Discussion on the Treatment of Acute Exacerbation of Rheumatoid Arthritis-Associated Interstitial Lung Disease Based on ZHANG Jingyue's View of <italic style="font-style: italic">Yin</italic>-<italic style="font-style: italic">Yang</italic> Holism

LIANG Yanxia; LI Guangsen; WANG Wenwen; LIU Fenggu; SU Wenwen; ZHAO Huiying; XING Hongfei; FAN Maorong

doi:10.13288/j.11-2166/r.2024.18.016

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Discussion on the Treatment of Acute Exacerbation of Rheumatoid Arthritis-Associated Interstitial Lung Disease Based on ZHANG Jingyue's View of Yin-Yang Holism

更新时间：2024-09-11

- Discussion on the Treatment of Acute Exacerbation of Rheumatoid Arthritis-Associated Interstitial Lung Disease Based on ZHANG Jingyue's View of Yin-Yang Holism
- Journal of Traditional Chinese Medicine Vol. 65, Issue 18, Pages: 1943-1947(2024)
- 作者机构：
  
  1.中国中医科学院西苑医院，北京市海淀区西苑操场1号，100091
  2.北京中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2024.18.016
  CLC：
- Received：10 April 2024，
  
  Revised：2024-05-18，
  
  Published：17 September 2024
- 稿件说明：
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梁艳霞,李广森,王雯雯等.基于张景岳阴阳一体观探讨类风湿关节炎相关间质性肺病急性加重的治疗[J].中医杂志,2024,65(18):1943-1947.

LIANG Yanxia,LI Guangsen,WANG Wenwen,et al.Discussion on the Treatment of Acute Exacerbation of Rheumatoid Arthritis-Associated Interstitial Lung Disease Based on ZHANG Jingyue's View of Yin-Yang Holism[J].Journal of Traditional Chinese Medicine,2024,65(18):1943-1947.
梁艳霞,李广森,王雯雯等.基于张景岳阴阳一体观探讨类风湿关节炎相关间质性肺病急性加重的治疗[J].中医杂志,2024,65(18):1943-1947. DOI： 10.13288/j.11-2166/r.2024.18.016.

LIANG Yanxia,LI Guangsen,WANG Wenwen,et al.Discussion on the Treatment of Acute Exacerbation of Rheumatoid Arthritis-Associated Interstitial Lung Disease Based on ZHANG Jingyue's View of Yin-Yang Holism[J].Journal of Traditional Chinese Medicine,2024,65(18):1943-1947. DOI： 10.13288/j.11-2166/r.2024.18.016.

摘要

基于张景岳阴阳一体观，探讨类风湿关节炎相关间质性肺病（RA-ILD）急性加重的病因病机及治法。认为RA-ILD急性加重的基础为真阴不足、阴不制阳；外邪侵袭是RA-ILD急性加重的常见诱因。治疗时首当潜降相火，方用引火汤加减；相火已潜则专注于培补阴阳，若为真阴亏虚为主，可选用左归丸加减，若真阳亏虚亦明显，可选用右归丸加减。阴阳平衡，则病情得解。

Abstract

This article is based on ZHANG Jingyue's theory of

yin

yang

holism to explore the etiology， pathogenesis， and treatment of acute exacerbation of rheumatoid arthritis-associated interstitial lung disease （RA-ILD）. It is believed that the foundation of acute exacerbation of RA-ILD lies in real

yin

insufficiency and

yin

fail to control

yang

； external pathogen attacking is a common cause of acute exacerbation of RA-ILD. For treatment， it is important to first suppress ministerial fire by prescribing modified

Yinhuo Decoction

（引火汤）； if ministerial fire submerged， focus should be on nourishing both

yin

and

yang

； if real

yin

deficiency is the main issue， modified

Zuogui Pill

（左归丸） should be used； if real

yang

deficiency is prominent as well， modified

Yougui Pill

（右归丸） can be chosen. When

yin

and

yang

balanced， the disease could be solved.

关键词

Keywords

references

AKIYAMA M ， KANEKO Y . Pathogenesis， clinical features， and treatment strategy for rheumatoid arthritis-associated interstitial lung disease ［J］. Autoimmun Rev ， 2022 ， 21 （ 5 ）： 103056 .

KADURA S ， RAGHU G . Rheumatoid arthritis-interstitial lung disease： manifestations and current concepts in pathogenesis and management ［J］. Eur Respir Rev ， 2021 ， 30 （ 160 ）： 210011 - 210028 .

LI L ， LIU R ， ZHANG Y ， et al . A retrospective study on the predictive implications of clinical characteristics and therapeutic management in patients with rheumatoid arthritis-associated interstitial lung disease ［J］. Clin Rheumatol ， 2020 ， 39 （ 5 ）： 1457 - 1470 .

YOO H ， HINO T ， HWANG J ， et al . Connective tissue disease-related interstitial lung disease （CTD-ILD） and interstitial lung abnormality （ILA）： Evolving concept of CT findings， pathology and management ［J］. Eur J Radiol Open ， 2022 ， 9 （ 7 ）： 100419 - 100430 .

RAIMUNDO K ， SOLOMON JJ ， OLSON AL ， et al . Rheumatoid arthritis-interstitial lung disease in the United States： prevalence， incidence， and healthcare costs and mortality ［J］. J Rheumatol ， 2019 ， 46 （ 4 ）： 360 - 369 .

KALYONCU U ， BILGIN E ， ERDEN A ， et al . Efficacy and safety of tofacitinib in rheumatoid arthritis-associated interstitial lung disease： TReasure real-life data ［J］. Clin Exp Rheumatol ， 2022 ， 40 （ 11 ）： 2071 - 2077 .

CASSONE G ， MANFREDI A ， VACCHI C ， et al . Treatment of rheumatoid arthritis-associated interstitial lung disease： lights and shadows ［J］. J Clin Med ， 2020 ， 9 （ 4 ）： 1082 - 1116 .

张瑶，梅俊，徐凤芹，等 . 运用引火汤治疗不寐的辨治思路探讨［J］. 现代中医临床， 2023 ， 30 （ 2 ）： 109 - 112 .

寿越敏，沈钦荣 . 沈钦荣运用张景岳“真阴为本”思想治疗筋骨病经验［J］. 浙江中医杂志， 2019 ， 54 （ 6 ）： 396 - 397 .

何丽娟，初杰，宋囡，等 . 从左归丸与右归丸探究张景岳之阴阳观［J］. 中医杂志， 2014 ， 55 （ 1 ）： 83 - 85 .

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Related Institution

Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine

Nanjing University of Chinese Medicine

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The First Affiliated Hospital of Anhui University of Chinese Medicine/Anhui Provincial Key Laboratory for Applied Basic and Clinical Translational Research of Traditional Chinese Medicine Rheumatology

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Discussion on the Treatment of Acute Exacerbation of Rheumatoid Arthritis-Associated Interstitial Lung Disease Based on ZHANG Jingyue's View of Yin-Yang Holism

DOI：10.13288/j.11-2166/r.2024.18.016

摘要

Abstract

关键词

Keywords

references