Clinical Effectiveness of Bee Acupuncture Therapy in the Treatment of Knee Osteoarthritis on Symptoms Improvement and IL-6： A Randomized Controlled Trial

XU Ming; HUANG Ziling; WANG Ziyi; HOU Xunrui; ZHAO Peiling; MEI Jingyan

doi:10.13288/j.11-2166/r.2024.18.010

您当前的位置：

首页 >

文章列表页 >

Clinical Effectiveness of Bee Acupuncture Therapy in the Treatment of Knee Osteoarthritis on Symptoms Improvement and IL-6： A Randomized Controlled Trial

更新时间：2024-09-11

- Clinical Effectiveness of Bee Acupuncture Therapy in the Treatment of Knee Osteoarthritis on Symptoms Improvement and IL-6： A Randomized Controlled Trial
- Journal of Traditional Chinese Medicine Vol. 65, Issue 18, Pages: 1903-1908(2024)
- 作者机构：
  
  1.贵州医科大学附属医院，贵州省贵阳市云岩区贵医街28号，550000
  2.贵州大学医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2024.18.010
  CLC：
- Received：22 April 2024，
  
  Revised：2024-07-15，
  
  Published：17 September 2024
- 稿件说明：
移动端阅览
徐明,黄子玲,王紫衣等.蜂针疗法对膝关节骨性关节炎患者症状、体征及关节液白细胞介素6水平影响的随机对照试验[J].中医杂志,2024,65(18):1903-1908.

XU Ming,HUANG Ziling,WANG Ziyi,et al.Clinical Effectiveness of Bee Acupuncture Therapy in the Treatment of Knee Osteoarthritis on Symptoms Improvement and IL-6： A Randomized Controlled Trial[J].Journal of Traditional Chinese Medicine,2024,65(18):1903-1908.
徐明,黄子玲,王紫衣等.蜂针疗法对膝关节骨性关节炎患者症状、体征及关节液白细胞介素6水平影响的随机对照试验[J].中医杂志,2024,65(18):1903-1908. DOI： 10.13288/j.11-2166/r.2024.18.010.

XU Ming,HUANG Ziling,WANG Ziyi,et al.Clinical Effectiveness of Bee Acupuncture Therapy in the Treatment of Knee Osteoarthritis on Symptoms Improvement and IL-6： A Randomized Controlled Trial[J].Journal of Traditional Chinese Medicine,2024,65(18):1903-1908. DOI： 10.13288/j.11-2166/r.2024.18.010.

摘要

目的

观察蜂针疗法对膝关节骨性关节炎患者临床症状、体征及关节液中炎性因子白细胞介素6（IL-6）水平的影响。

方法

采用随机数字表法将94例膝关节骨性关节炎患者分配至治疗组及对照组，两组各47例。两组均给予每日晨起1片（60 mg）依托考昔片口服，持续2周，对照组联合患侧微针浅刺针刺疗法，每天1次，连续5次后暂停2天，再继续5次，为1个疗程；治疗组联合蜂针疗法治疗，隔2天行1次患侧蜂针治疗，每周2次，4次为1个疗程。两组均进行1个疗程（2周）的治疗。观察两组患者在治疗前、治疗后1周、治疗后2周及12周随访时临床症状、体征的变化，比较两组患者膝关节骨性关节炎严重度指数（Lequesne指数）评分、美国特种外科医院膝关节评分（HSS评分）、视觉模拟量表评分（VAS评分）和膝关节液IL-6水平的差异。

结果

两组均无患者脱落。与治疗前比较，两组治疗后各时间点Lequesne指数评分、VAS评分均降低，HSS评分均升高（

＜0.05）。两组治疗后同时间比较，治疗组Lequesne指数评分、VAS评分均低于对照组，HSS评分均高于对照组（

＜0.05）。治疗组12周随访时膝关节液IL-6水平较治疗前降低（

＜0.05），但各时间点组间比较差异无统计学意义（

＞0.05）。

结论

蜂针疗法治疗膝关节骨性关节炎可明显改善临床症状、体征，但对膝关节液IL-6的水平变化无明显影响。

Abstract

Objective

To observe the effect of bee acupuncture therapy on clinical symptoms and signs， as well as the level of inflammatory cytokine interleukin-6 （IL-6） in synovial fluid of patients with knee osteoarthritis.

Methods

The 94 patients with knee osteoarthritis were divided into the control group and the trial group by the random number table method， with 47 cases in each group. Both groups were given one tablet （60 mg） of etoricoxib orally every morning for 2 weeks. The control group also received microneedle shallow acupuncture therapy， once a day for 5 consecutive times followed 2-day pause， and continued 5 consecutive times， as a course of treatment； the trial group was treated with bee acupuncture therapy once every 2 days， 2 times a week， and 4 times as a course of treatment. Both groups have a course of treatment for 2 weeks. The changes in clinical symptoms and signs of patients in the two groups were observed and evaluated before treatment， after 1- and 2-week treatment， and 12-week follow-up and the differences in Lequesne index scores， HSS scores， Visual Analogue Scale （VAS） scores and IL-6 levels in knee synovial fluid between the two groups of patients were also compared.

Results

No patients lost to follow up in either group. The Lequesne index scores and VAS scores were lower， and the HSS scores were higher in both groups at all time points after treatment compared with those before treatment （

＜0.05）. Compared at the same time after treatment， the Lequesne index scores and VAS scores of the trial group were lower than those of the control group， and the HSS scores were higher than those of the control group （

＜0.05）. IL-6 in synovial fluid was lower in the trial group at the 12-week follow-up than before treatment （

＜0.05）， but there was no significant difference between two groups at each time point（

＞0.05）.

Conclusion

Bee acupuncture therapy for knee osteoarthritis can significantly improve clinical signs and symptoms， but has no significant effect on the level of IL-6 in knee synovial fluid.

关键词

Keywords

references

REN Y ， HU J ， TAN J ， et al . Incidence and risk factors of symptomatic knee osteoarthritis among the Chinese population： analysis from a nationwide longitudinal study ［J］. BMC Public Health ， 2020 ， 20 （ 1 ）： 1491 .

PEREIRA D ， RAMOS E ， BRANCO J . Osteoarthritis ［J］. Acta Med Port ， 2015 ， 28 （ 1 ）： 99 - 106 .

朱治龙，黄国鑫，艾金伟，等 . 全球膝关节骨性关节炎发病率和患病率分析与趋势预测［J］. 湖北医药学院学报， 2023 ， 42 （ 6 ）： 647 - 654 .

HUNTER DJ ， BIERMA-ZEINSTRA S . Osteoarthritis ［J］. Lancet ， 2019 ， 393 （ 10182 ）： 1745 - 1759 .

TATEIWA D ， YOSHIKAWA H ， KAITO T . Cartilage and bone destruction in arthritis： Pathogenesis and treatment strategy： A literature review ［J］. Cells ， 2019 ， 8 （ 8 ）： 818 .

丁小芬，周友龙，田明月，等 . Wnt/β-catenin信号通路与膝关节骨性关节炎软骨代谢［J］. 中国老年学杂志， 2022 ， 42 （ 23 ）： 5917 - 5921 .

SHARMA L . Osteoarthritis of the knee ［J］. N Engl J Med ， 2021 ， 384 （ 1 ）： 51 - 59 .

丛莘，金庆文，谢芳 . 膝关节骨性关节炎针灸治疗现状和存在问题综述［J］. 吉林中医药， 2005 ， 25 （ 7 ）： 57 - 58 .

CHERNIACK EP ， GOVORUSHKO S . To bee or not to bee： The potential efficacy and safety of bee venom acupuncture in humans ［J］. Toxicon ， 2018 ， 154 ： 74 - 78 . doi： 10.1016/j.toxicon.2018.09.013 http://dx.doi.org/10.1016/j.toxicon.2018.09.013 .

HOCHBERG MC ， ALTMAN RD ， BRANDT KD ， et al . Guidelines for the medical management of osteoarthritis. Part Ⅱ. Osteoarthritis of the knee. American College of Rheumatology ［J］. Arthritis and Rheumatism ， 1995 ， 38 （ 11 ）： 1541 - 1546 .

李康，贺佳 . 医学统计学［M］. 6版 . 北京：人民卫生出版社， 2013 ： 158 - 160 .

高树中，冀来喜 . 针灸治疗学［M］. 9版 . 北京：中国中医药出版社， 2012 ： 35 - 36 .

李万瑶 . 蜂针疗法［M］. 2版 . 北京：人民卫生出版社， 2009 .

LEQUESNE MG . The algofunctional indices for hip and knee osteoarthritis ［J］. J Rheumatol ， 1997 ， 24 （ 4 ）： 779 - 781 .

INSALL JN ， RANAWAT CS ， AGLIETTI P ， et al . A comparison of four models of total knee-replacement prostheses ［J］. J Bone Joint Surg Am ， 1976 ， 58 （ 6 ）： 754 - 765 .

MCCORMACK HM ， HORNE DJ ， SHEATHER S . Clinical applications of visual analogue scales： a critical review ［J］. Psychol Med ， 1988 ， 18 （ 4 ）： 1007 - 1019 .

李丽，李宁，吴滨 . 针灸治疗膝关节骨性关节炎的文献计量学分析［J］. 中国针灸， 2007 ， 27 （ 11 ）： 862 - 864 .

周新宇，田元祥 . 国际蜂针疗法研究的知识图谱可视化分析［J］. 世界科学技术-中医药现代化， 2020 ， 22 （ 8 ）： 2764 - 2771 .

林璐璐，孙宁，王雪蕊，等 . 膝关节骨性关节炎常用评价量表的比较与分析［J］. 中国疼痛医学杂志， 2018 ， 24 （ 2 ）： 135 - 139 .

应建伟，裘伟国，刘其顺，等 . 针灸治疗膝骨关节炎对患者疾病改善及预防复发观察［J］. 上海针灸杂志， 2018 ， 37 （ 10 ）： 1202 - 1206 .

刘金芝，杨顺益，冯淑兰 . 蜂针疗法述评［J］. 中国民间疗法， 2000 ， 8 （ 12 ）： 23 - 24 .

朱宝玉，王奇缘，吴蓓，等 . IL-6、VEGF在骨关节炎患者膝关节滑膜和滑液中的表达及其意义［J］. 中国老年学杂志， 2012 ， 32 （ 2 ）： 273 - 275 .

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Methodological Issues in the Design，Evaluation，and Reporting of Randomized Controlled Trials with "Pattern Dominating Disease"

Effect of Electroacupuncture on Metabolism-Inflammation Network in Patients with Simple Obesity：A Randomized Controlled Trial

Acupuncture Treatment for Severe Bell's Palsy and Its Impact on Serum GDNF and NGF：A Randomized Controlled Trial

Effect of Heat-sensitive Moxibustion on Quality of Life and Immune Function in Non-Small Cell Lung Cancer Patients with Qi Deficiency and Phlegm Stasis Syndrome Undergoing Chemotherapy：A Randomized Controlled Trial

Current Status and Strategic Recommendations for Randomized Controlled Trials on Functional Dyspepsia-Irritable Bowel Syndrome Comorbidity：from a Real-World Research Perspective

Related Author

WANG Lu

WANG Jiajia

ZHANG Yingying

LUO Xufei

CHEN Yaolong

LI Jiansheng

SHU Qi

PENG Qiumei

Related Institution

Lung Disease Diagnosis and Treatment，The First Affiliated Hospital of Henan University of Chinese Medicine

Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province Education Ministry of P.R.China/Henan Key Laboratory of Chinese Medicine for Respiratory Diseases，Henan University of Chinese Medicine

School of Chinese Medicine，Hong Kong Baptist University

Research Unit of Evidence-Based Evaluation and Guidelines，Chinese Academy of Medical Sciences，School of Basic Medical Sciences，Lanzhou University

Key Laboratory of Evidence Based Medicine of Gansu Province

Address：No.16, Nanxiao street, Dongzhimen, Dongcheng District, Beijing Postal code：100700
Tel：010-64035632 Email：jtcmcn@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010102007558号
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰