): 383 - 388 .
彭印高 . 遗传病与相关表达条件:经络与遗传的关系 [J]. 上海针灸杂志 , 2007 , 26 ( 10 ): 25 - 27 .
LEE TN . Thalamic neuron theory: meridians=DNA. The genetic and embryological basis of traditional Chinese medicine including acupuncture [J]. Med Hypotheses , 2002 , 59 ( 5 ): 504 - 521 .
黄应秋 . 遗传性状表达调控网:经络 [J]. 当代医学(学术版) , 2008 , 14 ( 19 ): 161 - 163 .
CHEN C , ZHANG D , HAZBUN TR , et al . Inferring gene regulatory networks from a population of yeast segregants [J]. Sci Rep , 2019 , 9 ( 1 ): 1197 .
GUO ZL , LONGHURST JC . Expression of c-Fos in arcuate nucleus induced by electroacupuncture: relations to neurons containing opioids and glutamate [J]. Brain Res , 2007 , 1166 : 65 - 76 . doi: 10.1016/j.brainres. 2007. 06.042 http://dx.doi.org/10.1016/j.brainres.2007.06.042 .
ZHANG RX , LI A , LIU B , et al . Electroacupuncture atte-nuates bone cancer pain and inhibits spinal interleukin-1β expression in a rat model [J]. Anesth Analg , 2007 , 105 ( 5 ): 1482 - 1488 .
SHIUE HS , LEE YS , TSAI CN , et al . DNA microarray analysis of the effect on inflammation in patients treated with acupuncture for allergic rhinitis [J]. J Altern Complement Med , 2008 , 51 ( 4 ): 53 - 54 .
金翊思 , 袁波 . 微管相关蛋白-2表达的变化对海马梗死大鼠学习记忆能力的影响研究 [J]. 中国实验诊断学 , 2014 , 18 ( 4 ): 538 - 541 .
李秀芳 , 马学红 , 周蓉 , 等 . 针刺改善Ⅱ型胶原蛋白诱导性关节炎大鼠炎性反应的机制研究 [J]. 针刺研究 , 2023 , 48 ( 11 ): 1103 - 1110 .
刘一 , 周梦荻 , 郑宇琦 , 等 . 针刺调控偏头痛大鼠三叉神经脊束核中星形胶质细胞缝隙连接蛋白43抑制干扰素-γ的抗炎镇痛机制 [J]. 针刺研究 , 2023 , 48 ( 2 ): 118 - 124 .
BENIAS PC , WELLS RG , SACKEY-ABOAGYE B , et al . Structure and distribution of an unrecognized interstitium in human tissues [J]. Sci Rep , 2018 , 8 ( 1 ): 4947 .
周立华 , 卢依平 . “经络蛋白能带结构”假说 [J]. 河南中医学院学报 , 2003 , 18 ( 5 ): 13 - 15 .
周立华 , 赵君玫 , 李青雅 , 等 . 大鼠足阳明胃经循经部位发现特异蛋白电泳条带的实验研究 [J]. 河南中医学院学报 , 2006 , 21 ( 6 ): 14 - 15 .
MA SX . Enhanced nitric oxide concentrations and expression of nitric oxide synthase in acupuncture points/meridians [J]. J Altern Complement Med , 2003 , 9 ( 2 ): 207 - 215 .
XU YD , WANG Y , PARK GH , et al . Non-specific physiological background effects of acupuncture revealed by proteomic analysis in normal rats [J]. BMC Complement Altern Med , 2014 , 14 : 375 . doi: 10.1186/1472-6882-14-375 http://dx.doi.org/10.1186/1472-6882-14-375 .
QI Q , ZHONG R , LIU YN , et al . Mechanism of electroacupuncture and herb-partitioned moxibustion on ulce-rative colitis animal model: a study based on proteomics [J]. World J Gastroenterol , 2022 , 28 ( 28 ): 3644 - 3665 .
KEUN KC , SUN CG , DUK OS , et al . Electroacupuncture up-regulates natural killer cell activity: identification of genes altering their expressions in electroacupuncture induced up-regulation of natural killer cell activity [J]. J Neuroimmunol , 2005 , 168 ( 1/2 ): 144 - 153 .
DING X , YU J , YU T , et al . Acupuncture regulates the aging-related changes in gene profile expression of the hippocampus in senescence-accelerated mouse (SAMP10) [J]. Neurosci Lett , 2006 , 399 ( 1/2 ): 11 - 16 .
罗本华 , 赵岚 , 张雪竹 , 等 . 老年性痴呆皮层海马G蛋白表达量、偶联活性及相互作用分子与针刺干预研究 [C]//中国中西医结合学会时间生物医学专业委员会. 2011年全国时间生物医学学术会议论文集 . 南宁 : 中国中西医结合学会 , 2011 : 3 .
LIU J , PENG R , TAN Q , et al . Proteomic analysis of rat colonic mucosa following acupuncture treatment for irritable bowel syndrome with diarrhea [J]. PLoS One , 2022 , 17 ( 9 ): e0273853 .
BAUERMEISTER A , MANNOCHIO-RUSSO H , COSTA-LOTUFO LV , et al . Mass spectrometry-based metabolomics in microbiome investigations [J]. Nat Rev Microbiol , 2022 , 20 ( 3 ): 143 - 160 .
YANG H , LAU WB , LAU B , et al . A mass spectrometric insight into the origins of benign gynecological disorders [J]. Mass Spectrom Rev , 2017 , 36 ( 3 ): 450 - 470 .
杜娟 , 周立华 . 浅论循经部位高能量代谢的形成机制 [J]. 中国针灸 , 2014 , 34 ( 11 ): 1119 - 1121 .
承焕生 , 何文权 , 陈尔瑜 , 等 . 用PIXE研究经络穴位元素浓度的异常分布 [J]. 核技术 , 1999 , 22 ( 8 ): 494 - 499 .
ZHANG D , DING G , SHEN X , et al . Role of mast cells in acupuncture effect: a pilot study [J]. Explore , 2008 , 4 ( 3 ): 170 - 177 .
陈铭 , 胡翔龙 , 吴祖星 . 针刺时督脉线下深部组织中氧分压变化的实验观察 [J]. 针刺研究 , 2008 , 33 ( 6 ): 402 - 405 .
HONG M , PARK SS , HA Y , et al . Heterogeneity of skin surface oxygen level of wrist in relation to acupuncture point [J]. Evid Based Complement Alternat Med , 2012 , 2012 : 106762 . doi: 10.1155/2012/106762 http://dx.doi.org/10.1155/2012/106762 .
EŐRY A . In-vivo skin respiration (CO 2 ) measurements in the acupuncture loci [J]. Acupunct Electrother Res , 1984 , 9 ( 4 ): 217 - 223 .
屈箫箫 . 面部穴位温度和血流灌注对称性及针灸对其调整作用 [D]. 北京 : 中国中医科学院 , 2009 .
OMURA Y . Connections found between each meridian (heart, stomach, triple burner, etc.) & organ representation area of corresponding internal organs in each side of the cerebral cortex; release of common neurotransmitters and hormones unique to each meridian and corresponding acupuncture point & internal organ after acupuncture, electrical stimulation, mechanical stimulation (including shiatsu), soft laser stimulation or QI Gong [J]. Acupunct Electrother Res , 1989 , 14 ( 2 ): 155 - 186 .
谢远军 , 胡翔龙 , 吴宝华 . 经脉循行线上组织氧分压的观察及其针刺的影响 [J]. 中国中医药科技 , 2000 , 7 ( 6 ): 353 - 354,351 .
许小洋 , 胡翔龙 , 吴宝华 . 循经施加机械压力对大肠经三个部位深部组织中氧分压的影响 [J]. 针刺研究 , 2000 , 25 ( 4 ): 276 - 279 .
高凌云 , 胡翔龙 , 许小洋 , 等 . 督脉循行线下深部组织温度的检测 [J]. 针刺研究 , 2006 , 31 ( 3 ): 159 - 162 .
靳聪妮 , 胡翔龙 , 陈铭 . 心包经前臂段经脉线下深部组织温度的测定 [J]. 世界科学技术-中医药现代化 , 2007 , 9 ( 4 ): 26 - 30 .
JUNG J , LEE SM , LEE MJ , et al . Lipidomics reveals that acupuncture modulates the lipid metabolism and inflammatory interaction in a mouse model of depression [J]. Brain Behav Immun , 2021 , 94 : 424 - 436 . doi: 10. 1016/j.bbi.2021.02.003 http://dx.doi.org/10.1016/j.bbi.2021.02.003 .
SHI H , LIU Y , CUI E , et al . A key node mining method based on acupoint-disease network (ADN): a new perspective for exploring acupoint specificity [J]. Evid Based Complement Alternat Med , 2020 , 2020 : 6031601 . doi: 10.1155/2020/6031601 http://dx.doi.org/10.1155/2020/6031601 .
SARKAR S , SINHA SK , LEVINE H , et al . Anticipating critical transitions in epithelial-hybrid-mesenchymal cell-fate determination [J]. Proc Natl Acad Sci U S A , 2019 , 116 ( 52 ): 26343 - 26352 .
ZHANG Y , ZHANG A , YAN G , et al . High-throughput metabolomic approach revealed the acupuncture exerting intervention effects by perturbed signatures and pathways [J]. Mol Biosyst , 2013 , 10 ( 1 ): 65 - 73 .
YAN G , ZHANG A , SUN H , et al . Dissection of biological property of Chinese acupuncture point Zusanli based on long-term treatment via modulating multiple metabolic pathways [J]. Evid Based Complement Alternat Med , 2013 , 2013 : 429703 . doi: 10.1155/2013/429703 http://dx.doi.org/10.1155/2013/429703 .
余曙光 , 唐勇 , 尹海燕 , 等 . 艾灸刺激穴位局部感受的生物学基础 [J]. 世界中医药 , 2013 , 8 ( 8 ): 867 - 870 .
蒋一璐 . 不同敏化状态下KOA模型大鼠敏化穴位组织miRNA的表达差异研究 [D]. 成都 : 成都中医药大学 , 2020 .
JIE B , ZHANG D , CHENG B , et al . Manifold regula-rized multitask feature learning for multimodality disease classification [J]. Hum Brain Mapp , 2015 : 489 - 507 . doi: 10.1002/hbm.22642 http://dx.doi.org/10.1002/hbm.22642 .
0
Views
0
下载量
2
CSCD
Publicity Resources
Related Articles
Related Author
Related Institution
京公网安备11010102007558号