Characteristics of Basal Sex Hormone Levels and Anti-müllerian Hormone Levels in 1221 Women of Different Ages：A Retrospective Study on the Law of Women Reproductive Aging in the "Seven-year Period" Theory

LIANG Wanshi; LIAO Yiru; FU Jinghan; HU Luodan; YANG Hongyan; LIU Jian; CHENG Fangping; NIE Guangning

doi:10.13288/j.11-2166/r.2024.13.011

您当前的位置：

首页 >

文章列表页 >

Characteristics of Basal Sex Hormone Levels and Anti-müllerian Hormone Levels in 1221 Women of Different Ages：A Retrospective Study on the Law of Women Reproductive Aging in the "Seven-year Period" Theory

更新时间：2024-06-28

- Characteristics of Basal Sex Hormone Levels and Anti-müllerian Hormone Levels in 1221 Women of Different Ages：A Retrospective Study on the Law of Women Reproductive Aging in the "Seven-year Period" Theory
- Journal of Traditional Chinese Medicine Vol. 65, Issue 13, Pages: 1369-1374(2024)
- 作者机构：
  
  1.广州中医药大学第二临床医学院，广东省广州市白云区机场路12号，510405
  2.河南中医药大学中医学院仲景书院
  3.广州中医药大学第二附属医院/广东省中医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2024.13.011
  CLC：
- Received：20 November 2023，
  
  Revised：2024-03-29，
  
  Published：02 July 2024
- 稿件说明：
移动端阅览
梁婉诗,廖怡茹,付靖涵等.1221例女性基础性激素水平及抗苗勒管激素水平不同年龄段变化特征——女子“以七为期”的生殖衰老规律回顾性研究[J].中医杂志,2024,65(13):1369-1374.

LIANG Wanshi,LIAO Yiru,FU Jinghan,et al.Characteristics of Basal Sex Hormone Levels and Anti-müllerian Hormone Levels in 1221 Women of Different Ages：A Retrospective Study on the Law of Women Reproductive Aging in the "Seven-year Period" Theory[J].Journal of Traditional Chinese Medicine,2024,65(13):1369-1374.
梁婉诗,廖怡茹,付靖涵等.1221例女性基础性激素水平及抗苗勒管激素水平不同年龄段变化特征——女子“以七为期”的生殖衰老规律回顾性研究[J].中医杂志,2024,65(13):1369-1374. DOI： 10.13288/j.11-2166/r.2024.13.011.

LIANG Wanshi,LIAO Yiru,FU Jinghan,et al.Characteristics of Basal Sex Hormone Levels and Anti-müllerian Hormone Levels in 1221 Women of Different Ages：A Retrospective Study on the Law of Women Reproductive Aging in the "Seven-year Period" Theory[J].Journal of Traditional Chinese Medicine,2024,65(13):1369-1374. DOI： 10.13288/j.11-2166/r.2024.13.011.

摘要

目的

从基础性激素水平及抗苗勒管激素水平不同年龄段变化特征探析中医理论中女子“以七为期”的生殖衰老规律。

方法

回顾性收集2018年1月至2022年12月于广东省中医院就诊并行基础性激素及抗苗勒管激素水平检测的女性就诊者数据资料，根据不同年龄段分为一七/二七组（21岁以下）、三七组（21~27岁）、四七组（28~34岁）、五七组（35~41岁）、六七组（42~48岁）及七七及以后组（49岁及以上）。收集就诊者年龄、平均月经周期（近3个月），基础性激素［包括卵泡刺激素（FSH）、黄体生成素（LH）、雌二醇（E

）、睾酮（T）］水平及FSH/LH值，抗苗勒管激素（AMH）水平，比较各组数据资料中各指标的变化情况。

结果

共纳入数据资料1221份。各组总体上FSH、LH、FSH/LH值、E

、T、AMH水平及平均月经周期差异均有统计学意义（

＜0.05或

＜0.01）。三七组的AMH出现峰值。与三七组相比，四七组FSH/LH值升高，LH、AMH和T水平下降，月经周期缩短（

＜0.01）。五七组FSH/LH值继续升高，LH、AMH、T水平继续下降，月经周期继续缩短，FSH和E

水平开始升高（

＜0.05或

＜0.01）。与五七组比较，六七组FSH、LH、E

水平均升高，AMH、T水平继续降低（

＜0.05或

＜0.01）。与六七组比较，七七及以后组FSH、LH水平继续升高，AMH、E

水平下降（

＜0.01）。

结论

女子“以七为期”的生殖衰老规律与不同年龄段基础性激素水平及抗苗勒管激素水平变化特征基本相符，其中“三七”阶段生殖能力达到峰值，“四七”阶段开始逐渐走向生殖衰老。

Abstract

Objective

To explore the law of women reproductive aging based on theory of "seven-year period" in traditional Chinese medicine（TCM） through analyzing the characteristics of basic sex hormone levels and anti-müllerian hormone levels in women of different ages.

Methods

The data of female who visited Guangdong Provincial Hospital of Traditional Chinese Medicine from January 2018 to December 2022 and accepted basic hormone and anti-müllerian hormone determination were collected retrospectively. According to the age of subjects， they were divided into the "1

2 seven" group （under 21 years old）， "3 seven" group （21

27 years old）， "4 seven" group （28

34 years old）， "5 seven" group （35

41 years old）， "6 seven" group （42

48 years old） and "7 seven" and older group （49 years old and above）. The age， a

verage menstrual cycle in the past 3 months， basic hormone levels including follicle stimulating hormone （FSH）， luteinizing hormone （LH）， estradiol （E

）， testosterone （T） and FSH/LH value， and anti-müllerian hormone （AMH） levels were collected and compared.

Results

A total of 1221 cases were included. The differences in FSH， LH， FSH/LH values， E

， T， AMH levels and average menstrual cycle among the groups were statistically significant （

＜0.05 or

＜0.01）. AMH peaked in the "3 seven" group. Compared to those in the "3 seven" group， the FSH/LH value in the "4 seven" group increased， while the LH， AMH and T levels decreased， and the menstrual cycle was shortened （

＜0.01）. The FSH/LH， LH， AMH， T and menstrual cycle in the "5 seven" group were consistent with the changing trend of those in the "4 seven" group， while the FSH and E

levels in the "5 seven" group were significantly higher （

＜0.05 or

＜0.01）. Compared to those in the "5 seven" group， the FSH， LH and E

levels of the "6 seven" group increased， and the AMH and T levels continued to decrease （

＜0.05 or

＜0.01）. Compared to those in the "6 seven" group， the FSH and LH levels of the "7 seven" and older group continued to increase， and the AMH and E

levels decreased （

＜0.01）.

Conclusion

The law of women reproductive aging in the "seven-year period" theory is basically consistent with the characteristics of basic sex hormone levels and anti-müllerian hormone levels in women of different ages. The reproductive capacity reaches its peak in the "three-seven-year period" and gradually moves towards reproductive aging in the "four-seven-year period".

关键词

Keywords

references

KUANG X ， TANG Y ， XU H ， et al . The evaluation of ovarian function recovery following treatment of primary ovarian insufficiency： a systematic review ［J］. Front Endocrinol （Lausanne）， 2022 ， 13 ： 855992 . doi： 10.3389/fendo. 2022. 855992 http://dx.doi.org/10.3389/fendo.2022.855992 .

FADDY MJ . Follicle dynamics during ovarian ageing ［J］. Mol Cell Endocrinol ， 2000 ， 163 （ 1/2 ）： 43 - 48 .

蒋励，陈耀龙，罗旭飞，等 . 中国高龄不孕女性辅助生殖临床实践指南［J］. 中国循证医学杂志， 2019 ， 19 （ 3 ）： 253 - 270 .

中华医学会妇产科学分会绝经学组 . 中国绝经管理与绝经激素治疗指南2023版［J］. 中华妇产科杂志， 2023 ， 58 （ 1 ）： 4 - 21 .

NEELY EK ， HINTZ RL ， WILSON DM ， et al . Normal ranges for immunochemiluminometric gonadotropin assays ［J］. J Pediatr ， 1995 ， 127 （ 1 ）： 40 - 46 .

ARAT Ö ， DEVECI D ， ÖZKAN ZS ， et al . What is the effect of the early follicular phase FSH/LH ratio on the number of mature oocytes and embryo development？［J］. Turk J Med Sci ， 2020 ， 50 （ 2 ）： 420 - 425 .

马小玲，张炜 . 促性腺激素释放激素类似物在妇科疾病治疗中的应用［J］. 上海医药， 2012 ， 33 （ 21 ）： 6 - 8 .

CHEUNG CC ， LUSTIG RH . Pituitary development and physiology ［J］. Pituitary ， 2007 ， 10 （ 4 ）： 335 - 350 .

PADMANABHAN V ， MANIKKAM M ， RECABARREN S ， et al . Prenatal testosterone excess programs reproductive and metabolic dysfunction in the female ［J］. Mol Cell Endocrinol ， 2006 ， 246 （ 1/2 ）： 165 - 174 .

DRUCKMANN R . Progestins and their effects on the breast ［J］. Maturitas ， 2003 ， 46 （ 1 ）： S59 - S69 .

MOOLHUIJSEN LME ， VISSER JA . Anti-müllerian hormone and ovarian reserve： update on assessing ovarian function ［J］. J Clin Endocrinol Metab ， 2020 ， 105 （ 11 ）： 3361 - 3373 .

YOUNIS JS ， ISKANDER R ， FAUSER BCJM ， et al . Does an association exist between menstrual cycle length within the normal range and ovarian reserve biomarkers during the reproductive years？ A systematic review and meta-analysis ［J］. Hum Reprod Update ， 2020 ， 26 （ 6 ）： 904 - 928 .

WISE PM ， DUEKER E ， WUTTKE W . Age-related alte-rations in pulsatile luteinizing hormone release： effects of long-term ovariectomy， repeated pregnancies and naloxone ［J］. Biol Reprod ， 1988 ， 39 （ 5 ）： 1060 - 1066 .

AHMED TA ， AHMED SM ， EL-GAMMAL Z ， et al . Oocyte aging： the role of cellular and environmental factors and impact on female fertility ［J］. Adv Exp Med Biol ， 2020 ， 1247 ： 109 - 123 . doi： 10.1007/5584_2019_456 http://dx.doi.org/10.1007/5584_2019_456 .

KLIGMAN I ， ROSENWAKS Z . Differentiating clinical profiles： predicting good responders， poor responders， and hyperresponders ［J］. Fertil Steril ， 2001 ， 76 （ 6 ）： 1185 - 1190 .

YOUNIS JS ， JADAON J ， IZHAKI I ， et al . A simple multivariate score could predict ovarian reserve， as well as pregnancy rate， in infertile women ［J］. Fertil Steril ， 2010 ， 94 （ 2 ）： 655 - 661 .

LUINE VN . Estradiol and cognitive function： past， pre-sent and future ［J］. Horm Behav ， 2014 ， 66 （ 4 ）： 602 - 618 .

LICCIARDI FL ， LIU HC ， ROSENWAKS Z . Day 3 estradiol serum concentrations as prognosticators of ovarian stimulation response and pregnancy outcome in patients undergoing in vitro fertilization ［J］. Fertil Steril ， 1995 ， 64 （ 5 ）： 991 - 994 .

廖旖欣，全松 . 卵巢储备功能的评估与控制性卵巢刺激方案的选择［J］. 实用妇产科杂志， 2019 ， 35 （ 5 ）： 324 - 326 .

SHRIKHANDE L ， SHRIKHANDE B ， SHRIKHANDE A . AMH and Its Clinical Implications ［J］. J Obstet Gynaecol India ， 2020 ， 70 （ 5 ）： 337 - 341 .

李嘉，马文，童秋瑜，等 . 卵巢储备功能评估的研究进展［J］. 安徽医学， 2018 ， 39 （ 1 ）： 116 - 119 .

陈蓉，罗敏 . 早发性卵巢功能不全的相关术语［J］. 中国实用妇科与产科杂志， 2023 ， 39 （ 9 ）： 869 - 871 .

HAGEN CP ， AKSGLAEDE L ， SØRENSEN K ， et al . Serum levels of anti-müllerian hormone as a marker of ovarian function in 926 healthy females from birth to adulthood and in 172 turner syndrome patients ［J］. J Clin Endocrinol Metab ， 2010 ， 95 （ 11 ）： 5003 - 5010 .

MUMUSOGLU S ， YILDIZ BO . Metabolic syndrome during menopause ［J］. Curr Vasc Pharmacol ， 2019 ， 17 （ 6 ）： 595 - 603 .

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of Traditional Chinese Medicine Therapy on Immune Reconstitution in Children after Hematopoietic Stem Cell Transplantation：A Retrospective Real-World Study

Real-World Effects Evaluation of the Strengthening Spleen，Tonifying the Kidney，and Detoxifying Method in the Treatment of Advanced Colorectal Cancer：A Multi-Center，Retrospective Cohort Study

Clinical Efficacy of Janus Kinase Inhibitors in Combination with Chinese Herbal Medicine for Rheumatoid Arthritis：A Retrospective Study and A Meta-analysis

Effectiveness of Traditional Chinese Medicine Chronic Disease Management Programme after Colorectal Polyp Surgery：A Retrospective Cohort Study

Analysis on the Difference of Median Survival Time of Advanced Pancreatic Cancer Patients with Different Traditional Chinese Medicine Syndromes and Intervention Times of Chinese Herbal Medicine：A Retrospective Study

Related Author

HUANG Baoyi

YI Lichen

LI Yanwei

HUANG Ke

XU Hua

LI Rui

XU Yuying

WU Beibei

Related Institution

Children's Medical Center，SunYat-sen Memorial Hospital，SunYat-sen University

Guangzhou University of Chinese Medicine

Guangdong Clinical Research Academy of Chinese Medicine

The First Affiliated Hospital of Guangzhou University of Chinese Medicine

Peking University Cancer Hospital

Address：No.16, Nanxiao street, Dongzhimen, Dongcheng District, Beijing Postal code：100700
Tel：010-64035632 Email：jtcmcn@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010102007558号
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰