Exploring the Application of Phenomics in Traditional Chinese Medicine Syndromes Studies Based on the Relationship between Phenotypes and Syndromes

HU Jinhao; SUN Guiyan; YANG Yufeng; SHI Yan

doi:10.13288/j.11-2166/r.2024.14.016

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Exploring the Application of Phenomics in Traditional Chinese Medicine Syndromes Studies Based on the Relationship between Phenotypes and Syndromes

更新时间：2024-07-19

- Exploring the Application of Phenomics in Traditional Chinese Medicine Syndromes Studies Based on the Relationship between Phenotypes and Syndromes
- Journal of Traditional Chinese Medicine Vol. 65, Issue 14, Pages: 1514-1517(2024)
- 作者机构：
  
  辽宁中医药大学，辽宁省沈阳市皇姑区崇山东路79号，100847
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2024.14.016
  CLC：
- Received：24 February 2024，
  
  Revised：2024-04-18，
  
  Published：17 July 2024
- 稿件说明：
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胡锦浩,孙贵炎,杨宇峰等.基于表型与证候的关系探讨表型组学技术在中医证候研究中的应用[J].中医杂志,2024,65(14):1514-1517.

HU Jinhao,SUN Guiyan,YANG Yufeng,et al.Exploring the Application of Phenomics in Traditional Chinese Medicine Syndromes Studies Based on the Relationship between Phenotypes and Syndromes[J].Journal of Traditional Chinese Medicine,2024,65(14):1514-1517.
胡锦浩,孙贵炎,杨宇峰等.基于表型与证候的关系探讨表型组学技术在中医证候研究中的应用[J].中医杂志,2024,65(14):1514-1517. DOI： 10.13288/j.11-2166/r.2024.14.016.

HU Jinhao,SUN Guiyan,YANG Yufeng,et al.Exploring the Application of Phenomics in Traditional Chinese Medicine Syndromes Studies Based on the Relationship between Phenotypes and Syndromes[J].Journal of Traditional Chinese Medicine,2024,65(14):1514-1517. DOI： 10.13288/j.11-2166/r.2024.14.016.

摘要

通过分析表型与中医证候的概念内涵，阐释中医证候、表型与疾病的关系。认为表型与中医证候具有一定的相似性，二者均通过外在表现阐述人体的生理与病理机制，兼具阶段性与整体性的时空特点，同时注重先天与后天的联系。总结目前表型组学技术在中医证候研究中的应用现状，认为借助表型组学技术对中医证候内在生物学机制的研究已取得一定的成果，但仍存在中医证候与表型的匹配性探索困难、现有疾病表型体系尚待补充、对“证”本质的认识尚未达成统一等问题。提出今后可通过大型临床数据库广泛收集与特定疾病具有密切关系的各种中医证候与表型信息，先通过表型组学技术将单一证候与相应表型进行初步对应与鉴别，再进一步对复合证候进行更为精准的表型检测，最后借助人工智能技术实现中医证候诊断的标准化与智能化。从表型的角度阐述中医证候的现代科学内涵，可为中医证型的判定及证型现代生物标志物的明确提供科学依据，为中医证候的现代化研究提供思路。

Abstract

By analysing the conceptual connotations of phenotype and traditional Chinese medicine （TCM） symptoms， the relationship between TCM symptoms， phenotypes and diseases is explained. It is believed that phenotypes and TCM syndromes have certain similarities， both of which elaborate the physiological and pathological mechanisms of the human body through external manifestations， and have the temporal and spatial characteristics of both phases and wholeness， as well as focusing on the connection between the innate and the acquired. Summarising the current status of the application of phenomics technology in the studies of TCM syndromes， it is concluded that the study of the intrinsic biological mechanisms of TCM syndromes with the help of phenomics technology has achieved certain results， but there are still problems such as difficulties in matching between traditional Chinese medicine syndromes and phenotypes， the incompleteness of the existing disease phenotype system， and the inconsistency of the understanding about "syndromes". It is proposed that in the future， large-scale clinical databases could be used to collect a wide range of TCM syndromes and phenotypes that are closely related to specific diseases. The phenomics technology could make preliminary correspondence and identification between a single syndrome and the corresponding phenotype， and then further carry out a more accurate phenotypic detection of the composite syndromes， and finally realise the standardization and intelligence of the diagnosis of TCM syndromes with the help of the artificial intelligence technology. By elaborating the modern scientific connotation of TCM syndromes from the perspective of phenotypes， we can provide scientific basis for the determination of TCM syndromes and the clarification of modern biomarkers of syndromes， as well as ideas for the modernisation research of TCM syndromes.

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