WANG Haihong,SONG Yu,HE Fan,et al.Correlation between Circulating Tumor Cells and Recurrence-Metastasis of Colorectal Cancer based on the Theory of Latent Pathogens[J].Journal of Traditional Chinese Medicine,2024,65(19):1983-1987.
WANG Haihong,SONG Yu,HE Fan,et al.Correlation between Circulating Tumor Cells and Recurrence-Metastasis of Colorectal Cancer based on the Theory of Latent Pathogens[J].Journal of Traditional Chinese Medicine,2024,65(19):1983-1987.DOI: 10.13288/j.11-2166/r.2024.19.006.
Correlation between Circulating Tumor Cells and Recurrence-Metastasis of Colorectal Cancer based on the Theory of Latent Pathogens
There is a certain correlation and interaction between circulating tumor cells and recurrence-metastasis of colorectal cancer. The circulating tumor cells hidden in the human body can lead to the recurrence and metastasis of colorectal cancer, and the recurrence and metastasis of colorectal cancer can in turn cause a sharp increase in the number of circulating tumor cells, which is consistent with the characteristics of latent pathogens in traditional Chinese medicine leading to diseases. Starting from the theory of latent pathogens, this article summarized the etiology and disease mechanism of recurrence-metastasis of colorectal cancer
as harmed healthy
qi
, latent pathogenic
qi
, prolonged latent pathogens, and triggering healthy
qi
deficiency. This article also proposes four major treatment methods as reinforcing healthy
qi
, assisting
yang
, opening the exterior, and expelling pathogen, in order to provide ideas and methods for the prevention and treatment of recurrence and metastasis of colorectal cancer.
SEYED MQ , BORIS G , CORNELIS V , et al . Disease recurrence after colorectal cancer surgery in the modern era: a population-based study [J]. Int J Colorectal Dis , 2021 , 36 ( 11 ): 2399 - 2410 .
LOWERS LE , ALLAN AL . Circulating tumor cells and implications of the epithelial-to-mesenchymal transition [J]. Adv Clin Chem , 2018 , 83 : 121 - 181 . doi: 10.1016/bs. acc.2017.10.004 http://dx.doi.org/10.1016/bs.acc.2017.10.004 .
MARIO G , ANUM S , HIN CL , et al . Perspective on circulating tumor cell clusters: why it takes a village to metastasize [J]. Cancer Res , 2018 , 78 ( 4 ): 845 - 852 .
JONATHAN WU , KLAUS P . Controversies in clinical cancer dormancy [J]. Pro Natl Acad Sci USA , 2011 , 108 ( 30 ): 12396 - 12400 .
REN GM , ZHENG GZ , DU KL , et al . Prognostic value of dynamic changes of pre- and post-operative tumor markers in colorectal cancer [J]. Clin Transl Oncol , 2024 , 26 ( 8 ): 2047 - 2059 .
DRAHOMIR K , SACHIN N , JANAALETTA T , et al . Circulating tumor cell kinetics and morphology from the liquid biopsy predict disease progression in patients with metastatic colorectal cancer following resection [J]. Cancers (Basel) , 2022 , 14 ( 3 ): 642 .
WU J , LI ZY , ZOU JH , et al . A meta-analysis of the value of circulating tumor cells in monitoring postoperative recurrence and metastasis of colorectal cancer [J]. PLoS One , 2022 , 17 ( 9 ): 0274282 .
GWANG HP , HUN MS , SU BP , et al . Cytotoxic activity of the twigs of Cinnamomum cassia through the suppression of cell proliferation and the induction of apoptosis in human colorectal cancer cells [J]. BMC Complement Altern Med , 2018 , 18 ( 1 ): 28 .
WEI F , NIAN Q , ZHAO MY , et al . Natural products and mitochondrial allies in colorectal cancer therapy [J]. Biomed Pharmacother , 2023 , 167 : 115473 . doi: org/10. 1016/j.biopha.2023.115473 http://dx.doi.org/org/10.1016/j.biopha.2023.115473 .
SHI ZF , SONG TB , WAN Y , et al . A systematic review and meta-analysis of traditional insect Chinese medicines combined chemotherapy for non-surgical hepatocellular carcinoma therapy [J]. Sci Rep , 2017 , 7 ( 1 ): 4355 .
CHEN YJ , CHANG WM , LIU YW , et al . A small-molecule metastasis inhibitor, norcantharidin, downregulates matrix metalloproteinase-9 expression by inhibiting Sp1 transcriptional activity in colorectal cancer cells [J]. Chem Biol Interact , 2009 , 181 ( 3 ): 440 - 446 .
SHOU LM , ZHANG QY , LI WEI , et al . Cantharidin and norcantharidin inhibit the ability of MCF-7 cells to adhere to platelets via protein kinase C pathway-dependent downregulation of α2 integrin [J]. Oncol Rep , 2013 , 30 ( 3 ): 1059 - 1066 .
Treatment of Postoperative Recurrence and Metastasis of Gastric Cancer Based on the Theory of "Controlling Channels and Collaterals"
Ideas for Prevention and Treatment of Postoperative Recurrence and Metastasis of Gastric Cancer Based on the Theory of “Chuan-she”(传舍) and “Yang Deficiency and Toxic Knot”
Immune-Inflammatory Mechanisms and Traditional Chinese Medicine Intervention Strategies of Colorectal Cancer Cachexia Based on the "Reinforcing Healthy Qi and Dispelling Pathogen" Theory
Prevention and Treatment of the Relapse of Ulcerative Colitis Based on the Theory of Damp-Heat Latent Pathogen
Evaluation of Pulmonary Air-Blood Barrier Damage in Ulcerative Colitis Inflammatory Cancer Transformation Model Mice:Based on the "Lung-Intestine Correlation" Theory
Related Author
KUANG Ziyu
WANG Jiaxi
LI Jie
CAO Luchang
XIE Zhenming
WU Wenyu
HUANG Wenqi
SHUI Huili
Related Institution
Beijing University of Chinese Medicine
Guang 'anmen Hospital,China Academy of Chinese Medical Sciences
The Affiliated Hospital of Zunyi Medical University
Tumor Inheritance and Technological Innovation Talent Base of Traditional Chinese Medicine in Guizhou Province
Guizhou University of Traditional Chinese Medicine