To summarize Prof. ZHANG Zhiyuan's clinical experience in using large doses of Fuzi （

Aconiti Lateralis Radix Praeparata

）. The effect of Fuzi is based on its acrid and hot propoerties， warming and invigorating

yang qi

and running without guard. The application of large doses of Fuzi can be categorized into raw and processed， with common dosage ranging from 30 g to 60 g of raw Fuzi， and 15 g to 30 g， 30 g to 60 g of processed Fuzi. The quantity-effect relationship of the large dose of Fuzi is summarized as 15 g to 30 g of processed Fuzi could warm wa

ter， warm

yang

and eliminate timidity， as the treatment of asthma with deficiency cold phlegm， edema of

yang

deficiency， and panic and timidity of

yang

deficiency； 30 g to 60 g of processed Fuzi could tonify fire， warm the meridians and collaterals， assist

yang

to dispel cold and relieve pain， as the treatment of coldness in the limbs， abdominal pain， pain in the joints of the limbs， and loose stools due to deficient

yang qi

and exuberant internal

yin

cold； 30 g to 60 g raw Fuzi could restore

yang

to save from collapse， as the treatment of

yang

depletion after profuse sweating and vomiting. At the same time， different dosages of Fuzi were flexibly paired with other medicines， i.e.， 15 g to 30 g of processed Fuzi was paired with Mahuang （

Ephedrae Herba

） and Xixin （

Asari Radix et Rhizoma

） to assist

yang

to dispel coldness， 30 g to 60 g of processed Fuzi was paired with Baizhu （

Atractylodis macrocephalae rhizoma

） or Wuzhuyu （

Euodiae Fructus

） to warm

yang

and dispel dampness， and 30 g to 60 g of raw Fuzi was paired with Shanzhuyu （

Corni Fructus

） to tonify both

yin

and

yang

.