Stage-Based Intervention in Atherosclerosis Using the "Attacking，Supplementing，Dispersing，Dissipating" Method Based on the Accumulation Syndrome Theory

LUAN Yujie; YUAN Chenlu; CHEN Zizhen; LIU Yijun; WEI Yi; HU Yuanhui

doi:10.13288/j.11-2166/r.2025.07.006

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Stage-Based Intervention in Atherosclerosis Using the "Attacking，Supplementing，Dispersing，Dissipating" Method Based on the Accumulation Syndrome Theory

更新时间：2025-03-27

- Stage-Based Intervention in Atherosclerosis Using the "Attacking，Supplementing，Dispersing，Dissipating" Method Based on the Accumulation Syndrome Theory
- Journal of Traditional Chinese Medicine Vol. 66, Issue 7, Pages: 685-689(2025)
- 作者机构：
  
  1.北京中医药大学研究生院，北京市朝阳区北三环东路11号，100029
  2.中国中医科学院广安门医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2025.07.006
  CLC：
- Received：16 October 2024，
  
  Revised：2024-12-29，
  
  Published：02 April 2025
- 稿件说明：
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栾玉洁,袁晨露,陈子真等.基于积证理论运用攻、消、补、散法分期干预动脉粥样硬化的思路[J].中医杂志,2025,66(07):685-689.

LUAN Yujie,YUAN Chenlu,CHEN Zizhen,et al.Stage-Based Intervention in Atherosclerosis Using the "Attacking，Supplementing，Dispersing，Dissipating" Method Based on the Accumulation Syndrome Theory[J].Journal of Traditional Chinese Medicine,2025,66(07):685-689.
栾玉洁,袁晨露,陈子真等.基于积证理论运用攻、消、补、散法分期干预动脉粥样硬化的思路[J].中医杂志,2025,66(07):685-689. DOI： 10.13288/j.11-2166/r.2025.07.006.

LUAN Yujie,YUAN Chenlu,CHEN Zizhen,et al.Stage-Based Intervention in Atherosclerosis Using the "Attacking，Supplementing，Dispersing，Dissipating" Method Based on the Accumulation Syndrome Theory[J].Journal of Traditional Chinese Medicine,2025,66(07):685-689. DOI： 10.13288/j.11-2166/r.2025.07.006.

摘要

动脉粥样硬化（AS）是由脂质沉积、慢性炎症反应及纤维化等多种病理过程共同作用而形成的病变，病程较长，病因复杂。基于中医积证理论，动脉粥样硬化可归属于“积证”范畴，其病机涉及痰、瘀、虚、结四个因素，提出以攻、消、补、散四法分期干预。根据其病理变化分为积未成期、积已成期、积核期、积核腐化期、积核坚化期、积核重度狭窄期六个阶段，根据疾病不同阶段以扶正固本、益肾健脾，消导化浊、祛除痰浊，疏通气机、散结化瘀，攻积逐瘀、泄浊散结为主进行干预，并随症化裁，旨在为中医药防治AS提供思路。

Abstract

Atherosclerosis is a complex pathological condition resulting from lipid deposition， chronic inflammatory responses， and fibrosis， with a prolonged disease course and multifactorial etiology. Based on the traditional Chinese medicine （TCM） theory of accumulation syndrome， atherosclerosis can be classified under this category， with its pathogenesis involving phlegm， blood stasis， deficiency， and accumulation. This paper proposed a stage-based intervention strategy using the four therapeutic principles of "attacking， supplementing， dispersing， dissipating"， and divided into six stages based on the pathological progression， including the stage of accumulation before formation， the sta

ge of accumulation already formed， the stage of nucleus accumulation， the stage of nucleus accumulation decay， the stage of nucleus accumulation consolidation， and the stage of severe stenosis of nucleus. At different stages， the intervention focuses on reinforcing healthy

and consolidating the root， tonifying the kidneys and spleen， dispersing and removing turbidity， removing phlegm stagnation， promoting

circulation， dispersing accumulations and removing stasis， attacking accumulation and expelling stasis， directing the turbid downward and dispersing accumulation， and treatment would be adjusted based on specific symptoms， which provides a theoretical framework for the prevention and treatment of atherosclerosis with TCM.

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references

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