Pathogenesis of Refractory Rheumatoid Arthritis with Healthy <italic style="font-style: italic">Qi</italic> Deficiency and Toxins Accumulation

LIU Wei; KA Yuxiu; CHEN Shujuan

doi:10.13288/j.11-2166/r.2024.22.014

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Pathogenesis of Refractory Rheumatoid Arthritis with Healthy Qi Deficiency and Toxins Accumulation

更新时间：2024-11-12

- Pathogenesis of Refractory Rheumatoid Arthritis with Healthy Qi Deficiency and Toxins Accumulation
- Journal of Traditional Chinese Medicine Vol. 65, Issue 22, Pages: 2368-2372(2024)
- 作者机构：
  
  1.天津中医药大学第一附属医院，天津市西青区昌凌路88号，300193
  2.国家中医针灸临床医学研究中心
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2024.22.014
  CLC：
- Received：24 October 2023，
  
  Revised：2024-08-08，
  
  Published：17 November 2024
- 稿件说明：
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刘维,卡玉秀,陈婌娟.难治性类风湿关节炎正虚毒蕴病机论[J].中医杂志,2024,65(22):2368-2372.

LIU Wei,KA Yuxiu,CHEN Shujuan.Pathogenesis of Refractory Rheumatoid Arthritis with Healthy Qi Deficiency and Toxins Accumulation[J].Journal of Traditional Chinese Medicine,2024,65(22):2368-2372.
刘维,卡玉秀,陈婌娟.难治性类风湿关节炎正虚毒蕴病机论[J].中医杂志,2024,65(22):2368-2372. DOI： 10.13288/j.11-2166/r.2024.22.014.

LIU Wei,KA Yuxiu,CHEN Shujuan.Pathogenesis of Refractory Rheumatoid Arthritis with Healthy Qi Deficiency and Toxins Accumulation[J].Journal of Traditional Chinese Medicine,2024,65(22):2368-2372. DOI： 10.13288/j.11-2166/r.2024.22.014.

摘要

难治性类风湿关节炎属中医学“顽痹”“尫痹”等范畴，认为“毒邪”是其重要致病因素，“正虚毒蕴”为核心病机。毒邪可分为伏毒和内毒，其中伏毒包括先天伏毒和后天外感及药毒之伏邪，内毒由机体脏腑功能障碍直接产生，或湿浊痰瘀转化为毒。毒邪可流注经络，迅蚀骨节，戕害五脏，暗耗正气，蕴结盘踞。据此确立“扶正解毒”之治则，强调治疗关键在于益正气之本源，击毒邪之惰归。临证应溯本求源，审因论治，在扶助正气的基础上，运用清热解毒、利湿解毒、祛风解毒、散寒解毒、化痰解毒、散瘀解毒等法，扶正祛邪兼施，以提高临床疗效。

Abstract

Refractory rheumatoid arthritis belongs to the category of "stubborn

（痹）" and "lame

" in traditional Chinese medicine. It is believed that pathogenic toxin is an important pathogenic factor of refractory rheumatoid arthritis， and "healthy

deficiency and toxins accumulation" is its core pathogenesis. Pathogenic toxin can be divided into latent and internal toxin， among which latent toxin includes congenital latent toxin and acquired exogenous and drug-induced latent toxin； and internal toxin is directly produced by the dysfunction of the body's

zang

（脏腑） organs， or is transformed from dampness， turbidity， phlegm and stasis. Pathogenic toxin can flow into the meridians and collaterals， quickly corrode the bones and joints， harm the five

zang

organs， secretly consume the body's healthy

， and accumulate and entrench. Based on this， the treatment principle of "reinforcing healthy

and resolving toxins" has been established， emphasizing that the key is to strengthen the origin of the body's healthy

and to attack the pathogenic toxin from its weakness. In clinical practice， it is suggested to trace the root cause， and treat the disease based on the cause. Besides reinforcing the body's healthy

， the methods such as clearing heat to resolve toxins， draining dampness to resolve toxins， dispell

ing wind to remove toxins， dispersing cold to resolve toxins， dissolving phlegm to resolve toxins， and dispersing stasis to resolve toxins can be supplemented， so as to reinforce the healthy

and dispel pathogens simultaneously and thereby improving the clinical efficacy.

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references

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Related Institution

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine/National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion

Institute of Traditional Chinese Medicine， Xinjiang Medical University

School of Traditional Chinese Medicine，Beijing University of Chinese Medicine

Xiyuan Hospital，China Academy of Chinese Medical Sciences

Guang'anmen Hospital，China Academy of Chinese Medical Sciences

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Pathogenesis of Refractory Rheumatoid Arthritis with Healthy Qi Deficiency and Toxins Accumulation

DOI：10.13288/j.11-2166/r.2024.22.014

摘要

Abstract

关键词

Keywords

references